Aliases for ZNF480 Gene

Aliases for ZNF480 Gene

  • Zinc Finger Protein 480 2 3 4 5
  • MGC32104 2
  • ZNF480 5

External Ids for ZNF480 Gene

Previous GeneCards Identifiers for ZNF480 Gene

  • GC19P057493
  • GC19P057494
  • GC19P052800
  • GC19P049130

Summaries for ZNF480 Gene

GeneCards Summary for ZNF480 Gene

ZNF480 (Zinc Finger Protein 480) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF610.

UniProtKB/Swiss-Prot Summary for ZNF480 Gene

Additional gene information for ZNF480 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF480 Gene

Genomics for ZNF480 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF480 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF480 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF480

Top Transcription factor binding sites by QIAGEN in the ZNF480 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • ATF6
  • c-Jun
  • Chx10
  • Ik-1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZNF480 Gene

Genomic Locations for ZNF480 Gene
chr19:52,297,169-52,325,927
(GRCh38/hg38)
Size:
28,759 bases
Orientation:
Plus strand
chr19:52,800,426-52,829,175
(GRCh37/hg19)
Size:
28,750 bases
Orientation:
Plus strand

Genomic View for ZNF480 Gene

Genes around ZNF480 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF480 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF480 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF480 Gene

Proteins for ZNF480 Gene

  • Protein details for ZNF480 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV37-ZN480_HUMAN
    Recommended name:
    Zinc finger protein 480
    Protein Accession:
    Q8WV37
    Secondary Accessions:
    • Q5JPG9
    • Q6P0Q4
    • Q8N1M5

    Protein attributes for ZNF480 Gene

    Size:
    535 amino acids
    Molecular mass:
    61708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF480 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF480 Gene

Post-translational modifications for ZNF480 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF480 Gene

Domains & Families for ZNF480 Gene

Gene Families for ZNF480 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF480 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF480 Gene

GenScript: Design optimal peptide antigens:
  • ZNF480 protein (Q05DL7_HUMAN)
  • ZNF480 protein (Q7Z2X8_HUMAN)
  • Zinc finger protein 480 (ZN480_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WV37

UniProtKB/Swiss-Prot:

ZN480_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF480: view

Function for ZNF480 Gene

Molecular function for ZNF480 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation as an activator.

Phenotypes From GWAS Catalog for ZNF480 Gene

Gene Ontology (GO) - Molecular Function for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF480: view
genes like me logo Genes that share phenotypes with ZNF480: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF480

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF480 Gene

Localization for ZNF480 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF480 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF480 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF480: view

Pathways & Interactions for ZNF480 Gene

genes like me logo Genes that share pathways with ZNF480: view

Pathways by source for ZNF480 Gene

2 Reactome pathways for ZNF480 Gene
1 KEGG pathway for ZNF480 Gene

Gene Ontology (GO) - Biological Process for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF480: view

No data available for SIGNOR curated interactions for ZNF480 Gene

Drugs & Compounds for ZNF480 Gene

No Compound Related Data Available

Transcripts for ZNF480 Gene

mRNA/cDNA for ZNF480 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF480

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF480 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: -

Relevant External Links for ZNF480 Gene

GeneLoc Exon Structure for
ZNF480

Expression for ZNF480 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF480 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF480 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF480

SOURCE GeneReport for Unigene cluster for ZNF480 Gene:

Hs.729317

mRNA Expression by UniProt/SwissProt for ZNF480 Gene:

Q8WV37-ZN480_HUMAN
Tissue specificity: Expressed in fetal heart, heart, skeletal muscle, pancreas and placenta.

Evidence on tissue expression from TISSUES for ZNF480 Gene

  • Nervous system(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF480: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF480 Gene

Orthologs for ZNF480 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF480 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF480 30
  • 98.88 (n)
-- 31
  • 91 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia ZNF415 30
  • 64.04 (n)
-- 31
  • 41 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF480 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF480 Gene

ENSEMBL:
Gene Tree for ZNF480 (if available)
TreeFam:
Gene Tree for ZNF480 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF480: view image

Paralogs for ZNF480 Gene

(568) SIMAP similar genes for ZNF480 Gene using alignment to 6 proteins:

  • ZN480_HUMAN
  • C9IZQ0_HUMAN
  • F8WEZ9_HUMAN
  • M0R367_HUMAN
  • Q05DL7_HUMAN
  • Q7Z2X8_HUMAN
genes like me logo Genes that share paralogs with ZNF480: view

Variants for ZNF480 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF480 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs3217319 Benign: not specified 52,300,416(+) CTG/C NONSENSE,FIVE_PRIME_UTR_VARIANT
VAR_035584 A colorectal cancer sample p.His361Gln
rs13343641 - p.Pro177Ser

Additional dbSNP identifiers (rs#s) for ZNF480 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF480 Gene

Variant ID Type Subtype PubMed ID
esv27010 CNV loss 19812545
esv3644688 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv458742 CNV loss 19166990
nsv475700 CNV novel sequence insertion 20440878
nsv580008 CNV loss 21841781
nsv833873 CNV gain 17160897

Variation tolerance for ZNF480 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF480 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF480

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF480 Gene

Disorders for ZNF480 Gene

Additional Disease Information for ZNF480

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF480 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF480 Gene

Publications for ZNF480 Gene

  1. A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE. (PMID: 15219843) Yi Z … Wu X (Biochemical and biophysical research communications 2004) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF480 Gene

Sources for ZNF480 Gene