Aliases for ZNF473 Gene
Aliases for ZNF473 Gene
External Ids for ZNF473 Gene
- HGNC: 23239
- Entrez Gene: 25888
- Ensembl: ENSG00000142528
- OMIM: 617908
- UniProtKB: Q8WTR7
Previous GeneCards Identifiers for ZNF473 Gene
- GC19P055221
- GC19P050529
- GC19P046905
Summaries for ZNF473 Gene
-
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
GeneCards Summary for ZNF473 Gene
ZNF473 (Zinc Finger Protein 473) is a Protein Coding gene. Among its related pathways are Gene Expression and Processing of Capped Intronless Pre-mRNA. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for ZNF473 Gene
-
Involved in histone 3-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
Additional gene information for ZNF473 Gene
- Monarch Initiative
- Search for ZNF473 at DataMed
- Search for ZNF473 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF473 Gene
Genomics for ZNF473 Gene
GeneHancer (GH) Regulatory Elements for ZNF473 Gene
Promoters and enhancers for ZNF473 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF473 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZNF473 gene promoter:
-
- ZIC2
- E2F-1
- E2F
- IRF-7A
- ATF6
- SREBP-1c
- SREBP-1b
- SREBP-1a
- Bach2
- Zic1
Regulatory Element Products
Genomic Locations for ZNF473 Gene
Genomic Locations for ZNF473 Gene
- chr19:50,025,383-50,053,414
- (GRCh38/hg38)
- Size:
- 28,032 bases
- Orientation:
- Plus strand
- chr19:50,528,971-50,556,671
- (GRCh37/hg19)
- Size:
- 27,701 bases
- Orientation:
- Plus strand
Genomic View for ZNF473 Gene
Genes around ZNF473 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
- 19q13.33 by Ensembl
ZNF473 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF473 Gene
Proteins for ZNF473 Gene
-
Protein details for ZNF473 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WTR7-ZN473_HUMAN
- Recommended name:
- Zinc finger protein 473
- Protein Accession:
- Q8WTR7
- A8K8T7
- Q9ULS9
- Q9Y4Q7
Protein attributes for ZNF473 Gene
- Size:
- 871 amino acids
- Molecular mass:
- 100182 Da
- Quaternary structure:
-
- Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.
- SequenceCaution:
-
- Sequence=BAA86455.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF473 Gene
Post-translational modifications for ZNF473 Gene
Other Protein References for ZNF473 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF473
- Novus Biologicals Antibodies for ZNF473
-
Abcam antibodies for ZNF473
- Invitrogen Antibodies for ZNF473 (AFLGC-ZNF473)
- Search GeneTex for Antibodies for ZNF473
Protein Products
-
OriGene Purified Proteins for ZNF473
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF473
- Origene Custom Protein Services for ZNF473
- Search GeneTex for Proteins for ZNF473
-
Abcam proteins for ZNF473
Assay Products
No data available for DME Specific Peptides for ZNF473 Gene
Domains & Families for ZNF473 Gene
Gene Families for ZNF473 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF473 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF473 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WTR7UniProtKB/Swiss-Prot:
ZN473_HUMAN :- The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
- Belongs to the krueppel C2H2-type zinc-finger protein family.
- Domain:
-
- The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF473 Gene
Molecular function for ZNF473 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in histone 3-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
Phenotypes From GWAS Catalog for ZNF473 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF473 Gene
- GenomeRNAi human phenotypes for ZNF473:
-
- Synthetic lethal with imatinib mesylate
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased ionizing radiation sensitivity
- Decreased influenza A virus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF473
-
CRISPR Products
-
OriGene CRISPR knockouts for ZNF473
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF473
- genomics-online: gRNA clones - Search results for available ZNF473 gene related products
- Applied Biological Materials CRISPR for ZNF473
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF473
- GenScript: Design CRISPR guide RNA sequences for ZNF473
miRNA for ZNF473 Gene
- miRTarBase miRNAs that target ZNF473
-
- hsa-mir-98-5p (MIRT027502)
- hsa-mir-877-3p (MIRT036944)
- hsa-mir-378a-3p (MIRT043880)
- hsa-mir-411-5p (MIRT200713)
- hsa-mir-4257 (MIRT200717)
- hsa-mir-4654 (MIRT200720)
- hsa-mir-4769-5p (MIRT200721)
- hsa-mir-2467-3p (MIRT200722)
- hsa-mir-5089-5p (MIRT200723)
- hsa-mir-6134 (MIRT200724)
- hsa-mir-142-3p (MIRT439201)
- hsa-mir-4764-3p (MIRT570771)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF473
- Browse OriGene Inhibitory RNA Products For ZNF473
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF473
- genomics-online: shRNA clones - Search results for available ZNF473 gene related products
Clone Products
-
OriGene ORF clones in human for ZNF473
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZNF473
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF473
- genomics-online: cdna clones - Search results for available ZNF473 gene related products
- orf clones - Search results for available ZNF473 gene related products
- Applied Biological Materials Clones for ZNF473
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF473
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF473 Gene
Localization for ZNF473 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF473 Gene
- Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0015030 | Cajal body | IDA | 16714279 |
Pathways & Interactions for ZNF473 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Processing of Capped Intronless Pre-mRNA | ||
| 2 | Cleavage of Growing Transcript in the Termination Region | ||
| 3 | Gene Expression |
.48
|
|
| 4 | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||
Pathways by source for ZNF473 Gene
Interacting Proteins for ZNF473 Gene
Selected Interacting proteins:
Q8WTR7-ZN473_HUMAN
ENSP00000270617
for ZNF473 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ZNF473
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
| GO:0006398 | mRNA 3-end processing by stem-loop binding and cleavage | IDA | 16714279 |
| GO:0008334 | histone mRNA metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for ZNF473 Gene
Transcripts for ZNF473 Gene
mRNA/cDNA for ZNF473 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000598809 605 bps (uc061bop.1)
- ENST00000595661 4828 bps (uc002prm.4)
- ENST00000391821 4715 bps (uc002prn.4)
- ENST00000445728 2833 bps (uc010ybo.3)
- ENST00000601364 603 bps (uc061bor.1)
Unigene Clusters for ZNF473 Gene
- Zinc finger protein 473:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF473
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF473
- genomics-online: gRNA clones - Search results for available ZNF473 gene related products
- Applied Biological Materials CRISPR for ZNF473
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF473
- GenScript: Design CRISPR guide RNA sequences for ZNF473
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF473
- Browse OriGene Inhibitory RNA Products For ZNF473
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF473
- genomics-online: shRNA clones - Search results for available ZNF473 gene related products
Clone Products
-
OriGene ORF clones in human for ZNF473
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZNF473
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF473
- genomics-online: cdna clones - Search results for available ZNF473 gene related products
- orf clones - Search results for available ZNF473 gene related products
- Applied Biological Materials Clones for ZNF473
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | - |
Expression for ZNF473 Gene
mRNA differential expression in normal tissues according to GTEx for ZNF473 Gene
This gene is overexpressed in Testis (x6.7).
This gene is overexpressed in Monocytes (67.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF473 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZNF473 Gene:
ZNF473SOURCE GeneReport for Unigene cluster for ZNF473 Gene:
Hs.440553Evidence on tissue expression from TISSUES for ZNF473 Gene
- Nervous system(4.2)
- Eye(4.1)
Primer Products
-
OriGene qPCR primer pairs for ZNF473
- genomics-online: primer clones - Search results for available ZNF473 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF473 Gene
Orthologs for ZNF473 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF473 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF473 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zfp473 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp473 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF473 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ZNF473 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| CSA.1668 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ZNF473 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ZNF473 Gene
- ENSEMBL:
- Gene Tree for ZNF473 (if available)
- TreeFam:
- Gene Tree for ZNF473 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF473: view image
Paralogs for ZNF473 Gene
(514) SIMAP similar genes for ZNF473 Gene using alignment to 6 proteins:
- ZN473_HUMAN
- F8WEC7_HUMAN
- M0QZY7_HUMAN
- M0R032_HUMAN
- M0R123_HUMAN
- M0R2N2_HUMAN
- DKFZp686J1732
- ZNF78L1
- kr-znf3
- ZNF55
- ZNF24
- HZF30
- zf30
- ZNF826P
- ZFS-5
- ZSCAN22
- ZNF550
- GLI4
- DKFZp762K012
- DKFZp666C237
- ZNF702P
- ZNF22
- ZNF204
- ZKSCAN1
- ZFS-4
- DKFZp686N14223
- ZNF
- ZNF3
- ZNF570
- ZFP41
- smap-7
- ZNF844
- ZNF829
- ZNF500
- ZNF79
- ZNF323
- ZNF286A
- ZNF213
- ZNF167
- ZNF146
- ZFS-6
- ZSCAN21
- ZNF726P1
- ZNF56
- ZNF542
- ZNF324
- ZNF286B
- ZNF232
- ZNF19
- ZFS-2
- DKFZp686M04222
- DKFZp686H10254
- DKFZp666M039
- DKFZp313M0722
- ZSCAN29
- ZNF72
- ZNF610
- ZNF554
- DKFZp686B16128
- ZNF410
- ZNF141
- ZFP1
- HZF36
- GZF1
- ZSCAN23
- ZNF679
- ZNF621
- ZNF675
- ZNF468
- ZNF391
- ZNF32
- ZNF282
- ZNF137P
- HZF40
- HZF16
- DKFZp434J0650
- ZKSCAN3
- ZNF696
- ZNF876P
- ZNF8
- ZNF768
- ZNF718
- ZNF571
- ZNF429
- ZNF35
- ZNF324B
- ZKSCAN8
- Nbla00121
- ZNF34
- ZNF557
- ZSCAN31
- ZSCAN26
- ZNF764
- ZNF697
- ZNF682
- ZNF660
- ZNF620
- ZNF586
- ZNF584
- ZNF724P
- ZNF708
- ZNF676
- ZNF189
- ZNF138
- DKFZp686O111
- ZNF160
- ZNF83
- ZNF420
- ZNF514
- ZNF664
- ZNF525
- ZNF737
- ZNF833P
- ZNF818P
- ZNF785
- ZNF766
- ZNF713
- ZNF619
- ZNF600
- ZNF595
- ZNF589
- ZNF878
- ZNF845
- ZNF573
- ZNF454
- ZNF30
- ZNF251
- ZNF135
- ZFS-1
- ZNF260
- ZNF234
- ZBTB17
- ZNF667
- ZNF345
- ZIM3
- ZNF569
- ZNF283
- ZNF740
- ZNF716
- ZNF70
- ZNF677
- ZNF599
- ZNF581
- ZNF501
- ZNF485
- ZNF98
- ZNF93
- ZNF90
- ZNF761
- ZNF665
- ZNF607
- ZNF492
- ZNF271
- DKFZp686K03205
- ZNF449
- ZNF436
- KLF1
- HZF28
- ZNF585B
- ZNF670
- ZNF729
- ZNF354A
- ZNF808
- ZNF517
- ZNF678
- ZNF66
- ZSCAN32
- ZNF92
- ZNF770
- ZNF705G
- ZNF577
- ZNF558
- ZNF498
- ZNF888
- ZNF880
- ZNF728
- ZNF721
- ZNF480
- ZNF254
- ZNF117
- ZNF471
- ZNF358
- ZNF354B
- ZNF331
- ZNF205
- ZNF2
- ZNF165
- ZNF107
- ZIC1
- ZBTB41
- RhitH
- HZF17
- GFI1B
- GFI1
- DKFZp686O1631
- DKFZp686D2168
- A-328A3.4
- ZNF91
- ZNF566
- ZNF691
- ZNF347
- KLF4
- ZNF568
- ZNF80
- ZNF790
- ZNF705E
- ZNF692
- ZNF605
- ZNF502
- ZNF483
- ZNF883
- ZNF816
- ZNF813
- ZNF497
- ZNF320
- ZNF28
- ZNF229
- ZNF225
- ZNF211
- ZNF14
- ZFP90
- HZF14
- DKFZp686G16228
- ZNF383
- ZNF355P
- ZNF302
- ZNF253
- ZNF25
- ZNF239
- ZNF180
- ZKSCAN4
- ZFS-3
- MST154
- ZNF85
- ZNF133
- ZNF717
- ZNF585A
- ZNF763
- ZNF726
- ZNF594
- ZFP64
- ZNF773
- ZNF76
- ZNF709
- ZNF707
- ZNF705F
- ZNF705D
- ZNF705B
- ZNF695
- ZNF649
- ZNF630
- ZNF506
- ZNF486
- ZSCAN2
- ZNF879
- ZNF841
- ZNF780A
- ZNF680
- ZNF658B
- ZNF658
- ZNF583
- ZNF543
- ZNF530
- ZNF493
- ZNF470
- ZNF273
- ZNF235
- ZNF224
- ZNF16
- ZKSCAN7
- ZFP2
- ZNF157
- ZFP14
- OSR2
- KLF13
- HKR1
- DKFZp547L155
- DKFZp434G1930
- ZNF780B
- ZNF99
- ZNF732
- ZNF578
- ZNF37A
- ZNF208
- ZNF101
- ZNF419
- ZSCAN30
- ZNF793
- ZNF771
- ZNF74
- ZNF736
- ZNF564
- ZNF852
- ZNF836
- ZNF730
- ZNF681
- ZNF534
- ZNF221
- ZNF182
- ZFP62
- HZF41
- DKFZp686H20223
- DKFZp571N1833
- ZNF45
- ZNF431
- ZNF418
- ZNF41
- ZNF23
- ZNF226
- ZNF134
- ZNF100
- ZFP30
- WT1
- PLAGL1
- MZF1
- DKFZp686L0787
- PRMD9
- ZNF805
- ZNF559
- ZNF582
- ZNF850
- ZFP3
- ZNF775
- ZNF540
- ZNF275
- PRDM9
- ZNF765
- ZNF735
- ZNF7
- ZNF662
- ZNF565
- ZNF527
- ZNF510
- ZNF479
- ZNF791
- ZNF720
- ZNF616
- ZNF611
- ZNF528
- ZFP95
- ZNF433
- ZNF268
- ZNF26
- ZNF197
- KIAA1829
- ZNF350
- ZNF529
- ZNF195
- ZNF778
- ZNF814
- ZNF623
- ZNF546
- ZNF440
- ZKSCAN5
- ZNF304
- ZNF789
- ZNF772
- ZNF71
- ZNF705A
- ZNF671
- ZNF846
- ZNF835
- ZNF799
- ZNF69
- ZNF624
- ZNF567
- ZNF132
- ZNF394
- ZNF33A
- ZNF333
- ZNF214
- ZFP37
- HZF11
- DKFZp686N0199
- DKFZp570I0164
- DKFZp547H249
- ZNF44
- ZNF417
- ZNF701
- ZNF674
- ZNF615
- ZNF33B
- ZNF337
- ZNF136
- ZNF672
- ZNF233
- ZNF812
- ZNF699
- ZNF648
- ZNF643
- ZNF625
- ZNF596
- ZNF587
- ZNF552
- ZNF547
- ZNF84
- ZNF81
- ZNF792
- ZNF714
- ZNF549
- ZNF443
- ZNF43
- ZNF404
- ZNF329
- ZNF17
- ZNF460
- ZNF432
- ZNF425
- ZNF397
- ZNF300
- ZNF284
- ZNF227
- ZNF20
- ZNF177
- ZNF175
- ZNF169
- ZNF140
- ZNF124
- ZFP92
- ZFP69B
- RBAK
- ZNF587B
- ZNF264
- ZNF257
- ZSCAN16
- ZNF655
- ZNF544
- ZNF382
- ZNF891
- ZNF774
- ZNF700
- ZNF613
- ZNF57
- ZNF563
- ZNF562
- ZNF548
- ZNF484
- ZNF840
- ZNF749
- ZNF572
- ZNF555
- ZNF430
- ZNF354C
- ZNF250
- ZNF112
- ZNF467
- ZNF426
- ZNF334
- ZNF263
- ZNF256
- ZNF248
- ZNF230
- ZNF223
- ZNF222
- ZNF219
- ZNF154
- ZNF10
- ZFP82
- ZFP69
- LOC126295
- GTF3A
- DKFZp686C13142
- ZNF823
- ZNF606
- ZNF684
- ZFP28
- ZNF561
- ZSCAN9
- ZNF827
- ZNF75A
- ZNF519
- ZNF860
- ZNF782
- ZNF266
- ZNF12
- ZFP112
- ZNF416
- ZNF322
- ZNF285A
- ZNF285
- ZNF121
- ZBTB47
- RREB1
- HKR3
- DKFZp572F2170
- CTCFL
- ZNF442
- ZNF551
- ZNF267
- ZNF184
- ZNF786
- ZSCAN10
- ZNFN1A2
- ZNF837
- ZNF776
- ZNF77
- ZNF73
- ZNF727
- ZNF669
- ZNF614
- ZNF788
- ZNF441
- ZNF311
- GD
- ZNF439
- ZNF415
- ZNF181
- ZNF155
- IKZF2
- ZNF689
- ZNF287
- ZSCAN12
- ZNF626
- ZNF597
- ZNF556
- ZNF490
- ZNF114
- ZIK1
- ZF6
- TIPUH1
No data available for Paralogs for ZNF473 Gene
Variants for ZNF473 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869025232 | uncertain-significance, Ductal breast carcinoma | 50,046,802(+) | A/T | coding_sequence_variant, stop_gained | |
| rs1000043122 | -- | 50,033,269(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000075776 | -- | 50,033,503(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000214111 | -- | 50,045,459(+) | A/T | coding_sequence_variant, missense_variant | |
| rs1000298521 | -- | 50,040,793(+) | C/A | 5_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3622n100 | CNV | gain | 25217958 |
| esv2751796 | CNV | gain | 17911159 |
| esv2758766 | CNV | loss | 17122850 |
| esv3644630 | CNV | gain | 21293372 |
| esv3644635 | CNV | gain | 21293372 |
| nsv1062974 | CNV | gain | 25217958 |
| nsv1065753 | CNV | gain | 25217958 |
| nsv1067191 | CNV | gain | 25217958 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv428369 | CNV | loss | 18775914 |
| nsv458722 | CNV | gain | 19166990 |
| nsv458723 | CNV | loss | 19166990 |
| nsv469748 | CNV | gain+loss | 16826518 |
| nsv579912 | CNV | gain | 21841781 |
| nsv579913 | CNV | gain | 21841781 |
| nsv579914 | CNV | loss | 21841781 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.54;
82.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF473 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF473
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF473 Gene
Disorders for ZNF473 Gene
Additional Disease Information for ZNF473
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ZNF473 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF473 Gene
Publications for ZNF473 Gene
- Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. (PMID: 16714279) Wagner EJ … Marzluff WF (RNA (New York, N.Y.) 2006) 3 4 22 58
- A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. (PMID: 11782445) Dominski Z … Marzluff WF (Genes & development 2002) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. (PMID: 16914750) Wagner EJ … Marzluff WF (Molecular and cellular biology 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for ZNF473 Gene
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Sources for ZNF473 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt