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Aliases for ZNF491 Gene

Aliases for ZNF491 Gene

  • Zinc Finger Protein 491 2 3 4 5

External Ids for ZNF491 Gene

Previous GeneCards Identifiers for ZNF491 Gene

  • GC19P011771
  • GC19P011772
  • GC19P011908
  • GC19P011484

Summaries for ZNF491 Gene

GeneCards Summary for ZNF491 Gene

ZNF491 (Zinc Finger Protein 491) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF439.

UniProtKB/Swiss-Prot for ZNF491 Gene

Additional gene information for ZNF491 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF491 Gene

Genomics for ZNF491 Gene

GeneHancer (GH) Regulatory Elements for ZNF491 Gene

Promoters and enhancers for ZNF491 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011797 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 608.9 +1.0 1034 2.6 SP1 ELF3 CTCF CBFA2T2 NKRF CEBPG AHR PPARG SP5 RAD21 ZNF491 GC19P011801 PIR49375 ENSG00000267646 ZNF440 ZNF441 ZNF625-ZNF20 ZNF439 ZNF433-AS1 RNA5SP464
GH19J010834 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.6 -961.3 -961259 3.2 ZNF473 MTA3 SP1 CC2D1A ZFX CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 C19orf38 TMED1 ILF3 KRI1 RAVER1 ZNF627 ZNF491 ZNF441 DNMT1 PRKCSH
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.4 +991.6 991631 16 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 IER2 CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 MRI1
GH19J011086 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.8 -705.3 -705297 11 SP1 ZFX ZNF652 ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 ZNF121 LDLR ILF3 ZNF491 ZNF844 ZNF441 ZNF627 ZNF823 KRI1 ZNF788P C19orf38
GH19J011373 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.3 -421.3 -421347 6.2 CC2D1A SP1 ZFX CTCF CBFA2T2 NKRF POLR2A ZNF121 CEBPG GTF2F1 TMEM205 ENSG00000267277 PIR61774 SWSAP1 ILF3 ZNF136 KRI1 ZNF627 ZNF442 ZNF625
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF491 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF491 Gene

Genomic Locations for ZNF491 Gene
chr19:11,797,667-11,809,622
(GRCh38/hg38)
Size:
11,956 bases
Orientation:
Plus strand
chr19:11,908,482-11,920,437
(GRCh37/hg19)
Size:
11,956 bases
Orientation:
Plus strand

Genomic View for ZNF491 Gene

Genes around ZNF491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF491 Gene

Proteins for ZNF491 Gene

  • Protein details for ZNF491 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8L2-ZN491_HUMAN
    Recommended name:
    Zinc finger protein 491
    Protein Accession:
    Q8N8L2
    Secondary Accessions:
    • Q3MJ35
    • Q8NAT8

    Protein attributes for ZNF491 Gene

    Size:
    437 amino acids
    Molecular mass:
    50950 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03809.1; Type=Erroneous termination; Positions=408; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for ZNF491 Gene

Post-translational modifications for ZNF491 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF491 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF491 Gene

Domains & Families for ZNF491 Gene

Gene Families for ZNF491 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF491 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF491 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56992, highly similar to Zinc finger protein 491 (B4DMI8_HUMAN)
  • Zinc finger protein 491 (ZN491_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8L2

UniProtKB/Swiss-Prot:

ZN491_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF491: view

Function for ZNF491 Gene

Molecular function for ZNF491 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF491 Gene

Gene Ontology (GO) - Molecular Function for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF491: view
genes like me logo Genes that share phenotypes with ZNF491: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF491 - Now 50% OFF >
  • * ZNF491 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF491 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF491 Gene

Localization for ZNF491 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF491 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF491 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF491 Gene

Pathways & Interactions for ZNF491 Gene

PathCards logo

SuperPathways for ZNF491 Gene

No Data Available

Interacting Proteins for ZNF491 Gene

Gene Ontology (GO) - Biological Process for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF491 Gene

Drugs & Compounds for ZNF491 Gene

No Compound Related Data Available

Transcripts for ZNF491 Gene

mRNA/cDNA for ZNF491 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF491 Gene

Zinc finger protein 491:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF491 - Now 50% OFF >
  • * ZNF491 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF491 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF491 Gene

No ASD Table

Relevant External Links for ZNF491 Gene

GeneLoc Exon Structure for
ZNF491
ECgene alternative splicing isoforms for
ZNF491

Expression for ZNF491 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF491 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF491 Gene:

ZNF491

SOURCE GeneReport for Unigene cluster for ZNF491 Gene:

Hs.631634

Evidence on tissue expression from TISSUES for ZNF491 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF491: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF491 Gene

Orthologs for ZNF491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF491 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF491 34
  • 98.09 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 41 (a)
ManyToMany
Species where no ortholog for ZNF491 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF491 Gene

ENSEMBL:
Gene Tree for ZNF491 (if available)
TreeFam:
Gene Tree for ZNF491 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF491: view image

Paralogs for ZNF491 Gene

(471) SIMAP similar genes for ZNF491 Gene using alignment to 2 proteins:

  • ZN491_HUMAN
  • C9IYV0_HUMAN

Pseudogenes.org Pseudogenes for ZNF491 Gene

genes like me logo Genes that share paralogs with ZNF491: view

Variants for ZNF491 Gene

Sequence variations from dbSNP and Humsavar for ZNF491 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000256792 -- 11,804,489(+) C/T intron_variant
rs1000390311 -- 11,799,272(+) A/C intron_variant
rs1000416552 -- 11,797,973(+) T/A upstream_transcript_variant
rs1000442037 -- 11,797,687(+) C/T upstream_transcript_variant
rs1000554720 -- 11,809,158(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF491 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv3643677 CNV gain 21293372
nsv525966 CNV gain 19592680
nsv960790 CNV duplication 23825009

Variation tolerance for ZNF491 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF491

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF491 Gene

Disorders for ZNF491 Gene

Additional Disease Information for ZNF491

No disorders were found for ZNF491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF491 Gene

Publications for ZNF491 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF491 Gene

Sources for ZNF491 Gene

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