Aliases for ZNF479 Gene

Aliases for ZNF479 Gene

  • Zinc Finger Protein 479 2 3 4 5
  • Zinc Finger Protein Kr19 3 4
  • HKr19 3 4
  • KRAB Zinc Finger Protein KR19 3
  • KR19 3

External Ids for ZNF479 Gene

Previous GeneCards Identifiers for ZNF479 Gene

  • GC07M056965
  • GC07M056449
  • GC07M056998
  • GC07Mh57320
  • GC07M057191
  • GC07M057121

Summaries for ZNF479 Gene

GeneCards Summary for ZNF479 Gene

ZNF479 (Zinc Finger Protein 479) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF98.

UniProtKB/Swiss-Prot Summary for ZNF479 Gene

Additional gene information for ZNF479 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF479 Gene

Genomics for ZNF479 Gene

GeneHancer (GH) Regulatory Elements for ZNF479 Gene

Promoters and enhancers for ZNF479 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J057132 Promoter 0.3 EPDnew 750.4 +9.6 9588 0.1 ZNF479 ENSG00000286436 piR-35674-473 RF00017-6193
GH07J056658 Enhancer 0.2 FANTOM5 31.4 +483.1 483063 0.4 LOC102723684 lnc-SUMF2-5 ZNF479 piR-53374-001 RF00017-6187
GH07J056661 Enhancer 0.2 FANTOM5 19.6 +480.7 480678 0.1 ZNF479 LOC102723684 lnc-SUMF2-5 LOC105375289 RF00017-6187
GH07J057579 Enhancer 0.4 FANTOM5 1.5 -437.8 -437804 0.4 SMAD5 lnc-ZNF716-4 ZNF479 ZNF716 LOC105375301
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF479 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF479 gene promoter:
  • FOXI1
  • GATA-1
  • HFH-3
  • LCR-F1
  • Lmo2
  • MRF-2
  • POU2F1
  • POU2F1a
  • SEF-1 (1)
  • Sox9

Genomic Locations for ZNF479 Gene

Genomic Locations for ZNF479 Gene
22,430 bases
Minus strand
20,251 bases
Minus strand

Genomic View for ZNF479 Gene

Genes around ZNF479 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF479 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF479 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF479 Gene

Proteins for ZNF479 Gene

  • Protein details for ZNF479 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 479
    Protein Accession:

    Protein attributes for ZNF479 Gene

    524 amino acids
    Molecular mass:
    60598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF479 Gene

Post-translational modifications for ZNF479 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF479 Gene

Domains & Families for ZNF479 Gene

Gene Families for ZNF479 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF479 Gene

Suggested Antigen Peptide Sequences for ZNF479 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein Kr19 (ZN479_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF479: view

Function for ZNF479 Gene

Molecular function for ZNF479 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF479 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF479: view
genes like me logo Genes that share phenotypes with ZNF479: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF479

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF479 Gene

Localization for ZNF479 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF479 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF479 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF479 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF479: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF479 Gene

Pathways & Interactions for ZNF479 Gene

genes like me logo Genes that share pathways with ZNF479: view

Pathways by source for ZNF479 Gene

2 Reactome pathways for ZNF479 Gene
1 KEGG pathway for ZNF479 Gene

Gene Ontology (GO) - Biological Process for ZNF479 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF479: view

No data available for SIGNOR curated interactions for ZNF479 Gene

Drugs & Compounds for ZNF479 Gene

No Compound Related Data Available

Transcripts for ZNF479 Gene

mRNA/cDNA for ZNF479 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF479

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF479 Gene

No ASD Table

Relevant External Links for ZNF479 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF479 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF479 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF479 Gene

This gene is overexpressed in Testis (x52.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF479 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF479 Gene:


SOURCE GeneReport for Unigene cluster for ZNF479 Gene:


mRNA Expression by UniProt/SwissProt for ZNF479 Gene:

Tissue specificity: Expressed primarily in testis and fetal tissues.
genes like me logo Genes that share expression patterns with ZNF479: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF479 Gene

Orthologs for ZNF479 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF479 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100610454 32
  • 98.69 (n)
ZNF479 33
  • 98 (a)
(Bos Taurus)
Mammalia -- 33
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 51 (a)
-- 33
  • 37 (a)
(Mus musculus)
Mammalia Zfp456 33
  • 45 (a)
(Canis familiaris)
Mammalia -- 33
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 51 (a)
-- 33
  • 39 (a)
-- 33
  • 38 (a)
-- 33
  • 32 (a)
-- 33
  • 31 (a)
-- 33
  • 31 (a)
-- 33
  • 30 (a)
-- 33
  • 28 (a)
Species where no ortholog for ZNF479 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF479 Gene

Gene Tree for ZNF479 (if available)
Gene Tree for ZNF479 (if available)
Evolutionary constrained regions (ECRs) for ZNF479: view image

Paralogs for ZNF479 Gene

(538) SIMAP similar genes for ZNF479 Gene using alignment to 2 proteins:

  • ZN479_HUMAN
  • I0EZ75_HUMAN
genes like me logo Genes that share paralogs with ZNF479: view

Variants for ZNF479 Gene

Sequence variations from dbSNP and Humsavar for ZNF479 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000043548 -- 57,128,487(-) C/T intron_variant
rs1000325107 -- 57,133,592(-) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000335716 -- 57,140,219(-) T/C/G upstream_transcript_variant
rs1000371314 -- 57,138,605(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000696168 -- 57,137,619(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF479 Gene

Variant ID Type Subtype PubMed ID
dgv11354n54 CNV gain 21841781
dgv6367n100 CNV gain 25217958
dgv6368n100 CNV loss 25217958
esv2734468 CNV deletion 23290073
esv2734476 CNV deletion 23290073
esv2752160 CNV gain 17911159
esv2761119 CNV gain+loss 21179565
esv3576359 CNV gain 25503493
nsv1016541 CNV gain 25217958
nsv1024341 CNV gain 25217958
nsv607048 CNV gain 21841781
nsv966801 CNV duplication 23825009

Variation tolerance for ZNF479 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF479 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF479 Gene

Disorders for ZNF479 Gene

Additional Disease Information for ZNF479

No disorders were found for ZNF479 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF479 Gene

Publications for ZNF479 Gene

  1. Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. (PMID: 11410164) Mark C … Hellman L (DNA and cell biology 2001) 2 3 4 56
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  3. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S … Jans DA (Scientific reports 2015) 3 56

Products for ZNF479 Gene

Sources for ZNF479 Gene