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Aliases for ZNF488 Gene

Aliases for ZNF488 Gene

  • Zinc Finger Protein 488 2 3 4 5

External Ids for ZNF488 Gene

Previous GeneCards Identifiers for ZNF488 Gene

  • GC10P047749
  • GC10P047975
  • GC10P048355
  • GC10P043107

Summaries for ZNF488 Gene

GeneCards Summary for ZNF488 Gene

ZNF488 (Zinc Finger Protein 488) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PRDM8.

UniProtKB/Swiss-Prot for ZNF488 Gene

  • Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.

Additional gene information for ZNF488 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF488 Gene

Genomics for ZNF488 Gene

GeneHancer (GH) Regulatory Elements for ZNF488 Gene

Promoters and enhancers for ZNF488 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J047383 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 610.6 -0.1 -68 2.4 HDGF SP1 ZSCAN21 SP7 POLR2A KLF14 PRDM1 MZF1 EGR1 GLIS2 ZNF488 BMS1P1 LOC105378292
GH10J047420 Enhancer 0.8 Ensembl ENCODE 11.7 -36.8 -36797 1.9 SP7 CREB1 GLIS2 ZIC2 ZNF629 CEBPB JUN JUND FOS FOSL1 AGAP9 ZNF488 GDF2 LOC105378292 PIR39362
GH10J047377 Enhancer 1 Ensembl ENCODE 4.7 +6.8 6788 1.9 MYC ZSCAN4 ZNF776 POLR2A CTBP1 ZNF239 SCRT2 ZXDB ZBTB10 PKNOX1 AGAP9 ENSG00000229227 BMS1P1 MAPK8 BMS1P2 ZNF488 RBP3
GH10J047363 Enhancer 0.7 Ensembl ENCODE 5.9 +20.1 20100 1.9 SCRT2 HNF4A SMAD4 RARA ZNF488 RBP3
GH10J047372 Enhancer 0.3 Ensembl 12.5 +11.2 11232 2.2 ZKSCAN1 ZNF488 RBP3 GDF2 GDF10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF488 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF488 gene promoter:
  • AREB6
  • Evi-1
  • Msx-1
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZNF488 Gene

Genomic Locations for ZNF488 Gene
chr10:47,365,496-47,384,333
(GRCh38/hg38)
Size:
18,838 bases
Orientation:
Minus strand
chr10:48,355,024-48,373,866
(GRCh37/hg19)
Size:
18,843 bases
Orientation:
Plus strand

Genomic View for ZNF488 Gene

Genes around ZNF488 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF488 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF488 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF488 Gene

Proteins for ZNF488 Gene

  • Protein details for ZNF488 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MN9-ZN488_HUMAN
    Recommended name:
    Zinc finger protein 488
    Protein Accession:
    Q96MN9
    Secondary Accessions:
    • Q05CE0

    Protein attributes for ZNF488 Gene

    Size:
    340 amino acids
    Molecular mass:
    36962 Da
    Quaternary structure:
    • Interacts with OLIG2.

    Alternative splice isoforms for ZNF488 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF488 Gene

Post-translational modifications for ZNF488 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF488 Gene

Domains & Families for ZNF488 Gene

Gene Families for ZNF488 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ZNF488 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF488 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 488 (A2AH61_HUMAN)
  • Zinc finger protein 488 (A2AH62_HUMAN)
  • Zinc finger protein 488 (A2AH63_HUMAN)
  • Zinc finger protein 488 (A2AH64_HUMAN)
  • Zinc finger protein 488 (A2AH65_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96MN9

UniProtKB/Swiss-Prot:

ZN488_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF488: view

Function for ZNF488 Gene

Molecular function for ZNF488 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.

Phenotypes From GWAS Catalog for ZNF488 Gene

Gene Ontology (GO) - Molecular Function for ZNF488 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16713569
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF488: view
genes like me logo Genes that share phenotypes with ZNF488: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF488

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF488 Gene

Localization for ZNF488 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF488 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF488 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF488 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF488: view

Pathways & Interactions for ZNF488 Gene

PathCards logo

SuperPathways for ZNF488 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF488 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0014003 oligodendrocyte development IBA 21873635
genes like me logo Genes that share ontologies with ZNF488: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF488 Gene

Drugs & Compounds for ZNF488 Gene

No Compound Related Data Available

Transcripts for ZNF488 Gene

mRNA/cDNA for ZNF488 Gene

Unigene Clusters for ZNF488 Gene

Zinc finger protein 488:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF488

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF488 Gene

No ASD Table

Relevant External Links for ZNF488 Gene

GeneLoc Exon Structure for
ZNF488
ECgene alternative splicing isoforms for
ZNF488

Expression for ZNF488 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF488 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF488 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.9), Brain - Substantia nigra (x7.4), and Brain - Hippocampus (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of ZNF488 Gene:

ZNF488

SOURCE GeneReport for Unigene cluster for ZNF488 Gene:

Hs.27788

Evidence on tissue expression from TISSUES for ZNF488 Gene

  • Nervous system(4.9)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with ZNF488: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF488 Gene

Orthologs for ZNF488 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF488 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF488 34
  • 95.49 (n)
cow
(Bos Taurus)
Mammalia ZNF488 34
  • 77.3 (n)
dog
(Canis familiaris)
Mammalia ZNF488 34
  • 74.97 (n)
rat
(Rattus norvegicus)
Mammalia Zfp488 34
  • 69.38 (n)
mouse
(Mus musculus)
Mammalia Zfp488 17 34
  • 69.28 (n)
Species where no ortholog for ZNF488 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF488 Gene

ENSEMBL:
Gene Tree for ZNF488 (if available)
TreeFam:
Gene Tree for ZNF488 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF488: view image

Paralogs for ZNF488 Gene

Paralogs for ZNF488 Gene

genes like me logo Genes that share paralogs with ZNF488: view

Variants for ZNF488 Gene

Sequence variations from dbSNP and Humsavar for ZNF488 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000011649 -- 47,384,820(-) C/G/T upstream_transcript_variant
rs1000205387 -- 47,367,803(-) C/T 3_prime_UTR_variant
rs1000253876 -- 47,367,543(-) C/T 3_prime_UTR_variant
rs1000351922 -- 47,373,293(-) C/T intron_variant
rs1000902817 -- 47,377,610(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF488 Gene

Variant ID Type Subtype PubMed ID
dgv417e59 CNV duplication 20981092
esv3435281 CNV insertion 20981092
nsv831861 CNV loss 17160897

Variation tolerance for ZNF488 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF488 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF488

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF488 Gene

Disorders for ZNF488 Gene

Additional Disease Information for ZNF488

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF488 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF488 Gene

Publications for ZNF488 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF488 Gene

Sources for ZNF488 Gene

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