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Aliases for ZNF487 Gene

Aliases for ZNF487 Gene

  • Zinc Finger Protein 487 2 3 5
  • Zinc Finger Protein 487, Pseudogene 2 3
  • KRAB Domain Only Protein 1 3 4
  • KRAB Domain Only 1 2 3
  • ZNF487P 3 4
  • KRBO1 3 4
  • Putative Zinc Finger Protein 487 3

External Ids for ZNF487 Gene

Previous HGNC Symbols for ZNF487 Gene

  • KRBO1
  • ZNF487P

Previous GeneCards Identifiers for ZNF487 Gene

  • GC10P043252
  • GC10P043933

Summaries for ZNF487 Gene

GeneCards Summary for ZNF487 Gene

ZNF487 (Zinc Finger Protein 487) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF684.

UniProtKB/Swiss-Prot for ZNF487 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF487 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF487 Gene

Genomics for ZNF487 Gene

GeneHancer (GH) Regulatory Elements for ZNF487 Gene

Promoters and enhancers for ZNF487 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I043435 Promoter/Enhancer 1.6 Ensembl ENCODE 550.8 0.0 -13 2.9 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF487 GC10M043434 LOC105378272 ZNF33B GC10P043432
GH10I042781 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -654.1 -654080 2.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 BMS1 GC10M042779 ZNF32-AS2 ENSG00000273008 HNRNPF EIF3LP2 ZNF32-AS1 ZNF37BP ZNF32 LOC100130881
GH10I043572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.3 +138.0 137962 3.9 CLOCK ARNT SIN3A YY1 ZNF766 CBX5 ZNF213 E2F8 ZNF143 KLF13 ZNF239 ZNF32-AS2 ZNF33B BMS1 ZNF32-AS1 ZNF487 CAP1P2
GH10I043384 Enhancer 0.8 dbSUPER 12.8 -49.7 -49655 4.6 HNRNPUL1 SMAD1 KLF17 MZF1 ZNF48 POLR2B E2F8 EGR1 SCRT2 RUNX3 PIR56810 LOC105378272 HNRNPF HNRNPA3P1 EIF3LP2 SNORD3J ZNF487 RNU7-193P RASGEF1A BMS1
GH10I044246 Enhancer 0.9 ENCODE 10 +808.9 808867 0.2 ATF1 FOXA2 FEZF1 DMAP1 ETS1 ATF7 YY2 MIER2 TSHZ1 ZNF518A ZNF32-AS2 ZNF487 ENSG00000237590 PIR37397
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF487 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF487 gene promoter:

Genomic Locations for ZNF487 Gene

Genomic Locations for ZNF487 Gene
chr10:43,436,841-43,483,179
(GRCh38/hg38)
Size:
46,339 bases
Orientation:
Plus strand
chr10:43,932,282-43,991,517
(GRCh37/hg19)

Genomic View for ZNF487 Gene

Genes around ZNF487 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF487 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF487 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF487 Gene

Proteins for ZNF487 Gene

  • Protein details for ZNF487 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1APH4-ZN487_HUMAN
    Recommended name:
    Putative zinc finger protein 487
    Protein Accession:
    B1APH4
    Secondary Accessions:
    • B1APH5
    • B7Z7S5

    Protein attributes for ZNF487 Gene

    Size:
    448 amino acids
    Molecular mass:
    51624 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15018.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO03512.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF487 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF487 Gene

Post-translational modifications for ZNF487 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF487 Gene

Domains & Families for ZNF487 Gene

Gene Families for ZNF487 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF487 Gene

Suggested Antigen Peptide Sequences for ZNF487 Gene

Graphical View of Domain Structure for InterPro Entry

B1APH4

UniProtKB/Swiss-Prot:

ZN487_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF487: view

Function for ZNF487 Gene

Molecular function for ZNF487 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF487 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF487: view

Animal Model Products

miRNA for ZNF487 Gene

miRTarBase miRNAs that target ZNF487

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF487 Gene

Localization for ZNF487 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF487 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF487 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF487 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF487: view

Pathways & Interactions for ZNF487 Gene

SuperPathways for ZNF487 Gene

No Data Available

Interacting Proteins for ZNF487 Gene

Gene Ontology (GO) - Biological Process for ZNF487 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF487: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF487 Gene

Drugs & Compounds for ZNF487 Gene

No Compound Related Data Available

Transcripts for ZNF487 Gene

mRNA/cDNA for ZNF487 Gene

(7) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF487 Gene

No ASD Table

Relevant External Links for ZNF487 Gene

GeneLoc Exon Structure for
ZNF487
ECgene alternative splicing isoforms for
ZNF487

Expression for ZNF487 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF487 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF487 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for ZNF487 Gene

This gene is overexpressed in Monocytes (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF487 Gene



Protein tissue co-expression partners for ZNF487 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF487 Gene:

ZNF487
genes like me logo Genes that share expression patterns with ZNF487: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF487 Gene

Orthologs for ZNF487 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF487 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF33B 34
  • 24 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 16 (a)
ManyToMany
Species where no ortholog for ZNF487 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF487 Gene

ENSEMBL:
Gene Tree for ZNF487 (if available)
TreeFam:
Gene Tree for ZNF487 (if available)

Paralogs for ZNF487 Gene

Paralogs for ZNF487 Gene

genes like me logo Genes that share paralogs with ZNF487: view

Variants for ZNF487 Gene

Sequence variations from dbSNP and Humsavar for ZNF487 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000049425 -- 43,451,844(+) C/T intron_variant
rs1000128833 -- 43,449,251(+) A/G intron_variant
rs1000182728 -- 43,435,424(+) G/C upstream_transcript_variant
rs1000285556 -- 43,456,849(+) G/A intron_variant
rs1000367180 -- 43,462,576(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF487 Gene

Variant ID Type Subtype PubMed ID
dgv146n67 CNV gain 20364138
esv3623045 CNV loss 21293372
nsv1043746 CNV loss 25217958
nsv1113292 CNV deletion 24896259
nsv1134001 CNV deletion 24896259
nsv1137914 CNV deletion 24896259
nsv477443 CNV novel sequence insertion 20440878
nsv831842 CNV loss 17160897

Variation tolerance for ZNF487 Gene

Gene Damage Index Score: 5.09; 69.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF487 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF487

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF487 Gene

Disorders for ZNF487 Gene

Additional Disease Information for ZNF487

No disorders were found for ZNF487 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF487 Gene

Publications for ZNF487 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58

Products for ZNF487 Gene

Sources for ZNF487 Gene

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