Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF468 Gene

Aliases for ZNF468 Gene

  • Zinc Finger Protein 468 2 3 4 5
  • Zinc Finger Protein ZNF468 3

External Ids for ZNF468 Gene

Previous GeneCards Identifiers for ZNF468 Gene

  • GC19M058034
  • GC19M053341
  • GC19M049669

Summaries for ZNF468 Gene

GeneCards Summary for ZNF468 Gene

ZNF468 (Zinc Finger Protein 468) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF888.

UniProtKB/Swiss-Prot for ZNF468 Gene

Additional gene information for ZNF468 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF468 Gene

Genomics for ZNF468 Gene

GeneHancer (GH) Regulatory Elements for ZNF468 Gene

Promoters and enhancers for ZNF468 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052896 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 606.2 -7.2 -7225 3.2 SP1 ZFX NKRF GTF2F1 ZNF687 NFIB POLR2A MLLT1 IKZF1 PKNOX1 ZNF320 ZNF468 ZNF888 ENSG00000283088
GH19J052856 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 616.3 +32.7 32675 3 SP1 ELF3 NKRF POLR2A SP5 PRDM1 KAT8 IKZF1 GMEB1 NRF1 ZNF468 ZNF28 ZNF320 GC19M052864
GH19J052889 Enhancer 0.6 ENCODE 612.8 -0.3 -307 2.4 CBFA2T2 TRIM24 SMARCA4 IKZF1 TCF12 NCOR1 NFIC DPF2 TAL1 ZEB2 ZNF468 ZNF320 ENSG00000268225 ENSG00000283088
GH19J052138 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 36.9 +750.9 750930 3.7 SP1 CTCF ZFX ELF3 NKRF POLR2A MLLT1 CEBPG AHR SP7 ZNF616 ZNF137P ZNF160 ZNF350 ZNF808 ENSG00000268970 ZNF600 ZNF816 ZNF836 ZNF577
GH19J053864 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.3 -978.5 -978539 9.8 SP1 ZNF652 ZFX ELF3 MNT ZNF148 POLR2A CEBPG RERE GTF2F1 MYADM ENSG00000228323 LOC105372457 ZNF845 ENSG00000269001 ZNF765 ENSG00000235681 ZNF816 LENG8-AS1 TPM3P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF468 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF468 gene promoter:
  • ATF6
  • HTF
  • Ik-1
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF468 Gene

Genomic Locations for ZNF468 Gene
chr19:52,838,010-52,890,375
(GRCh38/hg38)
Size:
52,366 bases
Orientation:
Minus strand
chr19:53,341,261-53,360,902
(GRCh37/hg19)
Size:
19,642 bases
Orientation:
Minus strand

Genomic View for ZNF468 Gene

Genes around ZNF468 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF468 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF468 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF468 Gene

Proteins for ZNF468 Gene

  • Protein details for ZNF468 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VIY5-ZN468_HUMAN
    Recommended name:
    Zinc finger protein 468
    Protein Accession:
    Q5VIY5
    Secondary Accessions:
    • A8MV20
    • Q5CZB8
    • Q5VIY4
    • Q68DI7

    Protein attributes for ZNF468 Gene

    Size:
    522 amino acids
    Molecular mass:
    60573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF468 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF468 Gene

Post-translational modifications for ZNF468 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF468 Gene

Domains & Families for ZNF468 Gene

Gene Families for ZNF468 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF468 Gene

Suggested Antigen Peptide Sequences for ZNF468 Gene

GenScript: Design optimal peptide antigens:
  • ZNF468 protein (Q6P514_HUMAN)
  • Zinc finger protein 468 (ZN468_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VIY5

UniProtKB/Swiss-Prot:

ZN468_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF468: view

Function for ZNF468 Gene

Molecular function for ZNF468 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF468 Gene

Gene Ontology (GO) - Molecular Function for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF468: view
genes like me logo Genes that share phenotypes with ZNF468: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF468

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF468 Gene

Localization for ZNF468 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF468 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF468 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF468: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF468 Gene

Pathways & Interactions for ZNF468 Gene

genes like me logo Genes that share pathways with ZNF468: view

Pathways by source for ZNF468 Gene

2 Reactome pathways for ZNF468 Gene
1 KEGG pathway for ZNF468 Gene

Interacting Proteins for ZNF468 Gene

Gene Ontology (GO) - Biological Process for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF468: view

No data available for SIGNOR curated interactions for ZNF468 Gene

Drugs & Compounds for ZNF468 Gene

No Compound Related Data Available

Transcripts for ZNF468 Gene

Unigene Clusters for ZNF468 Gene

Zinc finger protein 468:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF468

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF468 Gene

No ASD Table

Relevant External Links for ZNF468 Gene

GeneLoc Exon Structure for
ZNF468
ECgene alternative splicing isoforms for
ZNF468

Expression for ZNF468 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF468 Gene

Protein differential expression in normal tissues from HIPED for ZNF468 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF468 Gene



Protein tissue co-expression partners for ZNF468 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF468 Gene:

ZNF468

SOURCE GeneReport for Unigene cluster for ZNF468 Gene:

Hs.467223

mRNA Expression by UniProt/SwissProt for ZNF468 Gene:

Q5VIY5-ZN468_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in placenta, pancreas, and small intestine. Lower expression in colon, ovary, testis, prostate, thymus, spleen, kidney, and liver. No expression detected in heart and brain.

Evidence on tissue expression from TISSUES for ZNF468 Gene

  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF468: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF468 Gene

Orthologs for ZNF468 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF468 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF468 35 34
  • 98.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF813 34
  • 65.89 (n)
-- 35
  • 49 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF468 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF468 Gene

ENSEMBL:
Gene Tree for ZNF468 (if available)
TreeFam:
Gene Tree for ZNF468 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF468: view image

Paralogs for ZNF468 Gene

(593) SIMAP similar genes for ZNF468 Gene using alignment to 6 proteins:

  • ZN468_HUMAN
  • M0QYC0_HUMAN
  • M0QYE7_HUMAN
  • M0QZR5_HUMAN
  • M0R171_HUMAN
  • Q6P514_HUMAN
genes like me logo Genes that share paralogs with ZNF468: view

Variants for ZNF468 Gene

Sequence variations from dbSNP and Humsavar for ZNF468 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000139315 -- 52,839,742(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000280717 -- 52,859,069(-) A/G upstream_transcript_variant
rs1000435756 -- 52,854,159(-) A/G intron_variant
rs1000444926 -- 52,839,599(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000568923 -- 52,859,582(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF468 Gene

Variant ID Type Subtype PubMed ID
dgv1068e212 CNV gain 25503493
dgv1069e212 CNV loss 25503493
dgv148n111 CNV duplication 26073780
dgv18n14 CNV gain 18776910
dgv3629n100 CNV loss 25217958
dgv3630n100 CNV loss 25217958
dgv3631n100 CNV gain 25217958
dgv3632n100 CNV gain+loss 25217958
dgv3633n100 CNV gain 25217958
dgv3634n100 CNV gain 25217958
dgv3635n100 CNV gain+loss 25217958
dgv3636n100 CNV gain 25217958
dgv3637n100 CNV gain 25217958
dgv3638n100 CNV loss 25217958
dgv3639n100 CNV gain 25217958
dgv426n27 CNV loss 19166990
dgv529e201 CNV deletion 23290073
dgv6527n54 CNV gain 21841781
dgv6528n54 CNV loss 21841781
dgv6529n54 CNV gain 21841781
dgv74e203 CNV gain+loss 21179565
esv1004256 CNV deletion 20482838
esv21942 CNV gain 19812545
esv2421897 OTHER complex 20811451
esv2445065 CNV deletion 19546169
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718798 CNV deletion 23290073
esv2718799 CNV deletion 23290073
esv2718803 CNV deletion 23290073
esv2758768 CNV gain+loss 17122850
esv3351530 CNV duplication 20981092
esv3354022 CNV duplication 20981092
esv3365995 CNV duplication 20981092
esv3447119 CNV duplication 20981092
esv3574676 CNV gain 25503493
esv3583512 CNV loss 25503493
esv3644724 CNV loss 21293372
esv3644725 CNV gain 21293372
esv3893232 CNV loss 25118596
esv3893234 CNV gain 25118596
esv3893235 CNV loss 25118596
nsv1057118 CNV gain 25217958
nsv1060163 CNV loss 25217958
nsv1060555 CNV gain 25217958
nsv1064234 CNV gain 25217958
nsv1066098 CNV loss 25217958
nsv1066762 CNV gain 25217958
nsv1067010 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv1147763 CNV deletion 26484159
nsv1160660 CNV duplication 26073780
nsv2537 CNV deletion 18451855
nsv2538 CNV insertion 18451855
nsv436855 CNV insertion 17901297
nsv442470 CNV gain+loss 18776908
nsv458746 CNV gain 19166990
nsv458747 CNV gain 19166990
nsv458750 CNV loss 19166990
nsv458752 CNV loss 19166990
nsv517570 CNV gain+loss 19592680
nsv519916 CNV gain 19592680
nsv524151 CNV gain 19592680
nsv525329 CNV loss 19592680
nsv528436 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580034 CNV gain 21841781
nsv580035 CNV loss 21841781
nsv580036 CNV gain 21841781
nsv580038 CNV loss 21841781
nsv580041 CNV loss 21841781
nsv580043 CNV gain 21841781
nsv580044 CNV loss 21841781
nsv817858 CNV gain 17921354
nsv817859 CNV gain 17921354
nsv817860 CNV gain+loss 17921354
nsv819146 CNV gain 19587683
nsv819613 CNV gain 19587683
nsv828619 CNV gain 20364138
nsv828621 CNV loss 20364138
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009
nsv9744 CNV gain 18304495

Variation tolerance for ZNF468 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF468 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF468

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF468 Gene

Disorders for ZNF468 Gene

Additional Disease Information for ZNF468

No disorders were found for ZNF468 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF468 Gene

Publications for ZNF468 Gene

  1. A novel zinc finger gene ZNF468 with two co-expressional splice variants, ZNF468.1 and ZNF468.2. (PMID: 16144304) Sun L … Mao Y (Biochemical genetics 2005) 2 3 4 23 58
  2. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 58
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for ZNF468 Gene

Sources for ZNF468 Gene

Content
Loading form....