This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. [provided by RefSeq, Sep 2015] See more...

Aliases for ZNF510 Gene

Aliases for ZNF510 Gene

  • Zinc Finger Protein 510 2 3 4 5
  • KIAA0972 2 4
  • ZNF510 5

External Ids for ZNF510 Gene

Previous GeneCards Identifiers for ZNF510 Gene

  • GC09M094897
  • GC09M096597
  • GC09M098557
  • GC09M099518
  • GC09M069128

Summaries for ZNF510 Gene

Entrez Gene Summary for ZNF510 Gene

  • This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. [provided by RefSeq, Sep 2015]

GeneCards Summary for ZNF510 Gene

ZNF510 (Zinc Finger Protein 510) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for ZNF510 Gene

Additional gene information for ZNF510 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF510 Gene

Genomics for ZNF510 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF510 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF510 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF510

Top Transcription factor binding sites by QIAGEN in the ZNF510 gene promoter:
  • AREB6
  • CREB
  • deltaCREB
  • En-1
  • FAC1
  • FOXO1
  • FOXO1a
  • FOXO4

Genomic Locations for ZNF510 Gene

Genomic Locations for ZNF510 Gene
chr9:96,754,549-96,778,549
(GRCh38/hg38)
Size:
24,001 bases
Orientation:
Minus strand
chr9:99,518,147-99,540,411
(GRCh37/hg19)
Size:
22,265 bases
Orientation:
Minus strand

Genomic View for ZNF510 Gene

Genes around ZNF510 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF510 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF510 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF510 Gene

Proteins for ZNF510 Gene

  • Protein details for ZNF510 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H8-ZN510_HUMAN
    Recommended name:
    Zinc finger protein 510
    Protein Accession:
    Q9Y2H8
    Secondary Accessions:
    • Q5SZP5

    Protein attributes for ZNF510 Gene

    Size:
    683 amino acids
    Molecular mass:
    79142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76816.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF510 Gene

Post-translational modifications for ZNF510 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF510 Gene

No data available for DME Specific Peptides for ZNF510 Gene

Domains & Families for ZNF510 Gene

Gene Families for ZNF510 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF510 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF510 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 510 (Q5SZP4_HUMAN)
  • cDNA FLJ75860, highly similar to Homo sapiens zinc finger protein 510 (ZNF510), mRNA (Q5SZP5_HUMAN)
  • ZNF510 protein (Q6NUI8_HUMAN)
  • Zinc finger protein 510 (ZN510_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2H8

UniProtKB/Swiss-Prot:

ZN510_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF510: view

Function for ZNF510 Gene

Molecular function for ZNF510 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF510 Gene

Gene Ontology (GO) - Molecular Function for ZNF510 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF510: view
genes like me logo Genes that share phenotypes with ZNF510: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF510

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF510 Gene

Localization for ZNF510 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF510 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF510 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF510 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF510: view

Pathways & Interactions for ZNF510 Gene

genes like me logo Genes that share pathways with ZNF510: view

Pathways by source for ZNF510 Gene

2 Reactome pathways for ZNF510 Gene
1 KEGG pathway for ZNF510 Gene

Gene Ontology (GO) - Biological Process for ZNF510 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF510: view

No data available for SIGNOR curated interactions for ZNF510 Gene

Drugs & Compounds for ZNF510 Gene

No Compound Related Data Available

Transcripts for ZNF510 Gene

mRNA/cDNA for ZNF510 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF510

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF510 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4: - -
SP5: - - - - -

Relevant External Links for ZNF510 Gene

GeneLoc Exon Structure for
ZNF510

Expression for ZNF510 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF510 Gene

Protein differential expression in normal tissues from HIPED for ZNF510 Gene

This gene is overexpressed in Liver (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF510 Gene



Protein tissue co-expression partners for ZNF510 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF510

SOURCE GeneReport for Unigene cluster for ZNF510 Gene:

Hs.75264

Evidence on tissue expression from TISSUES for ZNF510 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF510: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF510 Gene

Orthologs for ZNF510 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF510 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF510 30 31
  • 98.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF510 31
  • 75 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 38 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Zfp663 31
  • 33 (a)
ManyToMany
Species where no ortholog for ZNF510 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF510 Gene

ENSEMBL:
Gene Tree for ZNF510 (if available)
TreeFam:
Gene Tree for ZNF510 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF510: view image

Paralogs for ZNF510 Gene

Paralogs for ZNF510 Gene

(503) SIMAP similar genes for ZNF510 Gene using alignment to 3 proteins:

  • ZN510_HUMAN
  • Q5SZP4_HUMAN
  • Q6NUI8_HUMAN

Pseudogenes.org Pseudogenes for ZNF510 Gene

genes like me logo Genes that share paralogs with ZNF510: view

Variants for ZNF510 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF510 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10119874 - p.Gly634Glu
rs10217154 - p.Asn273Lys
rs10217494 - p.Met401Ile
rs11999094 - p.His398Asp
rs2289651 - p.Gln43Arg

Additional dbSNP identifiers (rs#s) for ZNF510 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF510 Gene

Variant ID Type Subtype PubMed ID
nsv1147999 OTHER inversion 26484159
nsv520001 CNV loss 19592680
nsv831660 CNV gain 17160897

Variation tolerance for ZNF510 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF510 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF510

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF510 Gene

Disorders for ZNF510 Gene

Additional Disease Information for ZNF510

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF510 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF510 Gene

Publications for ZNF510 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. (PMID: 19030899) Lei SF … Deng HW (Human genetics 2009) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3

Products for ZNF510 Gene

Sources for ZNF510 Gene