Aliases for ZNF492 Gene

Aliases for ZNF492 Gene

  • Zinc Finger Protein 492 2 3 4 5
  • Zinc Finger Protein 115 (Y20) 2 3
  • KIAA1473 2 4
  • ZNF115 3 4
  • Zinc Finger Protein 115 4
  • ZNF492 5

External Ids for ZNF492 Gene

Previous HGNC Symbols for ZNF492 Gene

  • ZNF115

Previous GeneCards Identifiers for ZNF492 Gene

  • GC19P022627
  • GC19P022609
  • GC19P022608
  • GC19P022817

Summaries for ZNF492 Gene

GeneCards Summary for ZNF492 Gene

ZNF492 (Zinc Finger Protein 492) is a Protein Coding gene. Diseases associated with ZNF492 include Familial Cold Autoinflammatory Syndrome 2. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF254.

UniProtKB/Swiss-Prot Summary for ZNF492 Gene

Additional gene information for ZNF492 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF492 Gene

Genomics for ZNF492 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF492 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J022633 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 633.4 +0.2 177 2.6 GABPA PKNOX1 SP2 DDX20 SIN3A ZNF335 ZBTB40 POLR2A ZNF492 LINC01859 piR-31534-332 ZNF99 lnc-ZNF492-2 NONHSAG045689.2-002
GH19J022783 Promoter/Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 25 +149.8 149777 1.4 GATA3 ZNF99 ZNF492 BNIP3P34 lnc-ZNF723-3
GH19J023116 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 7.3 +483.3 483266 2.4 SP1 PKNOX1 POLR2A REST GTF2F1 ZFX ZBTB20 YY1 CHD1 ZNF217 NONHSAG025339.2 piR-38605-004 LINC01859 ZNF492 IPO5P1 BNIP3P37 lnc-ZNF724-4 ZNF730 ZNF724
GH19J023074 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 6.9 +441.3 441277 2.4 POLR2A GTF2F1 YY1 CTCF ESRRA ZBTB5 MLLT1 TFDP1 MAZ ZNF143 ZNF730 ENSG00000267886 ZNF492 ZNF728 ENSG00000267924 piR-57133-314 ZNF724
GH19J023070 Promoter/Enhancer 0.8 Ensembl ENCODE 6.5 +436.5 436477 2 CTCF PTBP1 RAD21 POLR2A ENSG00000269543 ZNF492 ZNF730 LINC01858 ZNF728
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF492 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF492

Top Transcription factor binding sites by QIAGEN in the ZNF492 gene promoter:
  • deltaCREB
  • E2F
  • E2F-1
  • IRF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • RFX1

Genomic Locations for ZNF492 Gene

Genomic Locations for ZNF492 Gene
33,348 bases
Plus strand
33,347 bases
Plus strand

Genomic View for ZNF492 Gene

Genes around ZNF492 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF492 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF492 Gene

Proteins for ZNF492 Gene

  • Protein details for ZNF492 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 492
    Protein Accession:
    Secondary Accessions:
    • Q08EI7
    • Q08EI8

    Protein attributes for ZNF492 Gene

    531 amino acids
    Molecular mass:
    61158 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA95997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF492 Gene

Post-translational modifications for ZNF492 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF492 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF492 Gene

Domains & Families for ZNF492 Gene

Gene Families for ZNF492 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF492 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF492 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 115 (ZN492_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF492: view

Function for ZNF492 Gene

Molecular function for ZNF492 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF492 Gene

Gene Ontology (GO) - Molecular Function for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF492: view

Phenotypes for ZNF492 Gene

genes like me logo Genes that share phenotypes with ZNF492: view

Animal Model Products

CRISPR Products

miRNA for ZNF492 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF492

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF492 Gene

Localization for ZNF492 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF492 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF492 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF492: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF492 Gene

Pathways & Interactions for ZNF492 Gene

genes like me logo Genes that share pathways with ZNF492: view

Pathways by source for ZNF492 Gene

2 Reactome pathways for ZNF492 Gene
1 KEGG pathway for ZNF492 Gene

Interacting Proteins for ZNF492 Gene

Gene Ontology (GO) - Biological Process for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF492: view

No data available for SIGNOR curated interactions for ZNF492 Gene

Drugs & Compounds for ZNF492 Gene

No Compound Related Data Available

Transcripts for ZNF492 Gene

mRNA/cDNA for ZNF492 Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF492

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF492 Gene

No ASD Table

Relevant External Links for ZNF492 Gene

GeneLoc Exon Structure for

Expression for ZNF492 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF492 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF492 Gene

This gene is overexpressed in Testis (x8.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF492

SOURCE GeneReport for Unigene cluster for ZNF492 Gene:


Evidence on tissue expression from TISSUES for ZNF492 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF492: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF492 Gene

Orthologs for ZNF492 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF492 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100611724 30
  • 95.61 (n)
-- 31
  • 90 (a)
(Mus musculus)
Mammalia Zfp493 31
  • 56 (a)
(Bos Taurus)
Mammalia -- 31
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
-- 31
  • 40 (a)
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
-- 31
  • 40 (a)
-- 31
  • 38 (a)
-- 31
  • 33 (a)
-- 31
  • 31 (a)
-- 31
  • 31 (a)
-- 31
  • 30 (a)
-- 31
  • 28 (a)
Species where no ortholog for ZNF492 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF492 Gene

Gene Tree for ZNF492 (if available)
Gene Tree for ZNF492 (if available)
Evolutionary constrained regions (ECRs) for ZNF492: view image

Paralogs for ZNF492 Gene

Paralogs for ZNF492 Gene

(509) SIMAP similar genes for ZNF492 Gene using alignment to 1 proteins:

  • ZN492_HUMAN Pseudogenes for ZNF492 Gene

genes like me logo Genes that share paralogs with ZNF492: view

Variants for ZNF492 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF492 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11672238 - p.Thr106Lys

Additional dbSNP identifiers (rs#s) for ZNF492 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF492 Gene

Variant ID Type Subtype PubMed ID
dgv140n111 CNV duplication 26073780
dgv3n43 CNV gain 19587683
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
esv2236506 CNV deletion 18987734
esv2657662 CNV deletion 23128226
esv2674355 CNV deletion 23128226
esv2718358 CNV deletion 23290073
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3556193 CNV deletion 23714750
esv3643959 CNV loss 21293372
esv3643960 CNV gain 21293372
esv3643962 CNV loss 21293372
esv3643963 CNV loss 21293372
esv3643964 CNV loss 21293372
esv3893182 CNV gain 25118596
esv4924 OTHER complex 18987735
nsv1062447 CNV loss 25217958
nsv1078307 OTHER inversion 25765185
nsv1120056 OTHER inversion 24896259
nsv436853 CNV insertion 17901297
nsv525240 CNV gain 19592680
nsv9683 CNV loss 18304495
nsv9684 CNV loss 18304495
nsv978794 CNV duplication 23825009

Variation tolerance for ZNF492 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF492 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF492 Gene

Disorders for ZNF492 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF492 Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial cold autoinflammatory syndrome 2
  • fcas2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF492

genes like me logo Genes that share disorders with ZNF492: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF492 Gene

Publications for ZNF492 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter. (PMID: 16714237) Lu Z … Redmond TM (Current eye research 2006) 3 23
  3. ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array‑based DNA methylation profiling. (PMID: 31115548) Kim YJ … Kim WJ (Oncology reports 2019) 3
  4. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. (PMID: 24743840) Figueiredo JC … GECCO (PLoS genetics 2014) 3
  5. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PMID: 22331829) Chasman DI … Ridker PM (Circulation. Cardiovascular genetics 2012) 41

Products for ZNF492 Gene

Sources for ZNF492 Gene