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Aliases for ZNF474 Gene

Aliases for ZNF474 Gene

  • Zinc Finger Protein 474 2 3 5
  • Testis-Specific Zinc Finger Protein 3 4
  • TSZFP 3 4
  • 4933409D10Rik 3

External Ids for ZNF474 Gene

Previous GeneCards Identifiers for ZNF474 Gene

  • GC05P121494
  • GC05P116656
  • GC05P121465

Summaries for ZNF474 Gene

GeneCards Summary for ZNF474 Gene

ZNF474 (Zinc Finger Protein 474) is a Protein Coding gene. An important paralog of this gene is ENSG00000250803.

Additional gene information for ZNF474 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF474 Gene

Genomics for ZNF474 Gene

GeneHancer (GH) Regulatory Elements for ZNF474 Gene

Promoters and enhancers for ZNF474 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I122128 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 556.1 0.0 -11 2 KLF1 TEAD4 MAX SIN3A ZSCAN5C ZNF143 FOS RFX1 ZNF189 EP300 ZNF474 ENSG00000250803 LOC100505841 ENSG00000247311 LOX
GH05I122696 Enhancer 1.3 Ensembl ENCODE dbSUPER 39.6 +567.5 567548 1 ZNF493 ZNF529 ZFP64 MZF1 ZNF121 ZNF213 ZNF354C ZNF138 KLF7 ZNF214 CEP120 CSNK1G3 SNX2 ENSG00000260686 ZNF474 KRT8P33 SRFBP1 LOX SNCAIP RN7SL689P
GH05I121961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -167.1 -167097 2.8 CLOCK MLX DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 ZNF610 NBN SRFBP1 LOX SNX2 ENSG00000250803 ENSG00000247311 ZNF474
GH05I122125 Enhancer 1.3 Ensembl ENCODE dbSUPER 7.4 -2.8 -2788 2.6 PKNOX1 SMAD1 ARNT NCOA2 TCF12 GATA2 NCOA1 REST MBD2 MEF2D ENSG00000247311 ENSG00000249610 SRFBP1 ZNF474 LOX
GH05I122758 Enhancer 0.8 ENCODE 11.4 +630.5 630479 2.6 PKNOX1 ARNT FEZF1 YY1 ZNF213 EGR2 ZNF662 ZNF843 PRDM6 GLIS1 CSNK1G3 PPIC ENSG00000260686 ZNF474 CEP120 PRDM6 RN7SL689P LOC105379152 SNX2 LINC02201
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF474 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF474 gene promoter:

Genomic Locations for ZNF474 Gene

Genomic Locations for ZNF474 Gene
chr5:122,129,513-122,153,571
(GRCh38/hg38)
Size:
24,059 bases
Orientation:
Plus strand
chr5:121,465,208-121,515,312
(GRCh37/hg19)

Genomic View for ZNF474 Gene

Genes around ZNF474 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF474 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF474 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF474 Gene

Proteins for ZNF474 Gene

  • Protein details for ZNF474 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6S9Z5-ZN474_HUMAN
    Recommended name:
    Zinc finger protein 474
    Protein Accession:
    Q6S9Z5
    Secondary Accessions:
    • A8K4M0
    • Q96M07

    Protein attributes for ZNF474 Gene

    Size:
    364 amino acids
    Molecular mass:
    40315 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71507.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305};

neXtProt entry for ZNF474 Gene

Post-translational modifications for ZNF474 Gene

Other Protein References for ZNF474 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF474 Gene

Domains & Families for ZNF474 Gene

Gene Families for ZNF474 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF474 Gene

Suggested Antigen Peptide Sequences for ZNF474 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF474: view

No data available for UniProtKB/Swiss-Prot for ZNF474 Gene

Function for ZNF474 Gene

Gene Ontology (GO) - Molecular Function for ZNF474 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF474: view

Phenotypes for ZNF474 Gene

genes like me logo Genes that share phenotypes with ZNF474: view

Animal Model Products

CRISPR Products

miRNA for ZNF474 Gene

miRTarBase miRNAs that target ZNF474

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF474 Gene

Localization for ZNF474 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF474 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZNF474 Gene

Pathways & Interactions for ZNF474 Gene

SuperPathways for ZNF474 Gene

No Data Available

Interacting Proteins for ZNF474 Gene

Selected Interacting proteins: Q6S9Z5-ZN474_HUMAN for ZNF474 Gene via IID

Symbol External ID(s) Details
RREB1
ZNF202

Gene Ontology (GO) - Biological Process for ZNF474 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF474 Gene

Drugs & Compounds for ZNF474 Gene

No Compound Related Data Available

Transcripts for ZNF474 Gene

mRNA/cDNA for ZNF474 Gene

Unigene Clusters for ZNF474 Gene

Zinc finger protein 474:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF474 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3: -

Relevant External Links for ZNF474 Gene

GeneLoc Exon Structure for
ZNF474
ECgene alternative splicing isoforms for
ZNF474

Expression for ZNF474 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF474 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF474 Gene

This gene is overexpressed in Testis (x23.6).

NURSA nuclear receptor signaling pathways regulating expression of ZNF474 Gene:

ZNF474

SOURCE GeneReport for Unigene cluster for ZNF474 Gene:

Hs.729673

Evidence on tissue expression from TISSUES for ZNF474 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF474: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF474 Gene

Orthologs for ZNF474 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF474 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF474 33 34
  • 97.53 (n)
dog
(Canis familiaris)
Mammalia LOC474655 33
  • 84.25 (n)
ZNF474 34
  • 47 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC781423 33
  • 82.85 (n)
ZNF474 34
  • 46 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp474 33 16 34
  • 77.07 (n)
rat
(Rattus norvegicus)
Mammalia Zfp474 33
  • 76.41 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF474 34
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF474 34
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF474 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494841 33
  • 55.56 (n)
worm
(Caenorhabditis elegans)
Secernentea M153.4 33 34
  • 56.16 (n)
Species where no ortholog for ZNF474 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF474 Gene

ENSEMBL:
Gene Tree for ZNF474 (if available)
TreeFam:
Gene Tree for ZNF474 (if available)

Paralogs for ZNF474 Gene

Paralogs for ZNF474 Gene

Pseudogenes.org Pseudogenes for ZNF474 Gene

genes like me logo Genes that share paralogs with ZNF474: view

Variants for ZNF474 Gene

Sequence variations from dbSNP and Humsavar for ZNF474 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000094627 -- 122,130,181(+) A/T intron_variant
rs1000150827 -- 122,133,222(+) A/T intron_variant
rs1000162215 -- 122,132,917(+) T/C intron_variant
rs1000190745 -- 122,136,948(+) A/C/G intron_variant
rs1000204931 -- 122,131,159(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF474 Gene

Variant ID Type Subtype PubMed ID
esv3425509 CNV insertion 20981092

Variation tolerance for ZNF474 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.53; 88.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF474 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF474

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF474 Gene

Disorders for ZNF474 Gene

Additional Disease Information for ZNF474

No disorders were found for ZNF474 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF474 Gene

Publications for ZNF474 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF474 Gene

Sources for ZNF474 Gene

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