Aliases for ZNF500 Gene

Aliases for ZNF500 Gene

  • Zinc Finger Protein 500 2 3 4 5
  • Zinc Finger Protein With KRAB And SCAN Domains 18 3 4
  • ZKSCAN18 3 4
  • KIAA0557 4
  • ZSCAN50 3

External Ids for ZNF500 Gene

Previous GeneCards Identifiers for ZNF500 Gene

  • GC16M004801
  • GC16M004798
  • GC16M004738

Summaries for ZNF500 Gene

GeneCards Summary for ZNF500 Gene

ZNF500 (Zinc Finger Protein 500) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot Summary for ZNF500 Gene

Additional gene information for ZNF500 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF500 Gene

Genomics for ZNF500 Gene

GeneHancer (GH) Regulatory Elements for ZNF500 Gene

Promoters and enhancers for ZNF500 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF500 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF500 gene promoter:
  • AML1a
  • HEN1
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • SRF

Genomic Locations for ZNF500 Gene

Genomic Locations for ZNF500 Gene
chr16:4,745,987-4,767,624
(GRCh38/hg38)
Size:
21,638 bases
Orientation:
Minus strand
chr16:4,798,240-4,817,625
(GRCh37/hg19)
Size:
19,386 bases
Orientation:
Minus strand

Genomic View for ZNF500 Gene

Genes around ZNF500 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF500 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF500 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF500 Gene

Proteins for ZNF500 Gene

  • Protein details for ZNF500 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60304-ZN500_HUMAN
    Recommended name:
    Zinc finger protein 500
    Protein Accession:
    O60304
    Secondary Accessions:
    • A8K6X7
    • B4DNN9
    • Q0VAL2
    • Q96CQ8
    • Q9BTG0

    Protein attributes for ZNF500 Gene

    Size:
    480 amino acids
    Molecular mass:
    53674 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF500 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF500 Gene

Post-translational modifications for ZNF500 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF500 Gene

Domains & Families for ZNF500 Gene

Gene Families for ZNF500 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF500 Gene

Suggested Antigen Peptide Sequences for ZNF500 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50081, highly similar to Zinc finger protein 500 (B4DNN9_HUMAN)
  • ZNF500 protein (Q0VAL1_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 18 (ZN500_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60304

UniProtKB/Swiss-Prot:

ZN500_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF500: view

Function for ZNF500 Gene

Molecular function for ZNF500 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF500 Gene

Gene Ontology (GO) - Molecular Function for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF500: view
genes like me logo Genes that share phenotypes with ZNF500: view

Animal Model Products

CRISPR Products

miRNA for ZNF500 Gene

miRTarBase miRNAs that target ZNF500

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF500

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF500 Gene

Localization for ZNF500 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF500 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF500 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF500: view

Pathways & Interactions for ZNF500 Gene

PathCards logo

SuperPathways for ZNF500 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF500: view

Pathways by source for ZNF500 Gene

2 Reactome pathways for ZNF500 Gene

Gene Ontology (GO) - Biological Process for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF500: view

No data available for SIGNOR curated interactions for ZNF500 Gene

Drugs & Compounds for ZNF500 Gene

No Compound Related Data Available

Transcripts for ZNF500 Gene

mRNA/cDNA for ZNF500 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF500

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF500 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:

Relevant External Links for ZNF500 Gene

GeneLoc Exon Structure for
ZNF500
ECgene alternative splicing isoforms for
ZNF500

Expression for ZNF500 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF500 Gene

Protein differential expression in normal tissues from HIPED for ZNF500 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF500 Gene



Protein tissue co-expression partners for ZNF500 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF500 Gene:

ZNF500

SOURCE GeneReport for Unigene cluster for ZNF500 Gene:

Hs.513316

Evidence on tissue expression from TISSUES for ZNF500 Gene

  • Nervous system(4.8)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF500: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF500 Gene

Orthologs for ZNF500 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF500 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF500 33 32
  • 98.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF500 33 32
  • 82.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF500 33
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF500 33
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF500 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP92 33
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 38 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 35 (a)
ManyToMany
-- 33
  • 32 (a)
ManyToMany
-- 33
  • 31 (a)
ManyToMany
-- 33
  • 29 (a)
ManyToMany
-- 33
  • 29 (a)
ManyToMany
-- 33
  • 28 (a)
ManyToMany
-- 33
  • 28 (a)
ManyToMany
-- 33
  • 28 (a)
ManyToMany
-- 33
  • 27 (a)
ManyToMany
-- 33
  • 27 (a)
ManyToMany
-- 33
  • 27 (a)
ManyToMany
-- 33
  • 26 (a)
ManyToMany
-- 33
  • 26 (a)
ManyToMany
-- 33
  • 26 (a)
ManyToMany
-- 33
  • 25 (a)
ManyToMany
-- 33
  • 24 (a)
ManyToMany
-- 33
  • 24 (a)
ManyToMany
-- 33
  • 24 (a)
ManyToMany
-- 33
  • 23 (a)
ManyToMany
-- 33
  • 23 (a)
ManyToMany
-- 33
  • 23 (a)
ManyToMany
-- 33
  • 23 (a)
ManyToMany
-- 33
  • 23 (a)
ManyToMany
-- 33
  • 22 (a)
ManyToMany
-- 33
  • 21 (a)
ManyToMany
-- 33
  • 19 (a)
ManyToMany
Species where no ortholog for ZNF500 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF500 Gene

ENSEMBL:
Gene Tree for ZNF500 (if available)
TreeFam:
Gene Tree for ZNF500 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF500: view image

Paralogs for ZNF500 Gene

(392) SIMAP similar genes for ZNF500 Gene using alignment to 8 proteins:

  • ZN500_HUMAN
  • B4DNN9_HUMAN
  • K7EIH1_HUMAN
  • K7EJ94_HUMAN
  • K7EM64_HUMAN
  • K7EPZ1_HUMAN
  • K7ERS9_HUMAN
  • Q0VAL1_HUMAN
genes like me logo Genes that share paralogs with ZNF500: view

Variants for ZNF500 Gene

Sequence variations from dbSNP and Humsavar for ZNF500 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000187045 -- 4,755,800(-) T/C intron_variant
rs1000218095 -- 4,756,054(-) T/C intron_variant
rs1000259365 -- 4,761,950(-) G/A intron_variant
rs1000328107 -- 4,751,474(-) C/G 3_prime_UTR_variant, intron_variant
rs1000401287 -- 4,757,988(-) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF500 Gene

Variant ID Type Subtype PubMed ID
esv2678305 CNV deletion 23128226
esv3637704 CNV gain 21293372
esv3637705 CNV loss 21293372
nsv1046986 CNV gain 25217958
nsv571302 CNV gain 21841781

Variation tolerance for ZNF500 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF500 Gene

Human Gene Mutation Database (HGMD)
ZNF500
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF500

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF500 Gene

Disorders for ZNF500 Gene

Additional Disease Information for ZNF500

No disorders were found for ZNF500 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF500 Gene

Publications for ZNF500 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 56

Products for ZNF500 Gene

Sources for ZNF500 Gene