Aliases for ZNF48 Gene
External Ids for ZNF48 Gene
- HGNC: 13114
- Entrez Gene: 197407
- Ensembl: ENSG00000180035
- UniProtKB: Q96MX3
Previous HGNC Symbols for ZNF48 Gene
- ZNF553
Previous GeneCards Identifiers for ZNF48 Gene
- GC16U990064
- GC16P030315
- GC16P030406
- GC16P027968
- GC16P030389
Summaries for ZNF48 Gene
GeneCards Summary for ZNF48 Gene
ZNF48 (Zinc Finger Protein 48) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for ZNF48 Gene
-
May be involved in transcriptional regulation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF48 Gene
Genomics for ZNF48 Gene
GeneHancer (GH) Regulatory Elements for ZNF48 Gene
Promoters and enhancers for ZNF48 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF48 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZNF48 gene promoter:
-
- Meis-1b
- Meis-1
- HOXA9B
- HOXA9
- p53
- Elk-1
- AREB6
- Bach1
- AML1a
- Tal-1beta
Regulatory Element Products
Genomic Locations for ZNF48 Gene
Genomic Locations for ZNF48 Gene
- chr16:30,378,106-30,400,108
- (GRCh38/hg38)
- Size:
- 22,003 bases
- Orientation:
- Plus strand
- chr16:30,389,427-30,411,429
- (GRCh37/hg19)
- Size:
- 22,003 bases
- Orientation:
- Plus strand
Genomic View for ZNF48 Gene
Genes around ZNF48 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
- 16p11.2 by Ensembl
ZNF48 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF48 Gene
Proteins for ZNF48 Gene
-
Protein details for ZNF48 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96MX3-ZNF48_HUMAN
- Recommended name:
- Zinc finger protein 48
- Protein Accession:
- Q96MX3
- Q15920
- Q4G0R3
- Q69YP3
- Q96IL9
Protein attributes for ZNF48 Gene
- Size:
- 618 amino acids
- Molecular mass:
- 67820 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA61316.1; Type=Frameshift; Positions=168; Evidence={ECO:0000305};
Protein Expression for ZNF48 Gene
Post-translational modifications for ZNF48 Gene
Other Protein References for ZNF48 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF48
- Novus Biologicals Antibodies for ZNF48
- Invitrogen Antibodies for ZNF48
- antibodies-online: Search results for 4 available ZNF48 Antibodies ranked by validation data
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-
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-
Boster Bio Antibodies for ZNF48
Protein Products
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- antibodies-online: Search results for 1 available ZNF48 Proteins ranked by validation data
- Compare Top ZNF48 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ZNF48
Assay Products
No data available for DME Specific Peptides for ZNF48 Gene
Domains & Families for ZNF48 Gene
Gene Families for ZNF48 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF48 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF48 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96MX3- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF48 Gene
Molecular function for ZNF48 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
- GENATLAS Biochemistry:
- zinc finger protein 48 (C2H2 type,Kruppel-like)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF48 Gene
- MGI mutant phenotypes for ZNF48:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZNF48:
-
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased shRNA abundance (Z-score < -2)
- Increased Nanog expression
- Decreased viability
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- Increased Sindbis virus (SINV) infection
- Increased transferrin (TF) endocytosis
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF48
-
CRISPR Products
-
OriGene CRISPR knockouts for ZNF48
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- Applied Biological Materials CRISPR for ZNF48
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF48
- GenScript: Design CRISPR guide RNA sequences for ZNF48
miRNA for ZNF48 Gene
- miRTarBase miRNAs that target ZNF48
-
- hsa-mir-1-3p (MIRT023873)
- hsa-mir-766-3p (MIRT039013)
- hsa-mir-484 (MIRT042355)
- hsa-mir-5089-5p (MIRT627158)
- hsa-mir-7151-3p (MIRT627159)
- hsa-mir-5095 (MIRT627160)
- hsa-mir-3177-5p (MIRT627161)
- hsa-mir-3650 (MIRT627162)
- hsa-mir-5589-5p (MIRT627163)
- hsa-mir-4731-5p (MIRT627164)
- hsa-mir-6506-5p (MIRT627165)
- hsa-mir-619-5p (MIRT627166)
- hsa-mir-3692-5p (MIRT627167)
- hsa-mir-3934-5p (MIRT627168)
- hsa-mir-6504-3p (MIRT627169)
- hsa-mir-552-3p (MIRT627170)
- hsa-mir-548av-3p (MIRT627171)
- hsa-mir-877-3p (MIRT651095)
- hsa-mir-4659b-3p (MIRT651096)
- hsa-mir-4659a-3p (MIRT651097)
- hsa-mir-6875-3p (MIRT651098)
- hsa-mir-5006-3p (MIRT651099)
- hsa-mir-629-3p (MIRT651100)
- hsa-mir-4755-5p (MIRT651101)
- hsa-mir-6867-3p (MIRT651102)
- hsa-mir-4713-5p (MIRT651103)
- hsa-mir-6868-3p (MIRT651104)
- hsa-mir-6749-3p (MIRT651105)
- hsa-mir-6792-3p (MIRT651106)
- hsa-mir-4691-5p (MIRT651107)
- hsa-mir-623 (MIRT651108)
- hsa-mir-4685-3p (MIRT651109)
- hsa-mir-4287 (MIRT651110)
- hsa-mir-7113-3p (MIRT651111)
- hsa-mir-4469 (MIRT651112)
- hsa-mir-26a-2-3p (MIRT651113)
- hsa-mir-26a-1-3p (MIRT651114)
- hsa-mir-6731-3p (MIRT651115)
- hsa-mir-1248 (MIRT651116)
- hsa-mir-1237-3p (MIRT651117)
- hsa-mir-3667-3p (MIRT651118)
- hsa-mir-5088-3p (MIRT651119)
- hsa-mir-4667-3p (MIRT651120)
- hsa-mir-1470 (MIRT651121)
- hsa-mir-6756-3p (MIRT651122)
- hsa-mir-3127-3p (MIRT651123)
- hsa-mir-211-5p (MIRT651124)
- hsa-mir-204-5p (MIRT651125)
miRNA Products
Inhibitory RNA Products
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ZNF48
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF48
- genomics-online: cdna clones - Search results for available ZNF48 gene related products
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- Applied Biological Materials Clones for ZNF48
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF48
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF48 Gene
Localization for ZNF48 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF48 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 3 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for ZNF48 Gene
No Data Available
Interacting Proteins for ZNF48 Gene
Selected Interacting proteins:
Q96MX3-ZNF48_HUMAN
ENSP00000324056
for ZNF48 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for ZNF48
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF48 Gene
Transcripts for ZNF48 Gene
mRNA/cDNA for ZNF48 Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (77) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000320159 3234 bps (uc002dya.2)
- ENST00000495929 430 bps (uc059tdq.1)
- ENST00000524644 912 bps (uc059tec.1)
- ENST00000528032 555 bps (uc059tdu.1)
- ENST00000613509 3339 bps (uc021tgk.2)
Unigene Clusters for ZNF48 Gene
- Zinc finger protein 48:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF48
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF48
- genomics-online: gRNA clones - Search results for available ZNF48 gene related products
- Applied Biological Materials CRISPR for ZNF48
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF48
- GenScript: Design CRISPR guide RNA sequences for ZNF48
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF48
- Browse OriGene Inhibitory RNA Products For ZNF48
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF48
- genomics-online: shRNA clones - Search results for available ZNF48 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZNF48
- VectorBuilder custom plasmid, inducible vectors for ZNF48
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF48
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF48
- genomics-online: cdna clones - Search results for available ZNF48 gene related products
- orf clones - Search results for available ZNF48 gene related products
- Applied Biological Materials Clones for ZNF48
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: |
Expression for ZNF48 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone marrow stromal cell (54.6) and Peripheral blood mononuclear cells (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF48 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF48 Gene:
ZNF48SOURCE GeneReport for Unigene cluster for ZNF48 Gene:
Hs.513501Evidence on tissue expression from TISSUES for ZNF48 Gene
- Nervous system(4.3)
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZNF48
-
OriGene qPCR primer pairs for ZNF48
- genomics-online: primer clones - Search results for available ZNF48 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF48 Gene
Orthologs for ZNF48 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF48 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF48 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF48 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zfp771 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp553 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF48 34 |
|
OneToOne |
- Species where no ortholog for ZNF48 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ZNF48 Gene
- ENSEMBL:
- Gene Tree for ZNF48 (if available)
- TreeFam:
- Gene Tree for ZNF48 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF48: view image
Paralogs for ZNF48 Gene
(76) SIMAP similar genes for ZNF48 Gene using alignment to 4 proteins:
- ZNF48_HUMAN
- E9PJ50_HUMAN
- E9PQ92_HUMAN
- F8W7I7_HUMAN
- ZNF78L1
- ZNF410
- HZF16
- ZNF
- kr-znf3
- ZFS-4
- A-328A3.4
- DKFZp434J0650
- ZFS-6
- PLZF
- ZNF72
- ZNF500
- ZFS-2
- ZNF697
- ZNF345
- ZNF286A
- ZNF55
- ZNF791
- ZNF808
- ZNF137P
- ZNF660
- ZNF84
- ZNF382
- ZNF844
- ZNF514
- ZKSCAN8
- ZNF696
- ZNF670
- ZNF649
- ZNF648
- ZNF627
- ZNF582
- ZNF569
- ZNF418
- ZNF271
- ZNF169
- ZNF501
- ZNF883
- ZNF850
- ZNF814
- ZNF615
- ZNF263
- ZNF16
- DKFZp547L155
- ZNF7
- ZNF558
- ZNF836
- ZNF721
- ZNF595
- ZNF470
- ZNF429
- ZNF347
- ZNF268
- ZNF184
- ZNF135
- DKFZp686B16128
- ZNF79
- HKR1
- ZNF672
- ZNF845
- ZNF616
- ZNF613
- ZNF605
- ZNF555
- ZNF546
- ZNF43
- ZNF304
- ZNF26
- ZNF225
- ZNF17
- ZNF33B
- ZNF337
- ZNF323
- ZNF219
- ZNF189
- ZNF107
No data available for Paralogs for ZNF48 Gene
Variants for ZNF48 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921000 | uncertain-significance, Malignant tumor of prostate | 30,398,874(+) | C/T | coding_sequence_variant, missense_variant | |
| rs386352335 | uncertain-significance, not provided | 30,377,821(+) | C/A/T | upstream_transcript_variant | |
| rs1000065551 | -- | 30,389,604(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000165138 | -- | 30,395,177(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000206884 | -- | 30,390,776(+) | A/G | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
9.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.33;
53.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF48 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF48
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF48 Gene
Disorders for ZNF48 Gene
Additional Disease Information for ZNF48
No disorders were found for ZNF48 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF48 Gene
Publications for ZNF48 Gene
- Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
Products for ZNF48 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 4 available ZNF48 Antibodies ranked by validation data
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- antibodies-online: Search results for available ZNF48 related products ranked by validation data
- antibodies-online: Search results for 1 available ZNF48 Proteins ranked by validation data
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Sources for ZNF48 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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