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Aliases for ZNF470 Gene

Aliases for ZNF470 Gene

  • Zinc Finger Protein 470 2 3 5
  • Chondrogenesis Zinc Finger Protein 1 3 4
  • CZF-1 3 4
  • CZF1 4

External Ids for ZNF470 Gene

Previous GeneCards Identifiers for ZNF470 Gene

  • GC19P061768
  • GC19P057078
  • GC19P053388

Summaries for ZNF470 Gene

GeneCards Summary for ZNF470 Gene

ZNF470 (Zinc Finger Protein 470) is a Protein Coding gene. Diseases associated with ZNF470 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF471.

UniProtKB/Swiss-Prot for ZNF470 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF470 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF470 Gene

Genomics for ZNF470 Gene

GeneHancer (GH) Regulatory Elements for ZNF470 Gene

Promoters and enhancers for ZNF470 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I056566 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 560.3 +0.5 520 2 ZNF133 INSM2 ZNF76 SIN3A GLI4 ZBTB40 YY1 ETS1 ZNF335 GLIS2 ENSG00000269696 ZNF470 PIR49103 ZNF550 ZNF667 ZNF304 ZNF17 ZNF548 ZNF549 ZNF580
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 59.5 +28.4 28359 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I056403 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 47.7 -162.9 -162932 2 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF416 ZNF207 ZNF583 ZNF582-AS1 ZNF582 ZFP28 ZNF470 ZNF471 FIZ1 ZNF460-AS1 ENSG00000269696 ZNF542P
GH19I055579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.3 -985.9 -985881 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF579 FIZ1 ZNF471 ZNF582 ZNF542P ZNF470 ENSG00000269696 ZFP28 ZNF583 ZNF582-AS1
GH19I056392 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 24.4 -173.5 -173515 1.7 ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF416 ZNF207 ZNF143 SP3 ZNF582-AS1 ZNF582 GC19P056396 PIR50744 FIZ1 ZNF471 ZNF542P ZNF304 ZNF470 ZNF835
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF470 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF470 gene promoter:

Genomic Locations for ZNF470 Gene

Genomic Locations for ZNF470 Gene
chr19:56,567,081-56,588,911
(GRCh38/hg38)
Size:
21,831 bases
Orientation:
Plus strand
chr19:57,078,880-57,100,279
(GRCh37/hg19)

Genomic View for ZNF470 Gene

Genes around ZNF470 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF470 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF470 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF470 Gene

Proteins for ZNF470 Gene

  • Protein details for ZNF470 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ECI4-ZN470_HUMAN
    Recommended name:
    Zinc finger protein 470
    Protein Accession:
    Q6ECI4
    Secondary Accessions:
    • A8MTW0
    • B9EGU1
    • Q6ZPA1
    • Q9Y2N9

    Protein attributes for ZNF470 Gene

    Size:
    717 amino acids
    Molecular mass:
    82650 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF470 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF470 Gene

Post-translational modifications for ZNF470 Gene

No Post-translational modifications

Other Protein References for ZNF470 Gene

No data available for DME Specific Peptides for ZNF470 Gene

Domains & Families for ZNF470 Gene

Gene Families for ZNF470 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF470 Gene

Suggested Antigen Peptide Sequences for ZNF470 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ECI4

UniProtKB/Swiss-Prot:

ZN470_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF470: view

Function for ZNF470 Gene

Molecular function for ZNF470 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF470 Gene

Gene Ontology (GO) - Molecular Function for ZNF470 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF470: view

Phenotypes for ZNF470 Gene

genes like me logo Genes that share phenotypes with ZNF470: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF470 Gene

Localization for ZNF470 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF470 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF470 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF470 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZNF470: view

Pathways & Interactions for ZNF470 Gene

SuperPathways for ZNF470 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF470: view

Pathways by source for ZNF470 Gene

2 Reactome pathways for ZNF470 Gene

Interacting Proteins for ZNF470 Gene

Gene Ontology (GO) - Biological Process for ZNF470 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF470: view

No data available for SIGNOR curated interactions for ZNF470 Gene

Drugs & Compounds for ZNF470 Gene

No Compound Related Data Available

Transcripts for ZNF470 Gene

Unigene Clusters for ZNF470 Gene

Zinc finger protein 470:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF470 Gene

No ASD Table

Relevant External Links for ZNF470 Gene

GeneLoc Exon Structure for
ZNF470
ECgene alternative splicing isoforms for
ZNF470

Expression for ZNF470 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF470 Gene

Protein differential expression in normal tissues from HIPED for ZNF470 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF470 Gene



Protein tissue co-expression partners for ZNF470 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF470 Gene:

ZNF470

SOURCE GeneReport for Unigene cluster for ZNF470 Gene:

Hs.204449

mRNA Expression by UniProt/SwissProt for ZNF470 Gene:

Q6ECI4-ZN470_HUMAN
Tissue specificity: Highly expressed in testis. Very low expression in thymus. No expression in other tissues tested. Expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells.

Evidence on tissue expression from TISSUES for ZNF470 Gene

  • Nervous system(4.2)
  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with ZNF470: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF470 Gene

Orthologs for ZNF470 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF470 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF470 33
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia ZNF470 33 34
  • 90.75 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
Species where no ortholog for ZNF470 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF470 Gene

ENSEMBL:
Gene Tree for ZNF470 (if available)
TreeFam:
Gene Tree for ZNF470 (if available)

Paralogs for ZNF470 Gene

(498) SIMAP similar genes for ZNF470 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF470 Gene

genes like me logo Genes that share paralogs with ZNF470: view

Variants for ZNF470 Gene

Sequence variations from dbSNP and Humsavar for ZNF470 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000327266 -- 56,570,497(+) C/T intron_variant
rs1000377712 -- 56,582,453(+) A/G 3_prime_UTR_variant
rs1000951101 -- 56,574,895(+) C/T intron_variant
rs1000986246 -- 56,581,143(+) C/T 3_prime_UTR_variant
rs1001202032 -- 56,583,342(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF470 Gene

Variant ID Type Subtype PubMed ID
nsv1055357 CNV gain 25217958
esv3583593 CNV loss 25503493

Variation tolerance for ZNF470 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF470 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF470

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF470 Gene

Disorders for ZNF470 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF470 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF470

genes like me logo Genes that share disorders with ZNF470: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF470 Gene

Publications for ZNF470 Gene

  1. Characterization and chondrocyte differentiation stage-specific expression of KRAB zinc-finger protein gene ZNF470. (PMID: 15302581) Hering TM … Johnstone B (Experimental cell research 2004) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for ZNF470 Gene

Sources for ZNF470 Gene

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