This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016... See more...

Aliases for ZNF473 Gene

Aliases for ZNF473 Gene

  • Zinc Finger Protein 473 2 3 4 5
  • Zinc Finger Protein 100 Homolog 3 4
  • KIAA1141 2 4
  • ZFP100 3 4
  • DKFZP434N043 2
  • HZFP100 2
  • Zfp-100 4
  • ZNF473 5
  • ZN473 3

External Ids for ZNF473 Gene

Previous GeneCards Identifiers for ZNF473 Gene

  • GC19P055221
  • GC19P050529
  • GC19P046905

Summaries for ZNF473 Gene

Entrez Gene Summary for ZNF473 Gene

  • This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF473 Gene

ZNF473 (Zinc Finger Protein 473) is a Protein Coding gene. Diseases associated with ZNF473 include Cervical Adenosquamous Carcinoma. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Tat-mediated elongation of the HIV-1 transcript. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF184.

UniProtKB/Swiss-Prot Summary for ZNF473 Gene

  • Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

Gene Wiki entry for ZNF473 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF473 Gene

Genomics for ZNF473 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF473 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF473 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF473

Top Transcription factor binding sites by QIAGEN in the ZNF473 gene promoter:
  • ATF6
  • Bach2
  • E2F
  • E2F-1
  • IRF-7A
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Zic1
  • ZIC2

Genomic Locations for ZNF473 Gene

Latest Assembly
chr19:50,025,714-50,053,414
(GRCh38/hg38)
Size:
27,701 bases
Orientation:
Plus strand

Previous Assembly
chr19:50,529,262-50,552,033
(GRCh37/hg19 by Entrez Gene)
Size:
22,772 bases
Orientation:
Plus strand

chr19:50,528,971-50,556,671
(GRCh37/hg19 by Ensembl)
Size:
27,701 bases
Orientation:
Plus strand

Genomic View for ZNF473 Gene

Genes around ZNF473 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF473 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF473 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF473 Gene

Proteins for ZNF473 Gene

  • Protein details for ZNF473 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR7-ZN473_HUMAN
    Recommended name:
    Zinc finger protein 473
    Protein Accession:
    Q8WTR7
    Secondary Accessions:
    • A8K8T7
    • Q9ULS9
    • Q9Y4Q7

    Protein attributes for ZNF473 Gene

    Size:
    871 amino acids
    Molecular mass:
    100182 Da
    Quaternary structure:
    • Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.
    SequenceCaution:
    • Sequence=BAA86455.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF473 Gene

neXtProt entry for ZNF473 Gene

Post-translational modifications for ZNF473 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF473 Gene

Domains & Families for ZNF473 Gene

Gene Families for ZNF473 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF473 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF473 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 100 homolog (ZN473_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WTR7

UniProtKB/Swiss-Prot:

ZN473_HUMAN :
  • The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF473: view

Function for ZNF473 Gene

Molecular function for ZNF473 Gene

UniProtKB/Swiss-Prot Function:
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

Phenotypes From GWAS Catalog for ZNF473 Gene

Gene Ontology (GO) - Molecular Function for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNF473: view
genes like me logo Genes that share phenotypes with ZNF473: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF473

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF473 Gene

Localization for ZNF473 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF473 Gene

Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF473 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0015030 Cajal body IDA 16714279
genes like me logo Genes that share ontologies with ZNF473: view

Pathways & Interactions for ZNF473 Gene

genes like me logo Genes that share pathways with ZNF473: view

Gene Ontology (GO) - Biological Process for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage IDA 16714279
GO:0008334 histone mRNA metabolic process TAS --
genes like me logo Genes that share ontologies with ZNF473: view

No data available for SIGNOR curated interactions for ZNF473 Gene

Drugs & Compounds for ZNF473 Gene

No Compound Related Data Available

Transcripts for ZNF473 Gene

mRNA/cDNA for ZNF473 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF473

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF473 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for ZNF473 Gene

GeneLoc Exon Structure for
ZNF473

Expression for ZNF473 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF473 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZNF473 Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for ZNF473 Gene

This gene is overexpressed in Monocytes (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF473 Gene



Protein tissue co-expression partners for ZNF473 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF473

SOURCE GeneReport for Unigene cluster for ZNF473 Gene:

Hs.440553

Evidence on tissue expression from TISSUES for ZNF473 Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF473: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF473 Gene

Orthologs for ZNF473 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF473 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF473 29 30
  • 99.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF473 29 30
  • 76.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp473 29
  • 71.13 (n)
Mouse
(Mus musculus)
Mammalia Zfp473 29 16 30
  • 70.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF473 30
  • 61 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF473 30
  • 26 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 38 (a)
ManyToMany
-- 30
  • 35 (a)
ManyToMany
-- 30
  • 33 (a)
ManyToMany
-- 30
  • 31 (a)
ManyToMany
CSA.1668 30
  • 29 (a)
ManyToMany
-- 30
  • 28 (a)
ManyToMany
Species where no ortholog for ZNF473 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF473 Gene

ENSEMBL:
Gene Tree for ZNF473 (if available)
TreeFam:
Gene Tree for ZNF473 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF473: view image
Alliance of Genome Resources:
Additional Orthologs for ZNF473

Paralogs for ZNF473 Gene

(514) SIMAP similar genes for ZNF473 Gene using alignment to 6 proteins:

  • ZN473_HUMAN
  • F8WEC7_HUMAN
  • M0QZY7_HUMAN
  • M0R032_HUMAN
  • M0R123_HUMAN
  • M0R2N2_HUMAN
genes like me logo Genes that share paralogs with ZNF473: view

Variants for ZNF473 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF473 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs869025232 Uncertain Significance: Ductal breast carcinoma 50,046,802(+) A/T
NM_015428.4(ZNF473):c.2359A>T (p.Arg787Ter)
NONSENSE
rs10419876 -- p.Ser59Gly
rs10419911 -- p.Ser74Gly
rs10424809 -- p.Thr654Ile
rs10426374 -- p.Ser662Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF473 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF473 Gene

Variant ID Type Subtype PubMed ID
dgv3622n100 CNV gain 25217958
esv2751796 CNV gain 17911159
esv2758766 CNV loss 17122850
esv3644630 CNV gain 21293372
esv3644635 CNV gain 21293372
nsv1062974 CNV gain 25217958
nsv1065753 CNV gain 25217958
nsv1067191 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv428369 CNV loss 18775914
nsv458722 CNV gain 19166990
nsv458723 CNV loss 19166990
nsv469748 CNV gain+loss 16826518
nsv579912 CNV gain 21841781
nsv579913 CNV gain 21841781
nsv579914 CNV loss 21841781
nsv9739 CNV gain+loss 18304495

Variation tolerance for ZNF473 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF473 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF473
Leiden Open Variation Database (LOVD)
ZNF473

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF473 Gene

Disorders for ZNF473 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF473 Gene - From: COP

Disorder Aliases PubMed IDs
cervical adenosquamous carcinoma
  • adenosquamous carcinoma of cervix
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF473

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF473: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF473 Gene

Publications for ZNF473 Gene

  1. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. (PMID: 16714279) Wagner EJ … Marzluff WF (RNA (New York, N.Y.) 2006) 3 4 22
  2. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. (PMID: 11782445) Dominski Z … Marzluff WF (Genes & development 2002) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. (PMID: 16914750) Wagner EJ … Marzluff WF (Molecular and cellular biology 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZNF473 Gene

Sources for ZNF473 Gene