Aliases for ZNF487 Gene

Aliases for ZNF487 Gene

  • Zinc Finger Protein 487 2 3 5
  • Zinc Finger Protein 487, Pseudogene 2 3
  • Putative Zinc Finger Protein 487 3 4
  • KRAB Domain Only Protein 1 3 4
  • KRAB Domain Only 1 2 3
  • ZNF487P 3 4
  • KRBO1 3 4
  • ZNF487 5

External Ids for ZNF487 Gene

Previous HGNC Symbols for ZNF487 Gene

  • KRBO1
  • ZNF487P

Previous GeneCards Identifiers for ZNF487 Gene

  • GC10P043252
  • GC10P043933

Summaries for ZNF487 Gene

GeneCards Summary for ZNF487 Gene

ZNF487 (Zinc Finger Protein 487) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot Summary for ZNF487 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF487 Gene

Genomics for ZNF487 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF487 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J043435 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 250.7 0.0 -13 2.9 TBP ZBTB10 MXD4 MNT IKZF1 SMAD5 IRF2 MBD2 POLR2A BHLHE40 HSALNG0077555 ZNF487 lnc-HNRNPF-1 lnc-FXYD4-4 ENSG00000230555 ZNF33B HNRNPF
GH10J042781 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.1 -653.9 -653940 2.6 TBP ZBTB10 SP1 MXD4 FEZF1 SIX5 NR2C1 MNT SMAD5 ETS1 BMS1 lnc-ZNF33B-5 ZNF32-AS2 EIF3LP2 ZNF37BP ZNF32-AS1 HNRNPF CSGALNACT2-DT ZNF239 ZNF33B
GH10J043572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 7.3 +138.0 137962 3.9 TBP SP1 SIX5 NR2C1 MNT SMAD5 ETS1 IRF2 HES1 MBD2 ZNF239 ZNF32-AS2 BMS1 RASGEF1A ZNF33B ZNF32-AS1 ZNF487 lnc-ZNF239-1 ZNF485
GH10J044244 Enhancer 1.1 Ensembl ENCODE 10 +808.5 808496 1.4 ZBTB10 FEZF1 CEBPA ZEB1 ZIC2 HOMEZ THAP11 FOXA2 ZNF511 SMAD4 lnc-C10orf142-5 piR-58929-013 ZNF32-AS2 ZNF487 lnc-CXCL12-6 CXCL12 LOC107984189
GH10J043594 Promoter/Enhancer 1.1 Ensembl ENCODE 6.7 +158.9 158941 2.2 SP1 BCL11A IRF2 IRF4 SMAD4 MAFF EBF1 SMARCA5 ZFP91 ZNF316 ENSG00000287852 ZNF487 ZNF239 piR-32380-004 ZNF485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF487 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF487

Top Transcription factor binding sites by QIAGEN in the ZNF487 gene promoter:
  • ATF-2
  • FOXO3
  • FOXO3a
  • FOXO3b
  • RORalpha1
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for ZNF487 Gene

Latest Assembly
46,344 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
46,334 bases
Plus strand

(GRCh37/hg19 by Ensembl)
59,236 bases
Plus strand

Genomic View for ZNF487 Gene

Genes around ZNF487 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF487 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF487 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF487 Gene

Proteins for ZNF487 Gene

  • Protein details for ZNF487 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative zinc finger protein 487
    Protein Accession:
    Secondary Accessions:
    • B1APH5
    • B7Z7S5

    Protein attributes for ZNF487 Gene

    448 amino acids
    Molecular mass:
    51624 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF487 Gene


neXtProt entry for ZNF487 Gene

Post-translational modifications for ZNF487 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF487 Gene

Domains & Families for ZNF487 Gene

Gene Families for ZNF487 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF487 Gene

Suggested Antigen Peptide Sequences for ZNF487 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 487 (B2REC7_HUMAN)
  • Zinc finger protein 487 (B2REC8_HUMAN)
  • KRAB domain only protein 1 (ZN487_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF487: view

Function for ZNF487 Gene

Molecular function for ZNF487 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF487 Gene

Gene Ontology (GO) - Molecular Function for ZNF487 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA, IBA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF487: view

miRNA for ZNF487 Gene

miRTarBase miRNAs that target ZNF487

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF487 Gene

Localization for ZNF487 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF487 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF487 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF487 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF487: view

Pathways & Interactions for ZNF487 Gene

PathCards logo

SuperPathways for ZNF487 Gene

No Data Available

Interacting Proteins for ZNF487 Gene

Gene Ontology (GO) - Biological Process for ZNF487 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF487: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF487 Gene

Drugs & Compounds for ZNF487 Gene

No Compound Related Data Available

Transcripts for ZNF487 Gene

mRNA/cDNA for ZNF487 Gene

1 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF487 Gene

No ASD Table

Relevant External Links for ZNF487 Gene

GeneLoc Exon Structure for

Expression for ZNF487 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF487 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF487 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for ZNF487 Gene

This gene is overexpressed in Monocytes (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF487 Gene

Protein tissue co-expression partners for ZNF487 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF487

genes like me logo Genes that share expression patterns with ZNF487: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF487 Gene

Orthologs for ZNF487 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF487 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF33B 31
  • 24 (a)
(Canis familiaris)
Mammalia -- 31
  • 16 (a)
Species where no ortholog for ZNF487 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF487 Gene

Gene Tree for ZNF487 (if available)
Gene Tree for ZNF487 (if available)
Evolutionary constrained regions (ECRs) for ZNF487: view image

Paralogs for ZNF487 Gene

genes like me logo Genes that share paralogs with ZNF487: view

Variants for ZNF487 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF487 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs11598660 - p.Arg120Ser
rs11816311 - p.Pro61Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF487 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF487 Gene

Variant ID Type Subtype PubMed ID
dgv146n67 CNV gain 20364138
esv3623045 CNV loss 21293372
nsv1043746 CNV loss 25217958
nsv1113292 CNV deletion 24896259
nsv1134001 CNV deletion 24896259
nsv1137914 CNV deletion 24896259
nsv477443 CNV novel sequence insertion 20440878
nsv831842 CNV loss 17160897

Variation tolerance for ZNF487 Gene

Gene Damage Index Score: 5.09; 69.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF487 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF487 Gene

Disorders for ZNF487 Gene

Additional Disease Information for ZNF487

No disorders were found for ZNF487 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF487 Gene

Publications for ZNF487 Gene

  1. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. (PMID: 25798074) Basei FL … Kobarg J (Proteome science 2015) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for ZNF487 Gene

Sources for ZNF487 Gene