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Aliases for ZNF500 Gene

Aliases for ZNF500 Gene

  • Zinc Finger Protein 500 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 18 3 4
  • ZKSCAN18 3 4
  • KIAA0557 4
  • ZSCAN50 3

External Ids for ZNF500 Gene

Previous GeneCards Identifiers for ZNF500 Gene

  • GC16M004801
  • GC16M004798
  • GC16M004738

Summaries for ZNF500 Gene

GeneCards Summary for ZNF500 Gene

ZNF500 (Zinc Finger Protein 500) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot for ZNF500 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF500 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF500 Gene

Genomics for ZNF500 Gene

GeneHancer (GH) Regulatory Elements for ZNF500 Gene

Promoters and enhancers for ZNF500 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I004765 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 561.9 +0.2 161 4.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B ZNF500 SEPT12 ROGDI ANKS3 C16orf71 GLYR1 UBN1 SMIM22 SEC14L5 CDIP1
GH16I004270 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.6 +494.9 494909 4.5 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 TFAP4 GC16P004274 ZNF75A ZNF500 CREBBP ANKS3 ENSG00000261938 TIGD7 CLUAP1 ZNF597
GH16I004611 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 44.4 +152.1 152052 9.1 CLOCK ZFP64 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZNF610 GLIS1 MGRN1 GC16M004615 UBALD1 CREBBP ZNF500 ANKS3 UBN1 EEF2KMT HMOX2
GH16I004536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.4 +229.4 229433 2.6 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 CDIP1 C16orf96 ZNF500 NMRAL1 ANKS3 ENSG00000261938 CREBBP EEF2KMT HMOX2 GLIS2-AS1
GH16I004252 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 46.3 +514.0 513975 1.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LINC01569 LOC105371063 CREBBP ZNF500 ZNF263 ENSG00000261938 ZNF597 ZNF75A UBN1 ANKS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF500 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF500 gene promoter:

Genomic Locations for ZNF500 Gene

Genomic Locations for ZNF500 Gene
chr16:4,745,987-4,767,624
(GRCh38/hg38)
Size:
21,638 bases
Orientation:
Minus strand
chr16:4,798,240-4,817,625
(GRCh37/hg19)

Genomic View for ZNF500 Gene

Genes around ZNF500 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF500 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF500 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF500 Gene

Proteins for ZNF500 Gene

  • Protein details for ZNF500 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60304-ZN500_HUMAN
    Recommended name:
    Zinc finger protein 500
    Protein Accession:
    O60304
    Secondary Accessions:
    • A8K6X7
    • B4DNN9
    • Q0VAL2
    • Q96CQ8
    • Q9BTG0

    Protein attributes for ZNF500 Gene

    Size:
    480 amino acids
    Molecular mass:
    53674 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF500 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF500 Gene

Post-translational modifications for ZNF500 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF500 Gene

Domains & Families for ZNF500 Gene

Gene Families for ZNF500 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

O60304

UniProtKB/Swiss-Prot:

ZN500_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF500: view

Function for ZNF500 Gene

Molecular function for ZNF500 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF500 Gene

Gene Ontology (GO) - Molecular Function for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF500: view

Phenotypes for ZNF500 Gene

genes like me logo Genes that share phenotypes with ZNF500: view

Animal Model Products

CRISPR Products

miRNA for ZNF500 Gene

miRTarBase miRNAs that target ZNF500

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF500 Gene

Localization for ZNF500 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF500 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF500 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF500: view

Pathways & Interactions for ZNF500 Gene

SuperPathways for ZNF500 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF500: view

Pathways by source for ZNF500 Gene

2 Reactome pathways for ZNF500 Gene

Gene Ontology (GO) - Biological Process for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF500: view

No data available for SIGNOR curated interactions for ZNF500 Gene

Drugs & Compounds for ZNF500 Gene

No Compound Related Data Available

Transcripts for ZNF500 Gene

Unigene Clusters for ZNF500 Gene

Zinc finger protein 500:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF500 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:

Relevant External Links for ZNF500 Gene

GeneLoc Exon Structure for
ZNF500
ECgene alternative splicing isoforms for
ZNF500

Expression for ZNF500 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF500 Gene

Protein differential expression in normal tissues from HIPED for ZNF500 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF500 Gene



Protein tissue co-expression partners for ZNF500 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF500 Gene:

ZNF500

SOURCE GeneReport for Unigene cluster for ZNF500 Gene:

Hs.513316

Evidence on tissue expression from TISSUES for ZNF500 Gene

  • Nervous system(4.8)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF500: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF500 Gene

Orthologs for ZNF500 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF500 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF500 33 34
  • 98.72 (n)
dog
(Canis familiaris)
Mammalia ZNF500 33 34
  • 82.33 (n)
cow
(Bos Taurus)
Mammalia ZNF500 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF500 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF500 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP92 34
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 19 (a)
ManyToMany
Species where no ortholog for ZNF500 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF500 Gene

ENSEMBL:
Gene Tree for ZNF500 (if available)
TreeFam:
Gene Tree for ZNF500 (if available)

Paralogs for ZNF500 Gene

(392) SIMAP similar genes for ZNF500 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF500: view

Variants for ZNF500 Gene

Sequence variations from dbSNP and Humsavar for ZNF500 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000187045 -- 4,755,800(-) T/C intron_variant
rs1000218095 -- 4,756,054(-) T/C intron_variant
rs1000259365 -- 4,761,950(-) G/A intron_variant
rs1000328107 -- 4,751,474(-) C/G 3_prime_UTR_variant, intron_variant
rs1000401287 -- 4,757,988(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF500 Gene

Variant ID Type Subtype PubMed ID
nsv571302 CNV gain 21841781
nsv1046986 CNV gain 25217958
esv3637705 CNV loss 21293372
esv3637704 CNV gain 21293372
esv2678305 CNV deletion 23128226

Variation tolerance for ZNF500 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF500 Gene

Human Gene Mutation Database (HGMD)
ZNF500
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF500

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF500 Gene

Disorders for ZNF500 Gene

Additional Disease Information for ZNF500

No disorders were found for ZNF500 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF500 Gene

Publications for ZNF500 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ZNF500 Gene

Sources for ZNF500 Gene

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