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Aliases for ZNF484 Gene

Aliases for ZNF484 Gene

  • Zinc Finger Protein 484 2 3 4 5
  • KRAB Box Containing C2H2 Type Zinc Finger BA526D8.4 3
  • BA526D8.4 3

External Ids for ZNF484 Gene

Previous GeneCards Identifiers for ZNF484 Gene

  • GC09M092687
  • GC09M094648
  • GC09M095609
  • GC09M065285

Summaries for ZNF484 Gene

GeneCards Summary for ZNF484 Gene

ZNF484 (Zinc Finger Protein 484) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF41.

UniProtKB/Swiss-Prot for ZNF484 Gene

Additional gene information for ZNF484 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF484 Gene

Genomics for ZNF484 Gene

GeneHancer (GH) Regulatory Elements for ZNF484 Gene

Promoters and enhancers for ZNF484 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J092877 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.5 514 2.3 ZFX ELF3 MNT SIX5 ZNF148 NKRF MLLT1 GTF2F1 CSDE1 NFIB ZNF484 FGD3 CENPP LOC100419515 ANKRD19P
GH09J092323 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.8 +552.4 552380 3.4 SP1 CC2D1A ZFX ELF3 MNT SIX5 CBFA2T2 NKRF POLR2A MLLT1 NOL8 CENPP MTND4P15 IARS LINC00475 ZNF484 ENSG00000234537 MTCO3P29
GH09J093090 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 -217.6 -217611 9.5 HDGF SP1 ZFX ELF3 CBFA2T2 NKRF POLR2A ZNF687 JUND SP7 CARD19 LOC101927993 ENSG00000223446 PHF2 LINC00475 NOL8 NINJ1 IARS ZNF484 SUSD3
GH09J092759 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +114.9 114910 6.7 HDGF SP1 ZFX CTCF ELF3 MNT SIX5 NKRF POLR2A GTF2F1 BICD2 PHF2 CENPP ZNF484 LINC00475 IPPK ECM2 GC09P092689
GH09J092946 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.3 -70.2 -70243 3 ZNF473 CDC5L HDGF CREB1 GLIS2 ZBTB8A YBX1 RFX1 ZIC2 ZSCAN4 FGD3 NOL8 MTND4P15 IARS PHF2 FAM120A ZNF484 LINC00475 SUSD3 MTCO3P29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF484 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF484 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • POU3F1
  • RORalpha2

Genomic Locations for ZNF484 Gene

Genomic Locations for ZNF484 Gene
chr9:92,842,573-92,878,058
(GRCh38/hg38)
Size:
35,486 bases
Orientation:
Minus strand
chr9:95,607,874-95,640,304
(GRCh37/hg19)
Size:
32,431 bases
Orientation:
Minus strand

Genomic View for ZNF484 Gene

Genes around ZNF484 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF484 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF484 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF484 Gene

Proteins for ZNF484 Gene

  • Protein details for ZNF484 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVG2-ZN484_HUMAN
    Recommended name:
    Zinc finger protein 484
    Protein Accession:
    Q5JVG2
    Secondary Accessions:
    • B1AL89
    • B4DRI2

    Protein attributes for ZNF484 Gene

    Size:
    852 amino acids
    Molecular mass:
    98221 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF484 Gene

    Alternative splice isoforms for ZNF484 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF484 Gene

Post-translational modifications for ZNF484 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF484 Gene

Domains & Families for ZNF484 Gene

Gene Families for ZNF484 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF484 Gene

Suggested Antigen Peptide Sequences for ZNF484 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33884 fis, clone CTONG2007293, highly similar to Zinc finger protein 484 (B1AL89_HUMAN)
  • cDNA FLJ56482, highly similar to Zinc finger protein 484 (B4DRI2_HUMAN)
  • Zinc finger protein 484 (ZN484_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5JVG2

UniProtKB/Swiss-Prot:

ZN484_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF484: view

Function for ZNF484 Gene

Molecular function for ZNF484 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF484 Gene

Gene Ontology (GO) - Molecular Function for ZNF484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF484: view
genes like me logo Genes that share phenotypes with ZNF484: view

Animal Model Products

CRISPR Products

miRNA for ZNF484 Gene

miRTarBase miRNAs that target ZNF484

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF484 - Now 50% OFF >
  • * ZNF484 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF484 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF484 Gene

Localization for ZNF484 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF484 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF484 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF484: view

Pathways & Interactions for ZNF484 Gene

genes like me logo Genes that share pathways with ZNF484: view

Pathways by source for ZNF484 Gene

2 Reactome pathways for ZNF484 Gene
1 KEGG pathway for ZNF484 Gene

Interacting Proteins for ZNF484 Gene

Gene Ontology (GO) - Biological Process for ZNF484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF484: view

No data available for SIGNOR curated interactions for ZNF484 Gene

Drugs & Compounds for ZNF484 Gene

No Compound Related Data Available

Transcripts for ZNF484 Gene

Unigene Clusters for ZNF484 Gene

Zinc finger protein 484:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF484 - Now 50% OFF >
  • * ZNF484 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF484 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF484 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -

Relevant External Links for ZNF484 Gene

GeneLoc Exon Structure for
ZNF484
ECgene alternative splicing isoforms for
ZNF484

Expression for ZNF484 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF484 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF484 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF484 Gene:

ZNF484

SOURCE GeneReport for Unigene cluster for ZNF484 Gene:

Hs.668378

Evidence on tissue expression from TISSUES for ZNF484 Gene

  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ZNF484: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF484 Gene

Orthologs for ZNF484 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF484 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF484 35 34
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF484 34
  • 86.5 (n)
cow
(Bos Taurus)
Mammalia ZNF484 34
  • 85.46 (n)
-- 35
  • 56 (a)
ManyToMany
Species where no ortholog for ZNF484 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF484 Gene

ENSEMBL:
Gene Tree for ZNF484 (if available)
TreeFam:
Gene Tree for ZNF484 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF484: view image

Paralogs for ZNF484 Gene

Paralogs for ZNF484 Gene

(401) SIMAP similar genes for ZNF484 Gene using alignment to 1 proteins:

  • ZN484_HUMAN

Pseudogenes.org Pseudogenes for ZNF484 Gene

genes like me logo Genes that share paralogs with ZNF484: view

Variants for ZNF484 Gene

Sequence variations from dbSNP and Humsavar for ZNF484 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000092652 -- 92,849,799(-) TCTTT/T intron_variant
rs1000347631 -- 92,877,720(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000446508 -- 92,850,095(-) C/T intron_variant
rs1000448579 -- 92,871,564(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000643068 -- 92,878,977(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF484 Gene

Variant ID Type Subtype PubMed ID
esv1653300 CNV deletion 17803354
esv2468145 CNV deletion 19546169
esv2671782 CNV deletion 23128226
esv2738775 CNV deletion 23290073
esv3407276 CNV insertion 20981092
esv3545131 CNV deletion 23714750
esv3576684 CNV gain 25503493
nsv831654 CNV gain 17160897
nsv972781 CNV duplication 23825009

Variation tolerance for ZNF484 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF484 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF484

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF484 Gene

Disorders for ZNF484 Gene

Additional Disease Information for ZNF484

No disorders were found for ZNF484 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF484 Gene

Publications for ZNF484 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF484 Gene

Sources for ZNF484 Gene

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