Aliases for ZNF485 Gene

Aliases for ZNF485 Gene

  • Zinc Finger Protein 485 2 3 4 5
  • Zinc Finger Protein 93 (Zinc Finger Protein HTF34) 3

External Ids for ZNF485 Gene

Previous GeneCards Identifiers for ZNF485 Gene

  • GC10P043256
  • GC10P043421
  • GC10P044101
  • GC10P040628

Summaries for ZNF485 Gene

GeneCards Summary for ZNF485 Gene

ZNF485 (Zinc Finger Protein 485) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF808.

UniProtKB/Swiss-Prot Summary for ZNF485 Gene

Additional gene information for ZNF485 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF485 Gene

Genomics for ZNF485 Gene

GeneHancer (GH) Regulatory Elements for ZNF485 Gene

Promoters and enhancers for ZNF485 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J043605 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.3 294 1.8 ZBTB40 ZNF217 SIN3A MYC USF1 POLR2G PHF8 SIX5 ZFX ZIC2 CAP1P2 ZNF485 ZNF32 lnc-ZNF32-5
GH10J043604 Enhancer 0.3 FANTOM5 500.7 -1.2 -1234 0.5 CAP1P2 ZNF485 ZNF239 ENSG00000229116 CSGALNACT2 piR-38580-032
GH10J043613 Enhancer 0.4 Ensembl ENCODE 0.4 +7.4 7422 1.3 FOS lnc-ZNF32-5 ZNF32 ZNF32-AS2 ZNF239 ENSG00000229116 ZNF485 piR-40136
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF485 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF485

Top Transcription factor binding sites by QIAGEN in the ZNF485 gene promoter:
  • Cart-1
  • GATA-1
  • GATA-2
  • GATA-3
  • Ik-2
  • LCR-F1
  • Nkx2-2
  • p300
  • POU3F2
  • YY1

Genomic Locations for ZNF485 Gene

Genomic Locations for ZNF485 Gene
chr10:43,606,407-43,617,904
(GRCh38/hg38)
Size:
11,498 bases
Orientation:
Plus strand
chr10:44,101,855-44,113,352
(GRCh37/hg19)
Size:
11,498 bases
Orientation:
Plus strand

Genomic View for ZNF485 Gene

Genes around ZNF485 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF485 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF485 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF485 Gene

Proteins for ZNF485 Gene

  • Protein details for ZNF485 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCK3-ZN485_HUMAN
    Recommended name:
    Zinc finger protein 485
    Protein Accession:
    Q8NCK3
    Secondary Accessions:
    • B4DSE6
    • Q96CL0

    Protein attributes for ZNF485 Gene

    Size:
    441 amino acids
    Molecular mass:
    50280 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14161.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF485 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF485 Gene

Post-translational modifications for ZNF485 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF485 Gene

No data available for DME Specific Peptides for ZNF485 Gene

Domains & Families for ZNF485 Gene

Gene Families for ZNF485 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF485 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF485 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57580, highly similar to Zinc finger protein 485 (B4DSE6_HUMAN)
  • Zinc finger protein 485 (ZN485_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCK3

UniProtKB/Swiss-Prot:

ZN485_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF485: view

Function for ZNF485 Gene

Molecular function for ZNF485 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF485 Gene

Gene Ontology (GO) - Molecular Function for ZNF485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF485: view
genes like me logo Genes that share phenotypes with ZNF485: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF485 Gene

Localization for ZNF485 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF485 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF485 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF485: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF485 Gene

Pathways & Interactions for ZNF485 Gene

PathCards logo

SuperPathways for ZNF485 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF485: view

Pathways by source for ZNF485 Gene

2 Reactome pathways for ZNF485 Gene

Interacting Proteins for ZNF485 Gene

;

Gene Ontology (GO) - Biological Process for ZNF485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF485: view

No data available for SIGNOR curated interactions for ZNF485 Gene

Drugs & Compounds for ZNF485 Gene

No Compound Related Data Available

Transcripts for ZNF485 Gene

mRNA/cDNA for ZNF485 Gene

5 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF485 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for ZNF485 Gene

GeneLoc Exon Structure for
ZNF485

Expression for ZNF485 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF485 Gene

Protein differential expression in normal tissues from HIPED for ZNF485 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF485 Gene



Protein tissue co-expression partners for ZNF485 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF485

SOURCE GeneReport for Unigene cluster for ZNF485 Gene:

Hs.147440

Evidence on tissue expression from TISSUES for ZNF485 Gene

  • Nervous system(4.3)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZNF485: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF485 Gene

Orthologs for ZNF485 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF485 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF485 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF485 31 30
  • 88.31 (n)
OneToOne
Species where no ortholog for ZNF485 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF485 Gene

ENSEMBL:
Gene Tree for ZNF485 (if available)
TreeFam:
Gene Tree for ZNF485 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF485: view image

Paralogs for ZNF485 Gene

Paralogs for ZNF485 Gene

(553) SIMAP similar genes for ZNF485 Gene using alignment to 3 proteins:

  • ZN485_HUMAN
  • B4DSE6_HUMAN
  • C9JV60_HUMAN

Pseudogenes.org Pseudogenes for ZNF485 Gene

genes like me logo Genes that share paralogs with ZNF485: view

Variants for ZNF485 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF485 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs12354886 - p.Ala252Thr

Additional dbSNP identifiers (rs#s) for ZNF485 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF485 Gene

Variant ID Type Subtype PubMed ID
nsv522992 CNV loss 19592680
nsv947897 CNV duplication 23825009

Variation tolerance for ZNF485 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF485 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF485

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF485 Gene

Disorders for ZNF485 Gene

Additional Disease Information for ZNF485

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF485 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF485 Gene

Publications for ZNF485 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54

Products for ZNF485 Gene

Sources for ZNF485 Gene