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Aliases for ZNF491 Gene

Aliases for ZNF491 Gene

  • Zinc Finger Protein 491 2 3 5

External Ids for ZNF491 Gene

Previous GeneCards Identifiers for ZNF491 Gene

  • GC19P011771
  • GC19P011772
  • GC19P011908
  • GC19P011484

Summaries for ZNF491 Gene

GeneCards Summary for ZNF491 Gene

ZNF491 (Zinc Finger Protein 491) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF433.

UniProtKB/Swiss-Prot for ZNF491 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF491 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF491 Gene

Genomics for ZNF491 Gene

GeneHancer (GH) Regulatory Elements for ZNF491 Gene

Promoters and enhancers for ZNF491 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I011797 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 559 +0.8 797 1.9 PKNOX1 ARID4B SIN3A ZNF48 ETS1 GLIS2 ZNF207 ZNF143 RUNX3 RXRA ZNF491 ENSG00000267646 GC19P011801 PIR49375 ZNF441 ZNF625-ZNF20 ZNF439 ZNF433-AS1 RNA5SP464 ZNF433
GH19I011086 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.6 -705.3 -705297 11 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC LDLR ILF3 RAVER1 ZNF491 ZNF441 KRI1 ZNF700 ZNF844 ZNF627 PPAN
GH19I010834 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 40.6 -961.6 -961642 2.4 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 C19orf38 TMED1 ILF3 ZNF627 ZNF441 ZNF491 KRI1 ILF3-AS1 RAVER1 QTRT1
GH19I011531 Enhancer 1.4 FANTOM5 Ensembl ENCODE 56.5 -265.2 -265229 1.6 PKNOX1 ATF1 ZNF493 ZFP64 ZNF213 FOS ZNF202 ZC3H11A REST ZNF623 ZNF627 ILF3 ZNF136 ZNF442 ZNF844 ZNF625 KRI1 ZNF44 ZNF441 ZNF709
GH19I011343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.6 -451.9 -451921 5 CLOCK FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MEF2D CCDC159 PIR44072 RAB3D PIR37751 TMEM205 ILF3 ZNF136 KRI1 ZNF627 ZNF844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF491 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF491 Gene

Genomic Locations for ZNF491 Gene
11,956 bases
Plus strand

Genomic View for ZNF491 Gene

Genes around ZNF491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF491 Gene

Proteins for ZNF491 Gene

  • Protein details for ZNF491 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 491
    Protein Accession:
    Secondary Accessions:
    • Q3MJ35
    • Q8NAT8

    Protein attributes for ZNF491 Gene

    437 amino acids
    Molecular mass:
    50950 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03809.1; Type=Erroneous termination; Positions=408; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for ZNF491 Gene

Post-translational modifications for ZNF491 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF491 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF491 Gene

Domains & Families for ZNF491 Gene

Gene Families for ZNF491 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF491 Gene


Suggested Antigen Peptide Sequences for ZNF491 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF491: view

Function for ZNF491 Gene

Molecular function for ZNF491 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF491 Gene

Gene Ontology (GO) - Molecular Function for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF491: view

Phenotypes for ZNF491 Gene

GenomeRNAi human phenotypes for ZNF491:
genes like me logo Genes that share phenotypes with ZNF491: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF491 Gene

Localization for ZNF491 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF491 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF491 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF491 Gene

Pathways & Interactions for ZNF491 Gene

SuperPathways for ZNF491 Gene

No Data Available

Interacting Proteins for ZNF491 Gene

Gene Ontology (GO) - Biological Process for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF491 Gene

Drugs & Compounds for ZNF491 Gene

No Compound Related Data Available

Transcripts for ZNF491 Gene

mRNA/cDNA for ZNF491 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF491 Gene

Zinc finger protein 491:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF491 Gene

No ASD Table

Relevant External Links for ZNF491 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF491 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF491 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF491 Gene:


SOURCE GeneReport for Unigene cluster for ZNF491 Gene:


Evidence on tissue expression from TISSUES for ZNF491 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF491: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF491 Gene

Orthologs for ZNF491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF491 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF491 33
  • 98.09 (n)
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
Species where no ortholog for ZNF491 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF491 Gene

Gene Tree for ZNF491 (if available)
Gene Tree for ZNF491 (if available)

Paralogs for ZNF491 Gene

(471) SIMAP similar genes for ZNF491 Gene using alignment to 2 proteins: Pseudogenes for ZNF491 Gene

genes like me logo Genes that share paralogs with ZNF491: view

Variants for ZNF491 Gene

Sequence variations from dbSNP and Humsavar for ZNF491 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000256792 -- 11,804,489(+) C/T intron_variant
rs1000390311 -- 11,799,272(+) A/C intron_variant
rs1000416552 -- 11,797,973(+) T/A upstream_transcript_variant
rs1000442037 -- 11,797,687(+) C/T upstream_transcript_variant
rs1000554720 -- 11,809,158(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF491 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv3643677 CNV gain 21293372
nsv525966 CNV gain 19592680
nsv960790 CNV duplication 23825009

Variation tolerance for ZNF491 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF491 Gene

Disorders for ZNF491 Gene

Additional Disease Information for ZNF491

No disorders were found for ZNF491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF491 Gene

Publications for ZNF491 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF491 Gene

Sources for ZNF491 Gene

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