Aliases for ZNF493 Gene

Aliases for ZNF493 Gene

  • Zinc Finger Protein 493 2 3 4 5

External Ids for ZNF493 Gene

Previous GeneCards Identifiers for ZNF493 Gene

  • GC19P021398
  • GC19P021372
  • GC19P021373
  • GC19P021579
  • GC19P021070

Summaries for ZNF493 Gene

GeneCards Summary for ZNF493 Gene

ZNF493 (Zinc Finger Protein 493) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF43.

UniProtKB/Swiss-Prot Summary for ZNF493 Gene

Additional gene information for ZNF493 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF493 Gene

Genomics for ZNF493 Gene

GeneHancer (GH) Regulatory Elements for ZNF493 Gene

Promoters and enhancers for ZNF493 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J021396 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.3 282 2.8 ZBTB40 EP300 POLR2G SP1 ZFX POLR2A FOS GABPA TAF9B NFYB ZNF493 ENSG00000268119 ZNF708 ZNF100 RPL7AP10 ZNF431 ZNF43 ZNF66 MTDHP4 ENSG00000268555
GH19J021405 Promoter 0.3 EPDnew 500.4 +8.8 8761 0.1 ENSG00000269237 ZNF493 ENSG00000268119 piR-54987-058
GH19J021408 Promoter 0.3 EPDnew 500.4 +11.0 11007 0.1 ZNF493 ENSG00000269237 piR-54987-058
GH19J021504 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 4.7 +108.9 108916 2.6 ZNF217 EP300 POLR2G ZNF10 POLR2A CLOCK AFF1 ZBTB26 SAP30 RFX1 ZNF429 NONHSAG025266.2 ENSG00000268555 ZNF708 ZNF493 ZNF100 ZNF430 piR-54764-325 LINC00664
GH19J021318 Enhancer 1 FANTOM5 Ensembl ENCODE 7.6 -75.8 -75818 7.8 POLR2A NCOR1 RXRA FOXA2 TCF12 TAL1 HDAC2 ZNF384 DPF2 SMARCA4 ZNF708 ENSG00000268119 ZNF738 ZNF493 ENSG00000213976 ZNF429 BNIP3P25 lnc-ZNF738-3 piR-52916-015
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF493 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF493

Top Transcription factor binding sites by QIAGEN in the ZNF493 gene promoter:
  • AREB6
  • En-1
  • Nkx2-2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • POU2F1a
  • Sox5
  • SRF
  • SRF (504 AA)

Genomic Locations for ZNF493 Gene

Genomic Locations for ZNF493 Gene
chr19:21,397,119-21,427,573
(GRCh38/hg38)
Size:
30,455 bases
Orientation:
Plus strand
chr19:21,579,921-21,610,375
(GRCh37/hg19)
Size:
30,455 bases
Orientation:
Plus strand

Genomic View for ZNF493 Gene

Genes around ZNF493 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF493 Gene

Proteins for ZNF493 Gene

  • Protein details for ZNF493 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZR52-ZN493_HUMAN
    Recommended name:
    Zinc finger protein 493
    Protein Accession:
    Q6ZR52
    Secondary Accessions:
    • G5E974
    • Q59GM3
    • Q6ZSF6
    • Q8N1Z6
    • Q8N965
    • Q9BR99

    Protein attributes for ZNF493 Gene

    Size:
    646 amino acids
    Molecular mass:
    75342 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04591.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86997.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92323.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF493 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF493 Gene

Post-translational modifications for ZNF493 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF493 Gene

Domains & Families for ZNF493 Gene

Gene Families for ZNF493 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF493 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF493 Gene

GenScript: Design optimal peptide antigens:
  • ZNF493 protein (Q2M1I7_HUMAN)
  • Zinc finger protein 493 (Q9BR99_HUMAN)
  • Zinc finger protein 493 (ZN493_HUMAN)
genes like me logo Genes that share domains with ZNF493: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF493 Gene

Function for ZNF493 Gene

Molecular function for ZNF493 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF493 Gene

Gene Ontology (GO) - Molecular Function for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF493: view
genes like me logo Genes that share phenotypes with ZNF493: view

miRNA for ZNF493 Gene

miRTarBase miRNAs that target ZNF493

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF493 Gene

Localization for ZNF493 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF493 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF493 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF493: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF493 Gene

Pathways & Interactions for ZNF493 Gene

PathCards logo

SuperPathways for ZNF493 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF493: view

Pathways by source for ZNF493 Gene

2 Reactome pathways for ZNF493 Gene

Interacting Proteins for ZNF493 Gene

;

Gene Ontology (GO) - Biological Process for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF493: view

No data available for SIGNOR curated interactions for ZNF493 Gene

Drugs & Compounds for ZNF493 Gene

No Compound Related Data Available

Transcripts for ZNF493 Gene

mRNA/cDNA for ZNF493 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF493 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10: - - - - - - - - - -

Relevant External Links for ZNF493 Gene

GeneLoc Exon Structure for
ZNF493

Expression for ZNF493 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF493 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF493 Gene

This gene is overexpressed in Brain - Cerebellum (x4.7).

Protein differential expression in normal tissues from HIPED for ZNF493 Gene

This gene is overexpressed in Islet of Langerhans (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF493 Gene



Protein tissue co-expression partners for ZNF493 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF493

SOURCE GeneReport for Unigene cluster for ZNF493 Gene:

Hs.656558

Evidence on tissue expression from TISSUES for ZNF493 Gene

  • Nervous system(4.3)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with ZNF493: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF493 Gene

Orthologs for ZNF493 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF493 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF493 31
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp457 31
  • 51 (a)
ManyToMany
Zfp738 31
  • 47 (a)
ManyToMany
Zfp458 31
  • 47 (a)
ManyToMany
Zfp759 31
  • 46 (a)
ManyToMany
A530054K11Rik 31
  • 39 (a)
ManyToMany
Zfp748 31
  • 37 (a)
ManyToMany
AA987161 31
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF493 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF493 Gene

ENSEMBL:
Gene Tree for ZNF493 (if available)
TreeFam:
Gene Tree for ZNF493 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF493: view image

Paralogs for ZNF493 Gene

Paralogs for ZNF493 Gene

(526) SIMAP similar genes for ZNF493 Gene using alignment to 5 proteins:

  • ZN493_HUMAN
  • M0QXT4_HUMAN
  • M0QY95_HUMAN
  • M0R1U0_HUMAN
  • Q2M1I7_HUMAN

Pseudogenes.org Pseudogenes for ZNF493 Gene

genes like me logo Genes that share paralogs with ZNF493: view

Variants for ZNF493 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF493 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10414834 - p.Leu292Val
rs4621113 - p.Cys195Phe

Additional dbSNP identifiers (rs#s) for ZNF493 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF493 Gene

Variant ID Type Subtype PubMed ID
dgv6320n54 CNV loss 21841781
esv2663001 CNV deletion 23128226
esv2665276 CNV deletion 23128226
esv2718325 CNV deletion 23290073
esv2718330 CNV deletion 23290073
esv2751783 CNV loss 17911159
esv3556174 CNV deletion 23714750
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1140249 OTHER inversion 24896259
nsv1151573 OTHER inversion 26484159
nsv458377 CNV gain 19166990
nsv578809 CNV gain 21841781
nsv578952 CNV gain 21841781
nsv978789 CNV duplication 23825009

Variation tolerance for ZNF493 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF493 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF493 Gene

Disorders for ZNF493 Gene

Additional Disease Information for ZNF493

No disorders were found for ZNF493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF493 Gene

Publications for ZNF493 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (PMID: 28700943) Martin TD … Elledge SJ (Cell reports 2017) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Genome-wide association study of acute post-surgical pain in humans. (PMID: 19207018) Kim H … Dionne RA (Pharmacogenomics 2009) 41 54
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54

Products for ZNF493 Gene

Sources for ZNF493 Gene