Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF480 Gene

Aliases for ZNF480 Gene

  • Zinc Finger Protein 480 2 3 5

External Ids for ZNF480 Gene

Previous GeneCards Identifiers for ZNF480 Gene

  • GC19P057493
  • GC19P057494
  • GC19P052800
  • GC19P049130

Summaries for ZNF480 Gene

GeneCards Summary for ZNF480 Gene

ZNF480 (Zinc Finger Protein 480) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot for ZNF480 Gene

  • Involved in transcriptional regulation as an activator.

Additional gene information for ZNF480 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF480 Gene

Genomics for ZNF480 Gene

GeneHancer (GH) Regulatory Elements for ZNF480 Gene

Promoters and enhancers for ZNF480 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052296 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 555.7 +0.2 226 2.1 HDAC1 ELF3 ARID4B SIN3A DMAP1 ZBTB40 KLF5 ETS1 ZNF335 POLR2B ZNF480 ENSG00000269102
GH19I052300 Promoter 0.5 EPDnew 550.8 +3.1 3149 0.1 ZNF480 ENSG00000269102 ZNF610
GH19I052314 Promoter 0.5 EPDnew 550.4 +17.3 17309 0.1 ZNF480 ENSG00000269102 ZNF610 ENSG00000269535
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 43.8 -606.7 -606678 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I051338 Promoter/Enhancer 1.6 Ensembl ENCODE 20.8 -957.4 -957384 2.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF416 ENSG00000267905 ZNF841 ZNF577 POLD1 ZNF616 ZNF175 ZNF480 ZNF766 ZNF350 ZNF836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF480 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF480 gene promoter:

Genomic Locations for ZNF480 Gene

Genomic Locations for ZNF480 Gene
chr19:52,297,169-52,325,927
(GRCh38/hg38)
Size:
28,759 bases
Orientation:
Plus strand
chr19:52,800,426-52,829,175
(GRCh37/hg19)

Genomic View for ZNF480 Gene

Genes around ZNF480 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF480 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF480 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF480 Gene

Proteins for ZNF480 Gene

  • Protein details for ZNF480 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV37-ZN480_HUMAN
    Recommended name:
    Zinc finger protein 480
    Protein Accession:
    Q8WV37
    Secondary Accessions:
    • Q5JPG9
    • Q6P0Q4
    • Q8N1M5

    Protein attributes for ZNF480 Gene

    Size:
    535 amino acids
    Molecular mass:
    61708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF480 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF480 Gene

Post-translational modifications for ZNF480 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF480 Gene

Domains & Families for ZNF480 Gene

Gene Families for ZNF480 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF480 Gene

Suggested Antigen Peptide Sequences for ZNF480 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV37

UniProtKB/Swiss-Prot:

ZN480_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF480: view

Function for ZNF480 Gene

Molecular function for ZNF480 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation as an activator.

Gene Ontology (GO) - Molecular Function for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF480: view
genes like me logo Genes that share phenotypes with ZNF480: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF480 Gene

Localization for ZNF480 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF480 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF480 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF480: view

Pathways & Interactions for ZNF480 Gene

SuperPathways for ZNF480 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF480: view

Pathways by source for ZNF480 Gene

2 Reactome pathways for ZNF480 Gene

Interacting Proteins for ZNF480 Gene

Gene Ontology (GO) - Biological Process for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF480: view

No data available for SIGNOR curated interactions for ZNF480 Gene

Drugs & Compounds for ZNF480 Gene

No Compound Related Data Available

Transcripts for ZNF480 Gene

Unigene Clusters for ZNF480 Gene

Zinc finger protein 480:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF480 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: -

Relevant External Links for ZNF480 Gene

GeneLoc Exon Structure for
ZNF480
ECgene alternative splicing isoforms for
ZNF480

Expression for ZNF480 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF480 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF480 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF480 Gene:

ZNF480

SOURCE GeneReport for Unigene cluster for ZNF480 Gene:

Hs.729317

mRNA Expression by UniProt/SwissProt for ZNF480 Gene:

Q8WV37-ZN480_HUMAN
Tissue specificity: Expressed in fetal heart, heart, skeletal muscle, pancreas and placenta.

Evidence on tissue expression from TISSUES for ZNF480 Gene

  • Nervous system(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF480: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF480 Gene

Orthologs for ZNF480 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF480 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF480 33
  • 98.88 (n)
-- 34
  • 91 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ZNF415 33
  • 64.04 (n)
-- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF480 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF480 Gene

ENSEMBL:
Gene Tree for ZNF480 (if available)
TreeFam:
Gene Tree for ZNF480 (if available)

Paralogs for ZNF480 Gene

(568) SIMAP similar genes for ZNF480 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF480: view

Variants for ZNF480 Gene

Sequence variations from dbSNP and Humsavar for ZNF480 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_035584 A colorectal cancer sample p.His361Gln
rs3217319 benign, not specified 52,300,417(+) TGTGTG/TGTG 5_prime_UTR_variant, coding_sequence_variant, inframe_indel, stop_gained
rs1000004859 -- 52,313,983(+) A/C intron_variant
rs1000078366 -- 52,312,479(+) G/T intron_variant
rs1000101457 -- 52,320,071(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF480 Gene

Variant ID Type Subtype PubMed ID
nsv833873 CNV gain 17160897
nsv580008 CNV loss 21841781
nsv475700 CNV novel sequence insertion 20440878
nsv458742 CNV loss 19166990
nsv1140251 OTHER inversion 24896259
esv3644688 CNV loss 21293372
esv27010 CNV loss 19812545

Variation tolerance for ZNF480 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF480 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF480

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF480 Gene

Disorders for ZNF480 Gene

Additional Disease Information for ZNF480

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF480 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF480 Gene

Publications for ZNF480 Gene

  1. A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE. (PMID: 15219843) Yi Z … Wu X (Biochemical and biophysical research communications 2004) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF480 Gene

Sources for ZNF480 Gene

Content
Loading form....