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Aliases for ZNF490 Gene

Aliases for ZNF490 Gene

  • Zinc Finger Protein 490 2 3 4 5
  • KIAA1198 4

External Ids for ZNF490 Gene

Previous GeneCards Identifiers for ZNF490 Gene

  • GC19M012547
  • GC19M012687
  • GC19M012259

Summaries for ZNF490 Gene

GeneCards Summary for ZNF490 Gene

ZNF490 (Zinc Finger Protein 490) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF699.

UniProtKB/Swiss-Prot for ZNF490 Gene

Additional gene information for ZNF490 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF490 Gene

Genomics for ZNF490 Gene

GeneHancer (GH) Regulatory Elements for ZNF490 Gene

Promoters and enhancers for ZNF490 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012609 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 623.4 +27.9 27923 5.2 SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A MLLT1 CEBPG RERE ZNF490 ZNF791 PIR37932 ZNF136 ZNF44 ZNF442 ZNF844 ZNF20 ZNF564 ZNF700
GH19J012639 Promoter/Enhancer 1.4 Ensembl ENCODE 600.7 -0.1 -136 0.9 CC2D1A CTCF ELF3 MLLT1 GTF2F1 TRIM24 CREM RAD21 IKZF1 IKZF2 LOC105372279 ZNF490
GH19J013148 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.7 -513.3 -513294 10.8 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 MNT SIX5 ZNF148 NKRF STX10 ENSG00000267598 IER2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS RFX1
GH19J012664 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.2 -27.6 -27581 6.6 SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A GTF2F1 CSDE1 ZNF687 WDR83OS ENSG00000269590 GC19M012663 MAN2B1 WDR83 ZNF490 ZNF20 ZNF44 TRMT1 ZNF136
GH19J011923 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.1 +714.5 714497 4.4 HDGF ZNF652 ZFX SP1 CTCF ZNF148 NKRF POLR2A ZNF121 CEBPG ZNF700 ENSG00000267179 ZNF627 ZNF136 ZNF44 ZNF763 ZNF20 ZNF564 ZNF442 ZNF791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF490 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF490 Gene

Genomic Locations for ZNF490 Gene
63,999 bases
Minus strand
63,993 bases
Minus strand

Genomic View for ZNF490 Gene

Genes around ZNF490 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF490 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF490 Gene

Proteins for ZNF490 Gene

  • Protein details for ZNF490 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 490
    Protein Accession:

    Protein attributes for ZNF490 Gene

    529 amino acids
    Molecular mass:
    61340 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA86512.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF490 Gene

Post-translational modifications for ZNF490 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF490 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF490 Gene

Domains & Families for ZNF490 Gene

Gene Families for ZNF490 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF490 Gene

Suggested Antigen Peptide Sequences for ZNF490 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 490 (ZN490_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF490: view

Function for ZNF490 Gene

Molecular function for ZNF490 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF490 Gene

Gene Ontology (GO) - Molecular Function for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF490: view
genes like me logo Genes that share phenotypes with ZNF490: view

Animal Model Products

CRISPR Products

miRNA for ZNF490 Gene

miRTarBase miRNAs that target ZNF490

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF490 - Now 50% OFF >
  • * ZNF490 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF490 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF490 Gene

Localization for ZNF490 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF490 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF490 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF490: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF490 Gene

Pathways & Interactions for ZNF490 Gene

genes like me logo Genes that share pathways with ZNF490: view

Pathways by source for ZNF490 Gene

2 Reactome pathways for ZNF490 Gene
1 KEGG pathway for ZNF490 Gene

Gene Ontology (GO) - Biological Process for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF490: view

No data available for SIGNOR curated interactions for ZNF490 Gene

Drugs & Compounds for ZNF490 Gene

No Compound Related Data Available

Transcripts for ZNF490 Gene

mRNA/cDNA for ZNF490 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF490 Gene

Zinc finger protein 490:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF490 - Now 50% OFF >
  • * ZNF490 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF490 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF490 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -

Relevant External Links for ZNF490 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF490 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF490 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF490 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF490 Gene:


SOURCE GeneReport for Unigene cluster for ZNF490 Gene:


Evidence on tissue expression from TISSUES for ZNF490 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF490: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF490 Gene

Orthologs for ZNF490 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF490 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF490 35 34
  • 99.81 (n)
(Bos Taurus)
Mammalia -- 35
  • 52 (a)
Species where no ortholog for ZNF490 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF490 Gene

Gene Tree for ZNF490 (if available)
Gene Tree for ZNF490 (if available)
Evolutionary constrained regions (ECRs) for ZNF490: view image

Paralogs for ZNF490 Gene

Paralogs for ZNF490 Gene

(449) SIMAP similar genes for ZNF490 Gene using alignment to 3 proteins:

  • ZN490_HUMAN
genes like me logo Genes that share paralogs with ZNF490: view

Variants for ZNF490 Gene

Sequence variations from dbSNP and Humsavar for ZNF490 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000000748 -- 12,579,952(-) A/T 3_prime_UTR_variant
rs1000166965 -- 12,601,434(-) C/T intron_variant
rs1000217519 -- 12,605,046(-) G/A intron_variant
rs1000275387 -- 12,601,767(-) C/T intron_variant
rs1000362989 -- 12,611,378(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF490 Gene

Variant ID Type Subtype PubMed ID
dgv3436n100 CNV gain 25217958
dgv3437n100 CNV gain 25217958
dgv54n16 CNV deletion 17901297
dgv6270n54 CNV gain 21841781
dgv6271n54 CNV gain 21841781
dgv6272n54 CNV gain+loss 21841781
dgv79n73 CNV deletion 24416366
esv23136 CNV gain+loss 19812545
esv2657078 CNV deletion 23128226
esv3556048 CNV deletion 23714750
esv3583253 CNV loss 25503493
esv3643709 CNV loss 21293372
esv996849 CNV gain 20482838
esv997496 CNV deletion 20482838
nsv1071146 CNV deletion 25765185
nsv1125434 CNV deletion 24896259
nsv1151821 CNV deletion 26484159
nsv1160586 CNV duplication 26073780
nsv2419 CNV deletion 18451855
nsv498893 CNV loss 21111241
nsv510755 CNV deletion 20534489
nsv512563 CNV loss 21212237
nsv514889 CNV loss 21397061
nsv578634 CNV loss 21841781
nsv820210 CNV gain 19587683
nsv821459 CNV deletion 20802225
nsv828441 CNV loss 20364138
nsv828443 CNV loss 20364138

Variation tolerance for ZNF490 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF490 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF490 Gene

Disorders for ZNF490 Gene

Additional Disease Information for ZNF490

No disorders were found for ZNF490 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF490 Gene

Publications for ZNF490 Gene

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y … Zhang H (Genetic epidemiology 2011) 3 45 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 58

Products for ZNF490 Gene

Sources for ZNF490 Gene