Aliases for ZNF486 Gene

Aliases for ZNF486 Gene

  • Zinc Finger Protein 486 2 3 4 5
  • KRAB Domain Only Protein 2 3 4
  • KRAB Domain Only 2 2 3
  • KRBO2 3 4
  • KRAB Box Only Protein 2 3
  • MGC2396 2
  • ZNF486 5

External Ids for ZNF486 Gene

Previous HGNC Symbols for ZNF486 Gene

  • KRBO2

Previous GeneCards Identifiers for ZNF486 Gene

  • GC19P020139
  • GC19P019976
  • GC19P020278

Summaries for ZNF486 Gene

GeneCards Summary for ZNF486 Gene

ZNF486 (Zinc Finger Protein 486) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF506.

UniProtKB/Swiss-Prot Summary for ZNF486 Gene

Additional gene information for ZNF486 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF486 Gene

Genomics for ZNF486 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF486 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF486 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF486

Top Transcription factor binding sites by QIAGEN in the ZNF486 gene promoter:
  • CBF(2)
  • Evi-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-Y

Genomic Locations for ZNF486 Gene

Genomic Locations for ZNF486 Gene
33,275 bases
Plus strand
33,263 bases
Plus strand

Genomic View for ZNF486 Gene

Genes around ZNF486 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF486 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF486 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF486 Gene

Proteins for ZNF486 Gene

  • Protein details for ZNF486 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 486
    Protein Accession:
    Secondary Accessions:
    • Q0VG00

    Protein attributes for ZNF486 Gene

    463 amino acids
    Molecular mass:
    53631 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH08936.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH08936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF486 Gene

Post-translational modifications for ZNF486 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF486 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF486 Gene

Domains & Families for ZNF486 Gene

Gene Families for ZNF486 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF486 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF486 Gene

GenScript: Design optimal peptide antigens:
  • ZNF486 protein (Q4G180_HUMAN)
  • KRAB domain only protein 2 (ZN486_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF486: view

Function for ZNF486 Gene

Molecular function for ZNF486 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF486 Gene

Gene Ontology (GO) - Molecular Function for ZNF486 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF486: view
genes like me logo Genes that share phenotypes with ZNF486: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF486

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF486 Gene

Localization for ZNF486 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF486 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF486 gene
Compartment Confidence
extracellular 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF486 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ZNF486: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF486 Gene

Pathways & Interactions for ZNF486 Gene

genes like me logo Genes that share pathways with ZNF486: view

Pathways by source for ZNF486 Gene

2 Reactome pathways for ZNF486 Gene
1 KEGG pathway for ZNF486 Gene

Interacting Proteins for ZNF486 Gene

Gene Ontology (GO) - Biological Process for ZNF486 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF486: view

No data available for SIGNOR curated interactions for ZNF486 Gene

Drugs & Compounds for ZNF486 Gene

No Compound Related Data Available

Transcripts for ZNF486 Gene

mRNA/cDNA for ZNF486 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF486

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF486 Gene

No ASD Table

Relevant External Links for ZNF486 Gene

GeneLoc Exon Structure for

Expression for ZNF486 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF486 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF486 Gene

This gene is overexpressed in Thyroid (x8.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF486

SOURCE GeneReport for Unigene cluster for ZNF486 Gene:


Evidence on tissue expression from TISSUES for ZNF486 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with ZNF486: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF486 Gene

Orthologs for ZNF486 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF486 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF728 30
  • 99.14 (n)
ZNF486 31
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
-- 31
  • 30 (a)
(Bos Taurus)
Mammalia -- 31
  • 43 (a)
(Mus musculus)
Mammalia Zfp386 31
  • 31 (a)
(Canis familiaris)
Mammalia -- 31
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
-- 31
  • 33 (a)
-- 31
  • 31 (a)
-- 31
  • 27 (a)
-- 31
  • 25 (a)
-- 31
  • 25 (a)
-- 31
  • 24 (a)
-- 31
  • 24 (a)
Species where no ortholog for ZNF486 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF486 Gene

Gene Tree for ZNF486 (if available)
Gene Tree for ZNF486 (if available)
Evolutionary constrained regions (ECRs) for ZNF486: view image

Paralogs for ZNF486 Gene

Paralogs for ZNF486 Gene

(509) SIMAP similar genes for ZNF486 Gene using alignment to 3 proteins:

  • ZN486_HUMAN
  • Q4G180_HUMAN
genes like me logo Genes that share paralogs with ZNF486: view

Variants for ZNF486 Gene

Additional dbSNP identifiers (rs#s) for ZNF486 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF486 Gene

Variant ID Type Subtype PubMed ID
dgv3456n100 CNV gain 25217958
dgv3457n100 CNV gain 25217958
dgv3458n100 CNV loss 25217958
dgv3459n100 CNV loss 25217958
dgv509e201 CNV deletion 23290073
dgv6303n54 CNV loss 21841781
dgv630e199 CNV deletion 23128226
esv2663395 CNV deletion 23128226
esv2718296 CNV deletion 23290073
esv2718305 CNV deletion 23290073
esv2758748 CNV gain 17122850
esv34357 CNV gain 17911159
esv3574330 CNV gain 25503493
esv3583276 CNV loss 25503493
esv3643874 CNV loss 21293372
esv3643875 CNV loss 21293372
esv3643876 CNV loss 21293372
nsv1059188 CNV loss 25217958
nsv1061846 CNV loss 25217958
nsv1061915 CNV loss 25217958
nsv1131412 CNV deletion 24896259
nsv519535 CNV gain 19592680
nsv520325 CNV gain 19592680
nsv578804 CNV gain 21841781
nsv578805 CNV gain 21841781
nsv578806 CNV loss 21841781
nsv578807 CNV loss 21841781
nsv817820 CNV gain 17921354
nsv963020 CNV duplication 23825009

Variation tolerance for ZNF486 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF486 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF486 Gene

Disorders for ZNF486 Gene

No disorders were found for ZNF486 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF486 Gene

Publications for ZNF486 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for ZNF486 Gene

  • Signalway Proteins for ZNF486

Sources for ZNF486 Gene