Aliases for ZNF506 Gene

Aliases for ZNF506 Gene

  • Zinc Finger Protein 506 2 3 4 5
  • DKFZp761G1812 2
  • ZNF506 5

External Ids for ZNF506 Gene

Previous GeneCards Identifiers for ZNF506 Gene

  • GC19M019757
  • GC19M019763
  • GC19U900445
  • GC19M019896
  • GC19M019466
  • GC19M019902

Summaries for ZNF506 Gene

GeneCards Summary for ZNF506 Gene

ZNF506 (Zinc Finger Protein 506) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF486.

UniProtKB/Swiss-Prot Summary for ZNF506 Gene

Additional gene information for ZNF506 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF506 Gene

Genomics for ZNF506 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF506 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF506 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF506

Top Transcription factor binding sites by QIAGEN in the ZNF506 gene promoter:
  • En-1
  • Evi-1
  • FOXO1
  • FOXO1a
  • FOXO4
  • Nkx2-2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • Sox5

Genomic Locations for ZNF506 Gene

Genomic Locations for ZNF506 Gene
chr19:19,785,839-19,821,751
(GRCh38/hg38)
Size:
35,913 bases
Orientation:
Minus strand
chr19:19,896,648-19,932,560
(GRCh37/hg19)
Size:
35,913 bases
Orientation:
Minus strand

Genomic View for ZNF506 Gene

Genes around ZNF506 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF506 Gene

Proteins for ZNF506 Gene

  • Protein details for ZNF506 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVG8-ZN506_HUMAN
    Recommended name:
    Zinc finger protein 506
    Protein Accession:
    Q5JVG8
    Secondary Accessions:
    • B3KTH6

    Protein attributes for ZNF506 Gene

    Size:
    444 amino acids
    Molecular mass:
    51537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF506 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF506 Gene

Post-translational modifications for ZNF506 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF506 Gene

Domains & Families for ZNF506 Gene

Gene Families for ZNF506 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF506 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF506 Gene

GenScript: Design optimal peptide antigens:
  • ZNF506 protein (Q4G1C2_HUMAN)
  • Zinc finger protein 506 (ZN506_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5JVG8

UniProtKB/Swiss-Prot:

ZN506_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF506: view

Function for ZNF506 Gene

Molecular function for ZNF506 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF506 Gene

Gene Ontology (GO) - Molecular Function for ZNF506 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF506: view
genes like me logo Genes that share phenotypes with ZNF506: view

Animal Model Products

CRISPR Products

miRNA for ZNF506 Gene

miRTarBase miRNAs that target ZNF506

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF506

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF506 Gene

Localization for ZNF506 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF506 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF506 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF506 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF506: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF506 Gene

Pathways & Interactions for ZNF506 Gene

genes like me logo Genes that share pathways with ZNF506: view

Pathways by source for ZNF506 Gene

2 Reactome pathways for ZNF506 Gene
1 KEGG pathway for ZNF506 Gene

Gene Ontology (GO) - Biological Process for ZNF506 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF506: view

No data available for SIGNOR curated interactions for ZNF506 Gene

Drugs & Compounds for ZNF506 Gene

No Compound Related Data Available

Transcripts for ZNF506 Gene

mRNA/cDNA for ZNF506 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF506

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF506 Gene

No ASD Table

Relevant External Links for ZNF506 Gene

GeneLoc Exon Structure for
ZNF506

Expression for ZNF506 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF506 Gene

Protein differential expression in normal tissues from HIPED for ZNF506 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF506 Gene



Protein tissue co-expression partners for ZNF506 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF506

SOURCE GeneReport for Unigene cluster for ZNF506 Gene:

Hs.351906

Evidence on tissue expression from TISSUES for ZNF506 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF506: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF506 Gene

Orthologs for ZNF506 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF506 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF506 30 31
  • 99.17 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 43 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfp386 31
  • 30 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 29 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Species where no ortholog for ZNF506 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF506 Gene

ENSEMBL:
Gene Tree for ZNF506 (if available)
TreeFam:
Gene Tree for ZNF506 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF506: view image

Paralogs for ZNF506 Gene

Paralogs for ZNF506 Gene

(534) SIMAP similar genes for ZNF506 Gene using alignment to 8 proteins:

  • ZN506_HUMAN
  • F5H490_HUMAN
  • K7EIG2_HUMAN
  • K7EIP5_HUMAN
  • K7ENQ3_HUMAN
  • K7ERD0_HUMAN
  • K7ERD9_HUMAN
  • Q4G1C2_HUMAN

Pseudogenes.org Pseudogenes for ZNF506 Gene

genes like me logo Genes that share paralogs with ZNF506: view

Variants for ZNF506 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF506 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs16996376 - p.Thr189Pro

Additional dbSNP identifiers (rs#s) for ZNF506 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF506 Gene

Variant ID Type Subtype PubMed ID
esv2665024 CNV deletion 23128226
esv2669979 CNV deletion 23128226
esv2718296 CNV deletion 23290073
esv3643858 CNV loss 21293372
esv3893168 CNV gain+loss 25118596
nsv1127664 CNV deletion 24896259
nsv1131410 CNV deletion 24896259
nsv458375 CNV gain 19166990
nsv519535 CNV gain 19592680
nsv578798 CNV gain 21841781
nsv578799 CNV gain 21841781
nsv961192 CNV duplication 23825009

Variation tolerance for ZNF506 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF506 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF506

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF506 Gene

Disorders for ZNF506 Gene

No disorders were found for ZNF506 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF506 Gene

Publications for ZNF506 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. (PMID: 30013081) Nowsheen S … Lou Z (Nature communications 2018) 3
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF506 Gene

Sources for ZNF506 Gene