Aliases for ZNF491 Gene

Aliases for ZNF491 Gene

  • Zinc Finger Protein 491 2 3 4 5

External Ids for ZNF491 Gene

Previous GeneCards Identifiers for ZNF491 Gene

  • GC19P011771
  • GC19P011772
  • GC19P011908
  • GC19P011484

Summaries for ZNF491 Gene

GeneCards Summary for ZNF491 Gene

ZNF491 (Zinc Finger Protein 491) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF440.

UniProtKB/Swiss-Prot Summary for ZNF491 Gene

Additional gene information for ZNF491 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF491 Gene

Genomics for ZNF491 Gene

GeneHancer (GH) Regulatory Elements for ZNF491 Gene

Promoters and enhancers for ZNF491 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF491 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF491

Genomic Locations for ZNF491 Gene

Genomic Locations for ZNF491 Gene
11,956 bases
Plus strand
11,956 bases
Plus strand

Genomic View for ZNF491 Gene

Genes around ZNF491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF491 Gene

Proteins for ZNF491 Gene

  • Protein details for ZNF491 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 491
    Protein Accession:
    Secondary Accessions:
    • Q3MJ35
    • Q8NAT8

    Protein attributes for ZNF491 Gene

    437 amino acids
    Molecular mass:
    50950 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03809.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF491 Gene

Post-translational modifications for ZNF491 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF491 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF491 Gene

Domains & Families for ZNF491 Gene

Gene Families for ZNF491 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF491 Gene


Suggested Antigen Peptide Sequences for ZNF491 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56992, highly similar to Zinc finger protein 491 (B4DMI8_HUMAN)
  • Zinc finger protein 491 (ZN491_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF491: view

Function for ZNF491 Gene

Molecular function for ZNF491 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF491 Gene

Gene Ontology (GO) - Molecular Function for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF491: view
genes like me logo Genes that share phenotypes with ZNF491: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF491 Gene

Localization for ZNF491 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF491 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF491 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF491 Gene

Pathways & Interactions for ZNF491 Gene

PathCards logo

SuperPathways for ZNF491 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF491 Gene

Drugs & Compounds for ZNF491 Gene

No Compound Related Data Available

Transcripts for ZNF491 Gene

mRNA/cDNA for ZNF491 Gene

7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF491 Gene

No ASD Table

Relevant External Links for ZNF491 Gene

GeneLoc Exon Structure for

Expression for ZNF491 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF491 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF491

SOURCE GeneReport for Unigene cluster for ZNF491 Gene:


Evidence on tissue expression from TISSUES for ZNF491 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF491: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF491 Gene

Orthologs for ZNF491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF491 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF491 30
  • 98.09 (n)
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
Species where no ortholog for ZNF491 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF491 Gene

Gene Tree for ZNF491 (if available)
Gene Tree for ZNF491 (if available)
Evolutionary constrained regions (ECRs) for ZNF491: view image

Paralogs for ZNF491 Gene

(471) SIMAP similar genes for ZNF491 Gene using alignment to 2 proteins:

  • ZN491_HUMAN
  • C9IYV0_HUMAN Pseudogenes for ZNF491 Gene

genes like me logo Genes that share paralogs with ZNF491: view

Variants for ZNF491 Gene

Additional dbSNP identifiers (rs#s) for ZNF491 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF491 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv3643677 CNV gain 21293372
nsv525966 CNV gain 19592680
nsv960790 CNV duplication 23825009

Variation tolerance for ZNF491 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF491 Gene

Disorders for ZNF491 Gene

Additional Disease Information for ZNF491

No disorders were found for ZNF491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF491 Gene

Publications for ZNF491 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for ZNF491 Gene