Aliases for ZNF497 Gene

Aliases for ZNF497 Gene

  • Zinc Finger Protein 497 2 3 4 5
  • Zinc Finger-Like Protein 3
  • FLJ44773 2
  • ZNF497 5

External Ids for ZNF497 Gene

Previous GeneCards Identifiers for ZNF497 Gene

  • GC19M063559
  • GC19M063557
  • GC19M058865
  • GC19M055174

Summaries for ZNF497 Gene

GeneCards Summary for ZNF497 Gene

ZNF497 (Zinc Finger Protein 497) is a Protein Coding gene. Diseases associated with ZNF497 include Chronic Tic Disorder. An important paralog of this gene is ZNF574.

UniProtKB/Swiss-Prot Summary for ZNF497 Gene

Additional gene information for ZNF497 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF497 Gene

Genomics for ZNF497 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF497 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF497 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF497

Top Transcription factor binding sites by QIAGEN in the ZNF497 gene promoter:
  • C/EBPalpha
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx5-1
  • Pbx1a
  • RORalpha1
  • STAT3
  • TBP

Genomic Locations for ZNF497 Gene

Genomic Locations for ZNF497 Gene
chr19:58,354,357-58,362,848
(GRCh38/hg38)
Size:
8,492 bases
Orientation:
Minus strand
chr19:58,865,723-58,874,214
(GRCh37/hg19)
Size:
8,492 bases
Orientation:
Minus strand

Genomic View for ZNF497 Gene

Genes around ZNF497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF497 Gene

Proteins for ZNF497 Gene

  • Protein details for ZNF497 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNH5-ZN497_HUMAN
    Recommended name:
    Zinc finger protein 497
    Protein Accession:
    Q6ZNH5
    Secondary Accessions:
    • Q05AG8
    • Q0VF48
    • Q6ZTD2
    • Q9UIA8

    Protein attributes for ZNF497 Gene

    Size:
    498 amino acids
    Molecular mass:
    54721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF497 Gene

Post-translational modifications for ZNF497 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF497 Gene

No data available for DME Specific Peptides for ZNF497 Gene

Domains & Families for ZNF497 Gene

Gene Families for ZNF497 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF497 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF497 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 497 (ZN497_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNH5

UniProtKB/Swiss-Prot:

ZN497_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF497: view

Function for ZNF497 Gene

Molecular function for ZNF497 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF497 Gene

Gene Ontology (GO) - Molecular Function for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF497: view
genes like me logo Genes that share phenotypes with ZNF497: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF497

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF497 Gene

Localization for ZNF497 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF497 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF497 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF497: view

Pathways & Interactions for ZNF497 Gene

PathCards logo

SuperPathways for ZNF497 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF497: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF497 Gene

Drugs & Compounds for ZNF497 Gene

No Compound Related Data Available

Transcripts for ZNF497 Gene

mRNA/cDNA for ZNF497 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF497

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF497 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5: - - - -

Relevant External Links for ZNF497 Gene

GeneLoc Exon Structure for
ZNF497

Expression for ZNF497 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF497 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF497

SOURCE GeneReport for Unigene cluster for ZNF497 Gene:

Hs.447840

Evidence on tissue expression from TISSUES for ZNF497 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF497: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF497 Gene

Orthologs for ZNF497 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF497 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF497 30 31
  • 99.46 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF497 31
  • 56 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 23 (a)
ManyToMany
Species where no ortholog for ZNF497 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF497 Gene

ENSEMBL:
Gene Tree for ZNF497 (if available)
TreeFam:
Gene Tree for ZNF497 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF497: view image

Paralogs for ZNF497 Gene

(500) SIMAP similar genes for ZNF497 Gene using alignment to 2 proteins:

  • ZN497_HUMAN
  • M0R159_HUMAN
genes like me logo Genes that share paralogs with ZNF497: view

Variants for ZNF497 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF497 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12609654 - p.His174Gln

Additional dbSNP identifiers (rs#s) for ZNF497 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF497 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZNF497 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF497 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF497

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF497 Gene

Disorders for ZNF497 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF497 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic tic disorder
  • chronic motor or vocal tic disorder
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF497: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF497 Gene

Publications for ZNF497 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF497 Gene

Sources for ZNF497 Gene