Aliases for ZNF501 Gene

Aliases for ZNF501 Gene

  • Zinc Finger Protein 501 2 3 4 5
  • Zinc Finger Protein 52 2 3 4
  • ZNF52 3 4
  • MGC21738 2
  • ZNF501 5
  • ZNF 3

External Ids for ZNF501 Gene

Previous HGNC Symbols for ZNF501 Gene

  • ZNF52

Previous GeneCards Identifiers for ZNF501 Gene

  • GC03P044731
  • GC03P044746
  • GC03P044771
  • GC03P044794
  • GC03P045171
  • GC03P045204
  • GC03P045224
  • GC03P045286
  • GC03P044834
  • GC03P044842
  • GC03P044913
  • GC03P044950
  • GC03P044994
  • GC03P045033
  • GC03P045072
  • GC03P045108

Summaries for ZNF501 Gene

GeneCards Summary for ZNF501 Gene

ZNF501 (Zinc Finger Protein 501) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF502.

UniProtKB/Swiss-Prot Summary for ZNF501 Gene

  • May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555).

Additional gene information for ZNF501 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF501 Gene

Genomics for ZNF501 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF501 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF501 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF501

Top Transcription factor binding sites by QIAGEN in the ZNF501 gene promoter:
  • ARP-1
  • CUTL1
  • Gfi-1
  • HNF-4alpha1
  • Ik-3
  • Pax-6
  • RFX1
  • Sox9
  • TBP
  • TFIID

Genomic Locations for ZNF501 Gene

Genomic Locations for ZNF501 Gene
chr3:44,729,596-44,737,083
(GRCh38/hg38)
Size:
7,488 bases
Orientation:
Plus strand
chr3:44,771,088-44,778,575
(GRCh37/hg19)
Size:
7,488 bases
Orientation:
Plus strand

Genomic View for ZNF501 Gene

Genes around ZNF501 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF501 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF501 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF501 Gene

Proteins for ZNF501 Gene

  • Protein details for ZNF501 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CX3-ZN501_HUMAN
    Recommended name:
    Zinc finger protein 501
    Protein Accession:
    Q96CX3
    Secondary Accessions:
    • B4DLY7
    • Q96NU9

    Protein attributes for ZNF501 Gene

    Size:
    271 amino acids
    Molecular mass:
    31179 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be due to exon skipping.

    Alternative splice isoforms for ZNF501 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF501 Gene

Post-translational modifications for ZNF501 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF501 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF501 Gene

Domains & Families for ZNF501 Gene

Gene Families for ZNF501 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF501 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF501 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 52 (ZN501_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96CX3

UniProtKB/Swiss-Prot:

ZN501_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF501: view

Function for ZNF501 Gene

Molecular function for ZNF501 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555).
UniProtKB/Swiss-Prot Induction:
Up-regulated by Golgi stress-inducing agent nigericin.

Phenotypes From GWAS Catalog for ZNF501 Gene

Gene Ontology (GO) - Molecular Function for ZNF501 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25556234
genes like me logo Genes that share ontologies with ZNF501: view
genes like me logo Genes that share phenotypes with ZNF501: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF501

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF501 Gene

Localization for ZNF501 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF501 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF501 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF501 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 29851555
GO:0005654 nucleoplasm IBA 21873635
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ZNF501: view

Pathways & Interactions for ZNF501 Gene

PathCards logo

SuperPathways for ZNF501 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF501 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0007030 Golgi organization IMP 29851555
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF501: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF501 Gene

Drugs & Compounds for ZNF501 Gene

No Compound Related Data Available

Transcripts for ZNF501 Gene

mRNA/cDNA for ZNF501 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF501

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF501 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b
SP1: - -
SP2: -
SP3: -

Relevant External Links for ZNF501 Gene

GeneLoc Exon Structure for
ZNF501

Expression for ZNF501 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF501 Gene

Protein differential expression in normal tissues from HIPED for ZNF501 Gene

This gene is overexpressed in Platelet (28.3), CD8 Tcells (25.1), and Testis (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF501 Gene



Protein tissue co-expression partners for ZNF501 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF501

SOURCE GeneReport for Unigene cluster for ZNF501 Gene:

Hs.401045

Evidence on tissue expression from TISSUES for ZNF501 Gene

  • Nervous system(4.6)
  • Adrenal gland(4.2)
  • Skin(2.8)
  • Blood(2.3)
  • Kidney(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZNF501: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF501 Gene

Orthologs for ZNF501 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF501 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF501 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF501 31
  • 92 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-191j3.3 31
  • 44 (a)
ManyToMany
zgc:173575 31
  • 41 (a)
ManyToMany
si:ch73-92e7.6 31
  • 33 (a)
ManyToMany
si:dkey-20i20.8 31
  • 33 (a)
ManyToMany
si:dkey-20i20.10 31
  • 33 (a)
ManyToMany
si:dkey-20i20.3 31
  • 32 (a)
ManyToMany
si:dkey-20i20.9 31
  • 29 (a)
ManyToMany
si:dkey-20i20.7 31
  • 29 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006701 30
  • 54.52 (n)
Species where no ortholog for ZNF501 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF501 Gene

ENSEMBL:
Gene Tree for ZNF501 (if available)
TreeFam:
Gene Tree for ZNF501 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF501: view image

Paralogs for ZNF501 Gene

Paralogs for ZNF501 Gene

(573) SIMAP similar genes for ZNF501 Gene using alignment to 1 proteins:

  • ZN501_HUMAN
genes like me logo Genes that share paralogs with ZNF501: view

Variants for ZNF501 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF501 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs4682752 - p.Met17Val
rs58211979 - p.Ile147Val

Additional dbSNP identifiers (rs#s) for ZNF501 Gene

Variation tolerance for ZNF501 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF501 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF501

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF501 Gene

Disorders for ZNF501 Gene

No disorders were found for ZNF501 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF501 Gene

Publications for ZNF501 Gene

  1. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. (PMID: 29851555) Serebrenik YV … Crews CM (Molecular biology of the cell 2018) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF501 Gene

Sources for ZNF501 Gene