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Aliases for ZNF503 Gene

Aliases for ZNF503 Gene

  • Zinc Finger Protein 503 2 3 4 5
  • NOLZ1 3 4
  • NOLZ-1 3
  • Nlz2 3

External Ids for ZNF503 Gene

Previous GeneCards Identifiers for ZNF503 Gene

  • GC10M076502
  • GC10M076827
  • GC10M077157
  • GC10M071156
  • GC10M077040
  • GC10M075397

Summaries for ZNF503 Gene

GeneCards Summary for ZNF503 Gene

ZNF503 (Zinc Finger Protein 503) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF703.

UniProtKB/Swiss-Prot for ZNF503 Gene

Additional gene information for ZNF503 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF503 Gene

Genomics for ZNF503 Gene

GeneHancer (GH) Regulatory Elements for ZNF503 Gene

Promoters and enhancers for ZNF503 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF503 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF503 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • Evi-1
  • Hand1
  • Nkx2-5

Genomic Locations for ZNF503 Gene

Genomic Locations for ZNF503 Gene
chr10:75,279,726-75,401,894
(GRCh38/hg38)
Size:
122,169 bases
Orientation:
Minus strand
chr10:77,157,588-77,161,664
(GRCh37/hg19)
Size:
4,077 bases
Orientation:
Minus strand

Genomic View for ZNF503 Gene

Genes around ZNF503 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF503 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF503 Gene

Proteins for ZNF503 Gene

  • Protein details for ZNF503 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F45-ZN503_HUMAN
    Recommended name:
    Zinc finger protein 503
    Protein Accession:
    Q96F45
    Secondary Accessions:
    • Q8NAC5
    • Q96E25
    • Q96IJ0

    Protein attributes for ZNF503 Gene

    Size:
    646 amino acids
    Molecular mass:
    62555 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03999.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF503 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF503 Gene

Post-translational modifications for ZNF503 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF503 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF503 Gene

Domains & Families for ZNF503 Gene

Gene Families for ZNF503 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF503 Gene

Suggested Antigen Peptide Sequences for ZNF503 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 503 (ZN503_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96F45

UniProtKB/Swiss-Prot:

ZN503_HUMAN :
  • Belongs to the Elbow/Noc family.
Family:
  • Belongs to the Elbow/Noc family.
genes like me logo Genes that share domains with ZNF503: view

Function for ZNF503 Gene

Molecular function for ZNF503 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF503 Gene

Gene Ontology (GO) - Molecular Function for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF503: view
genes like me logo Genes that share phenotypes with ZNF503: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF503

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF503 Gene

Localization for ZNF503 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF503 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF503 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF503: view

Pathways & Interactions for ZNF503 Gene

PathCards logo

SuperPathways for ZNF503 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 20735826
GO:0010629 negative regulation of gene expression IDA 20735826
GO:0061351 neural precursor cell proliferation IEA --
GO:0070315 G1 to G0 transition involved in cell differentiation IEA,IDA 20735826
genes like me logo Genes that share ontologies with ZNF503: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF503 Gene

Drugs & Compounds for ZNF503 Gene

No Compound Related Data Available

Transcripts for ZNF503 Gene

mRNA/cDNA for ZNF503 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF503 Gene

Zinc finger protein 503:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF503

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF503 Gene

No ASD Table

Relevant External Links for ZNF503 Gene

GeneLoc Exon Structure for
ZNF503
ECgene alternative splicing isoforms for
ZNF503

Expression for ZNF503 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF503 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF503 Gene

This gene is overexpressed in Brain (59.0) and Cerebrospinal fluid (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF503 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF503 Gene:

ZNF503

SOURCE GeneReport for Unigene cluster for ZNF503 Gene:

Hs.195710

Evidence on tissue expression from TISSUES for ZNF503 Gene

  • Skin(4.1)
  • Spleen(4.1)
  • Nervous system(3.7)
  • Lung(2.5)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with ZNF503: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF503 Gene

Orthologs for ZNF503 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF503 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF503 35 34
  • 99.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF503 35 34
  • 92.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF503 35 34
  • 92.06 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF503 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp503 17 35 34
  • 89.35 (n)
rat
(Rattus norvegicus)
Mammalia Zfp503 34
  • 89.22 (n)
chicken
(Gallus gallus)
Aves ZNF503 35 34
  • 78.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF503 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf503 34
  • 68.11 (n)
Str.18810 34
zebrafish
(Danio rerio)
Actinopterygii znf503 35 34
  • 69.87 (n)
OneToOne
noz2 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ZNF503 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF503 Gene

ENSEMBL:
Gene Tree for ZNF503 (if available)
TreeFam:
Gene Tree for ZNF503 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF503: view image

Paralogs for ZNF503 Gene

Paralogs for ZNF503 Gene

(1) SIMAP similar genes for ZNF503 Gene using alignment to 1 proteins:

  • ZN503_HUMAN
genes like me logo Genes that share paralogs with ZNF503: view

Variants for ZNF503 Gene

Sequence variations from dbSNP and Humsavar for ZNF503 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000013927 -- 75,313,146(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000016272 -- 75,336,752(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000017022 -- 75,395,923(-) AA/AAA genic_downstream_transcript_variant, intron_variant
rs1000020860 -- 75,402,184(-) G/A upstream_transcript_variant
rs1000040967 -- 75,403,746(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF503 Gene

Variant ID Type Subtype PubMed ID
dgv163n67 CNV gain 20364138
dgv927n100 CNV gain 25217958
dgv928n100 CNV gain 25217958
esv1490079 CNV insertion 17803354
esv2858569 CNV duplication 24192839
esv3379237 CNV insertion 20981092
esv3623849 CNV loss 21293372
esv991439 CNV insertion 20482838
nsv1042547 CNV gain 25217958
nsv1069060 CNV deletion 25765185
nsv1126260 CNV deletion 24896259
nsv7221 CNV insertion 18451855
nsv950978 CNV deletion 24416366

Variation tolerance for ZNF503 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF503 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF503

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF503 Gene

Disorders for ZNF503 Gene

Additional Disease Information for ZNF503

No disorders were found for ZNF503 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF503 Gene

Publications for ZNF503 Gene

  1. Nlz1/Znf703 acts as a repressor of transcription. (PMID: 19014486) Nakamura M … Sagerström CG (BMC developmental biology 2008) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 58
  4. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. (PMID: 28258171) Shahi P … Werb Z (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF503 Gene

Sources for ZNF503 Gene

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