Aliases for ZNF507 Gene

Aliases for ZNF507 Gene

  • Zinc Finger Protein 507 2 3 4 5
  • KIAA1084 4
  • Zfp507 3

External Ids for ZNF507 Gene

Previous GeneCards Identifiers for ZNF507 Gene

  • GC19P037528
  • GC19P037433
  • GC19P032836
  • GC19P029339

Summaries for ZNF507 Gene

GeneCards Summary for ZNF507 Gene

ZNF507 (Zinc Finger Protein 507) is a Protein Coding gene. Diseases associated with ZNF507 include Seckel Syndrome 6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF407.

UniProtKB/Swiss-Prot Summary for ZNF507 Gene

Additional gene information for ZNF507 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF507 Gene

Genomics for ZNF507 Gene

GeneHancer (GH) Regulatory Elements for ZNF507 Gene

Promoters and enhancers for ZNF507 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF507 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF507

Top Transcription factor binding sites by QIAGEN in the ZNF507 gene promoter:
  • Arnt
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • HFH-1

Genomic Locations for ZNF507 Gene

Genomic Locations for ZNF507 Gene
chr19:32,345,594-32,387,667
(GRCh38/hg38)
Size:
42,074 bases
Orientation:
Plus strand
chr19:32,836,500-32,878,573
(GRCh37/hg19)
Size:
42,074 bases
Orientation:
Plus strand

Genomic View for ZNF507 Gene

Genes around ZNF507 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF507 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF507 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF507 Gene

Proteins for ZNF507 Gene

  • Protein details for ZNF507 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCN5-ZN507_HUMAN
    Recommended name:
    Zinc finger protein 507
    Protein Accession:
    Q8TCN5
    Secondary Accessions:
    • A8K911
    • Q2TBF1
    • Q6MZU0
    • Q9UPR8

    Protein attributes for ZNF507 Gene

    Size:
    953 amino acids
    Molecular mass:
    105767 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83036.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD28536.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD28536.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAE45937.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF507 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF507 Gene

Post-translational modifications for ZNF507 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF507 Gene

No data available for DME Specific Peptides for ZNF507 Gene

Domains & Families for ZNF507 Gene

Gene Families for ZNF507 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF507 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF507 Gene

GenScript: Design optimal peptide antigens:
  • ZNF507 protein (B9EGE7_HUMAN)
  • Zinc finger protein 507 (ZN507_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCN5

UniProtKB/Swiss-Prot:

ZN507_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF507: view

Function for ZNF507 Gene

Molecular function for ZNF507 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF507 Gene

Gene Ontology (GO) - Molecular Function for ZNF507 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF507: view
genes like me logo Genes that share phenotypes with ZNF507: view

miRNA for ZNF507 Gene

miRTarBase miRNAs that target ZNF507

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF507 Gene

Localization for ZNF507 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF507 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF507 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF507 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 colocalizes_with nucleus IBA 21873635
GO:0035097 colocalizes_with histone methyltransferase complex IBA 21873635
genes like me logo Genes that share ontologies with ZNF507: view

Pathways & Interactions for ZNF507 Gene

PathCards logo

SuperPathways for ZNF507 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF507 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
genes like me logo Genes that share ontologies with ZNF507: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF507 Gene

Drugs & Compounds for ZNF507 Gene

No Compound Related Data Available

Transcripts for ZNF507 Gene

mRNA/cDNA for ZNF507 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF507 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for ZNF507 Gene

GeneLoc Exon Structure for
ZNF507

Expression for ZNF507 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF507 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF507 Gene



Protein tissue co-expression partners for ZNF507 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF507

SOURCE GeneReport for Unigene cluster for ZNF507 Gene:

Hs.205392

Evidence on tissue expression from TISSUES for ZNF507 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF507: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF507 Gene

Orthologs for ZNF507 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF507 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF507 31 30
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF507 31 30
  • 87.99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF507 31 30
  • 87.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp507 17 31 30
  • 80.69 (n)
rat
(Rattus norvegicus)
Mammalia Zfp507 30
  • 80.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF507 31
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF507 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF507 31 30
  • 69.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF507 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf507 30
  • 62.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32184 30
zebrafish
(Danio rerio)
Actinopterygii znf507 30
  • 53.06 (n)
ZNF507 31
  • 17 (a)
OneToOne
Species where no ortholog for ZNF507 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF507 Gene

ENSEMBL:
Gene Tree for ZNF507 (if available)
TreeFam:
Gene Tree for ZNF507 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF507: view image

Paralogs for ZNF507 Gene

Variants for ZNF507 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF507 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
718321 Benign: not provided 32,354,942(+) A/G SYNONYMOUS_VARIANT
779372 Benign: not provided 32,354,126(+) G/A SYNONYMOUS_VARIANT
786669 Benign: not provided 32,353,736(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF507 Gene

Variation tolerance for ZNF507 Gene

Residual Variation Intolerance Score: 2.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF507 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF507

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF507 Gene

Disorders for ZNF507 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF507 Gene - From: DISEASES

Disorder Aliases PubMed IDs
seckel syndrome 6
  • sckl6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF507

genes like me logo Genes that share disorders with ZNF507: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF507 Gene

Publications for ZNF507 Gene

No publications were found for ZNF507 Gene.

Products for ZNF507 Gene

Sources for ZNF507 Gene