Aliases for ZNF470 Gene

Aliases for ZNF470 Gene

  • Zinc Finger Protein 470 2 3 4 5
  • CZF-1 2 3 4
  • Chondrogenesis Zinc Finger Protein 1 3 4
  • FLJ26175 2
  • ZNF470 5
  • CZF1 4

External Ids for ZNF470 Gene

Previous GeneCards Identifiers for ZNF470 Gene

  • GC19P061768
  • GC19P057078
  • GC19P053388

Summaries for ZNF470 Gene

GeneCards Summary for ZNF470 Gene

ZNF470 (Zinc Finger Protein 470) is a Protein Coding gene. Diseases associated with ZNF470 include Amyotrophic Lateral Sclerosis Type 6 and Amyotrophic Lateral Sclerosis 3. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZFP28.

UniProtKB/Swiss-Prot Summary for ZNF470 Gene

Additional gene information for ZNF470 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF470 Gene

Genomics for ZNF470 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF470 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF470 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF470

Top Transcription factor binding sites by QIAGEN in the ZNF470 gene promoter:
  • C/EBPbeta
  • Cdc5
  • CUTL1
  • STAT1

Genomic Locations for ZNF470 Gene

Genomic Locations for ZNF470 Gene
chr19:56,567,468-56,588,911
(GRCh38/hg38)
Size:
21,444 bases
Orientation:
Plus strand
chr19:57,078,880-57,100,279
(GRCh37/hg19)
Size:
21,400 bases
Orientation:
Plus strand

Genomic View for ZNF470 Gene

Genes around ZNF470 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF470 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF470 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF470 Gene

Proteins for ZNF470 Gene

  • Protein details for ZNF470 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ECI4-ZN470_HUMAN
    Recommended name:
    Zinc finger protein 470
    Protein Accession:
    Q6ECI4
    Secondary Accessions:
    • A8MTW0
    • B9EGU1
    • Q6ZPA1
    • Q9Y2N9

    Protein attributes for ZNF470 Gene

    Size:
    717 amino acids
    Molecular mass:
    82650 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85218.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF470 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF470 Gene

Post-translational modifications for ZNF470 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF470 Gene

No data available for DME Specific Peptides for ZNF470 Gene

Domains & Families for ZNF470 Gene

Gene Families for ZNF470 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF470 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF470 Gene

GenScript: Design optimal peptide antigens:
  • Chondrogenesis zinc finger protein 1 (ZN470_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ECI4

UniProtKB/Swiss-Prot:

ZN470_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF470: view

Function for ZNF470 Gene

Molecular function for ZNF470 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF470 Gene

Gene Ontology (GO) - Molecular Function for ZNF470 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF470: view
genes like me logo Genes that share phenotypes with ZNF470: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF470

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF470 Gene

Localization for ZNF470 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF470 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF470 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF470 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZNF470: view

Pathways & Interactions for ZNF470 Gene

genes like me logo Genes that share pathways with ZNF470: view

Pathways by source for ZNF470 Gene

2 Reactome pathways for ZNF470 Gene
1 KEGG pathway for ZNF470 Gene

Interacting Proteins for ZNF470 Gene

Gene Ontology (GO) - Biological Process for ZNF470 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF470: view

No data available for SIGNOR curated interactions for ZNF470 Gene

Drugs & Compounds for ZNF470 Gene

No Compound Related Data Available

Transcripts for ZNF470 Gene

mRNA/cDNA for ZNF470 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF470

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF470 Gene

No ASD Table

Relevant External Links for ZNF470 Gene

GeneLoc Exon Structure for
ZNF470

Expression for ZNF470 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF470 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Eye (Sensory Organs)

Protein differential expression in normal tissues from HIPED for ZNF470 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF470 Gene



Protein tissue co-expression partners for ZNF470 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF470

SOURCE GeneReport for Unigene cluster for ZNF470 Gene:

Hs.204449

mRNA Expression by UniProt/SwissProt for ZNF470 Gene:

Q6ECI4-ZN470_HUMAN
Tissue specificity: Highly expressed in testis. Very low expression in thymus. No expression in other tissues tested. Expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells.

Evidence on tissue expression from TISSUES for ZNF470 Gene

  • Nervous system(4.2)
  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with ZNF470: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF470 Gene

Orthologs for ZNF470 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF470 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF470 30
  • 99.3 (n)
Dog
(Canis familiaris)
Mammalia ZNF470 30 31
  • 90.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 48 (a)
OneToMany
Species where no ortholog for ZNF470 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF470 Gene

ENSEMBL:
Gene Tree for ZNF470 (if available)
TreeFam:
Gene Tree for ZNF470 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF470: view image

Paralogs for ZNF470 Gene

Paralogs for ZNF470 Gene

(498) SIMAP similar genes for ZNF470 Gene using alignment to 3 proteins:

  • ZN470_HUMAN
  • M0R0Q6_HUMAN
  • M0R2Y9_HUMAN

Pseudogenes.org Pseudogenes for ZNF470 Gene

genes like me logo Genes that share paralogs with ZNF470: view

Variants for ZNF470 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF470 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10421285 - p.Val23Leu
rs35077804 - p.Ile642Thr
rs3752179 - p.Lys254Arg
rs4801177 - p.Thr418Ile

Additional dbSNP identifiers (rs#s) for ZNF470 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF470 Gene

Variant ID Type Subtype PubMed ID
esv3583593 CNV loss 25503493
nsv1055357 CNV gain 25217958

Variation tolerance for ZNF470 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF470 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF470

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF470 Gene

Disorders for ZNF470 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF470 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis type 6
  • als6
amyotrophic lateral sclerosis 3
  • als3
amyotrophic lateral sclerosis type 5
  • als5
amyotrophic lateral sclerosis 1
  • als1
lynch syndrome i
  • colorectal cancer, hereditary nonpolyposis, type 1; hnpcc1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF470: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF470 Gene

Publications for ZNF470 Gene

  1. Characterization and chondrocyte differentiation stage-specific expression of KRAB zinc-finger protein gene ZNF470. (PMID: 15302581) Hering TM … Johnstone B (Experimental cell research 2004) 2 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. LINKIN, a new transmembrane protein necessary for cell adhesion. (PMID: 25437307) Kato M … Sternberg PW (eLife 2014) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3

Products for ZNF470 Gene

Sources for ZNF470 Gene