Aliases for ZNF490 Gene

Aliases for ZNF490 Gene

  • Zinc Finger Protein 490 2 3 4 5
  • KIAA1198 2 4
  • ZNF490 5

External Ids for ZNF490 Gene

Previous GeneCards Identifiers for ZNF490 Gene

  • GC19M012547
  • GC19M012687
  • GC19M012259

Summaries for ZNF490 Gene

GeneCards Summary for ZNF490 Gene

ZNF490 (Zinc Finger Protein 490) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF699.

UniProtKB/Swiss-Prot Summary for ZNF490 Gene

Additional gene information for ZNF490 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF490 Gene

Genomics for ZNF490 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF490 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF490 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF490

Genomic Locations for ZNF490 Gene

Genomic Locations for ZNF490 Gene
chr19:12,576,100-12,640,098
(GRCh38/hg38)
Size:
63,999 bases
Orientation:
Minus strand
chr19:12,686,920-12,750,912
(GRCh37/hg19)
Size:
63,993 bases
Orientation:
Minus strand

Genomic View for ZNF490 Gene

Genes around ZNF490 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF490 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF490 Gene

Proteins for ZNF490 Gene

  • Protein details for ZNF490 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULM2-ZN490_HUMAN
    Recommended name:
    Zinc finger protein 490
    Protein Accession:
    Q9ULM2

    Protein attributes for ZNF490 Gene

    Size:
    529 amino acids
    Molecular mass:
    61340 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86512.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF490 Gene

Post-translational modifications for ZNF490 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF490 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF490 Gene

Domains & Families for ZNF490 Gene

Gene Families for ZNF490 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF490 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF490 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 490 (ZN490_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULM2

UniProtKB/Swiss-Prot:

ZN490_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF490: view

Function for ZNF490 Gene

Molecular function for ZNF490 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF490 Gene

Gene Ontology (GO) - Molecular Function for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF490: view
genes like me logo Genes that share phenotypes with ZNF490: view

Animal Model Products

CRISPR Products

miRNA for ZNF490 Gene

miRTarBase miRNAs that target ZNF490

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF490

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF490 Gene

Localization for ZNF490 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF490 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF490 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF490: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF490 Gene

Pathways & Interactions for ZNF490 Gene

genes like me logo Genes that share pathways with ZNF490: view

Pathways by source for ZNF490 Gene

2 Reactome pathways for ZNF490 Gene
1 KEGG pathway for ZNF490 Gene

Gene Ontology (GO) - Biological Process for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF490: view

No data available for SIGNOR curated interactions for ZNF490 Gene

Drugs & Compounds for ZNF490 Gene

No Compound Related Data Available

Transcripts for ZNF490 Gene

mRNA/cDNA for ZNF490 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF490

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF490 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3:

Relevant External Links for ZNF490 Gene

GeneLoc Exon Structure for
ZNF490

Expression for ZNF490 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF490 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF490 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF490

SOURCE GeneReport for Unigene cluster for ZNF490 Gene:

Hs.655860

Evidence on tissue expression from TISSUES for ZNF490 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF490: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF490 Gene

Orthologs for ZNF490 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF490 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF490 30 31
  • 99.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
ManyToMany
Species where no ortholog for ZNF490 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF490 Gene

ENSEMBL:
Gene Tree for ZNF490 (if available)
TreeFam:
Gene Tree for ZNF490 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF490: view image

Paralogs for ZNF490 Gene

Paralogs for ZNF490 Gene

(449) SIMAP similar genes for ZNF490 Gene using alignment to 3 proteins:

  • ZN490_HUMAN
  • C9JID3_HUMAN
  • F8WDW6_HUMAN
genes like me logo Genes that share paralogs with ZNF490: view

Variants for ZNF490 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF490 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
731849 Benign: not provided 12,581,475(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF490 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF490 Gene

Variant ID Type Subtype PubMed ID
dgv3436n100 CNV gain 25217958
dgv3437n100 CNV gain 25217958
dgv54n16 CNV deletion 17901297
dgv6270n54 CNV gain 21841781
dgv6271n54 CNV gain 21841781
dgv6272n54 CNV gain+loss 21841781
dgv79n73 CNV deletion 24416366
esv23136 CNV gain+loss 19812545
esv2657078 CNV deletion 23128226
esv3556048 CNV deletion 23714750
esv3583253 CNV loss 25503493
esv3643709 CNV loss 21293372
esv996849 CNV gain 20482838
esv997496 CNV deletion 20482838
nsv1071146 CNV deletion 25765185
nsv1125434 CNV deletion 24896259
nsv1151821 CNV deletion 26484159
nsv1160586 CNV duplication 26073780
nsv2419 CNV deletion 18451855
nsv498893 CNV loss 21111241
nsv510755 CNV deletion 20534489
nsv512563 CNV loss 21212237
nsv514889 CNV loss 21397061
nsv578634 CNV loss 21841781
nsv820210 CNV gain 19587683
nsv821459 CNV deletion 20802225
nsv828441 CNV loss 20364138
nsv828443 CNV loss 20364138

Variation tolerance for ZNF490 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF490 Gene

Human Gene Mutation Database (HGMD)
ZNF490
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF490

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF490 Gene

Disorders for ZNF490 Gene

Additional Disease Information for ZNF490

No disorders were found for ZNF490 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF490 Gene

Publications for ZNF490 Gene

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y … Zhang H (Genetic epidemiology 2011) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for ZNF490 Gene