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Aliases for ZNF484 Gene

Aliases for ZNF484 Gene

  • Zinc Finger Protein 484 2 3 5
  • KRAB Box Containing C2H2 Type Zinc Finger BA526D8.4 3
  • BA526D8.4 3

External Ids for ZNF484 Gene

Previous GeneCards Identifiers for ZNF484 Gene

  • GC09M092687
  • GC09M094648
  • GC09M095609
  • GC09M065285

Summaries for ZNF484 Gene

GeneCards Summary for ZNF484 Gene

ZNF484 (Zinc Finger Protein 484) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF81.

UniProtKB/Swiss-Prot for ZNF484 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF484 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF484 Gene

Genomics for ZNF484 Gene

GeneHancer (GH) Regulatory Elements for ZNF484 Gene

Promoters and enhancers for ZNF484 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I092877 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 214 1.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF484 FGD3 CENPP LOC100419515 ANKRD19P
GH09I092868 Promoter 0.5 EPDnew 550.4 +10.0 9972 0.1 ZNF484 FGD3 LOC100419515 ANKRD19P
GH09I092323 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.8 +552.6 552627 3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 NOL8 CENPP MTND4P15 IARS LINC00475 ZNF484 SPTLC1 LOC100128076 MTCO3P29
GH09I093125 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -252.5 -252514 10.1 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 NINJ1 CARD19 ZNF484 LOC101927993 SUSD3 PHF2 IPPK
GH09I093183 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 13.1 -308.4 -308385 5 RING1 MXI1 PKNOX1 RB1 ZNF449 SIN3A ZNF335 ZNF121 ZFHX2 GLIS2 WNK2 ZNF484 PHF2 ENSG00000203364 CARD19 PIR56775
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF484 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF484 gene promoter:

Genomic Locations for ZNF484 Gene

Genomic Locations for ZNF484 Gene
chr9:92,842,573-92,878,058
(GRCh38/hg38)
Size:
35,486 bases
Orientation:
Minus strand
chr9:95,607,874-95,640,304
(GRCh37/hg19)

Genomic View for ZNF484 Gene

Genes around ZNF484 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF484 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF484 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF484 Gene

Proteins for ZNF484 Gene

  • Protein details for ZNF484 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVG2-ZN484_HUMAN
    Recommended name:
    Zinc finger protein 484
    Protein Accession:
    Q5JVG2
    Secondary Accessions:
    • B1AL89
    • B4DRI2

    Protein attributes for ZNF484 Gene

    Size:
    852 amino acids
    Molecular mass:
    98221 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF484 Gene

    Alternative splice isoforms for ZNF484 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF484 Gene

Post-translational modifications for ZNF484 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF484 Gene

Domains & Families for ZNF484 Gene

Gene Families for ZNF484 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

Q5JVG2

UniProtKB/Swiss-Prot:

ZN484_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF484: view

Function for ZNF484 Gene

Molecular function for ZNF484 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF484: view
genes like me logo Genes that share phenotypes with ZNF484: view

miRNA for ZNF484 Gene

miRTarBase miRNAs that target ZNF484

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF484 Gene

Localization for ZNF484 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF484 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF484 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF484: view

Pathways & Interactions for ZNF484 Gene

SuperPathways for ZNF484 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF484: view

Pathways by source for ZNF484 Gene

2 Reactome pathways for ZNF484 Gene

Interacting Proteins for ZNF484 Gene

Gene Ontology (GO) - Biological Process for ZNF484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF484: view

No data available for SIGNOR curated interactions for ZNF484 Gene

Drugs & Compounds for ZNF484 Gene

No Compound Related Data Available

Transcripts for ZNF484 Gene

Unigene Clusters for ZNF484 Gene

Zinc finger protein 484:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF484 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -

Relevant External Links for ZNF484 Gene

GeneLoc Exon Structure for
ZNF484
ECgene alternative splicing isoforms for
ZNF484

Expression for ZNF484 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF484 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF484 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF484 Gene:

ZNF484

SOURCE GeneReport for Unigene cluster for ZNF484 Gene:

Hs.668378

Evidence on tissue expression from TISSUES for ZNF484 Gene

  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ZNF484: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF484 Gene

Orthologs for ZNF484 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF484 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF484 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia ZNF484 33
  • 86.5 (n)
cow
(Bos Taurus)
Mammalia ZNF484 33
  • 85.46 (n)
-- 34
  • 56 (a)
ManyToMany
Species where no ortholog for ZNF484 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF484 Gene

ENSEMBL:
Gene Tree for ZNF484 (if available)
TreeFam:
Gene Tree for ZNF484 (if available)

Paralogs for ZNF484 Gene

Paralogs for ZNF484 Gene

(401) SIMAP similar genes for ZNF484 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF484 Gene

genes like me logo Genes that share paralogs with ZNF484: view

Variants for ZNF484 Gene

Sequence variations from dbSNP and Humsavar for ZNF484 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000092652 -- 92,849,799(-) TCTTT/T intron_variant
rs1000152821 -- 92,843,244(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000183374 -- 92,843,026(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000347631 -- 92,877,720(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000446508 -- 92,850,095(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF484 Gene

Variant ID Type Subtype PubMed ID
esv1653300 CNV deletion 17803354
esv2468145 CNV deletion 19546169
esv2671782 CNV deletion 23128226
esv2738775 CNV deletion 23290073
esv3407276 CNV insertion 20981092
esv3545131 CNV deletion 23714750
esv3576684 CNV gain 25503493
nsv831654 CNV gain 17160897
nsv972781 CNV duplication 23825009

Variation tolerance for ZNF484 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF484 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF484

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF484 Gene

Disorders for ZNF484 Gene

Additional Disease Information for ZNF484

No disorders were found for ZNF484 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF484 Gene

Publications for ZNF484 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58

Products for ZNF484 Gene

Sources for ZNF484 Gene

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