The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by... See more...

Aliases for ZNF467 Gene

Aliases for ZNF467 Gene

  • Zinc Finger Protein 467 2 3 4 5
  • Zfp467 2 3
  • EZI 2 3
  • Zinc Finger Protein EZI 3
  • ZNF467 5

External Ids for ZNF467 Gene

Previous GeneCards Identifiers for ZNF467 Gene

  • GC00U920638
  • GC07M148900
  • GC07M149094
  • GC07M149461
  • GC07M143537

Summaries for ZNF467 Gene

Entrez Gene Summary for ZNF467 Gene

  • The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by RefSeq, Aug 2016]

GeneCards Summary for ZNF467 Gene

ZNF467 (Zinc Finger Protein 467) is a Protein Coding gene. Diseases associated with ZNF467 include Pericoronitis and Mixed Malaria. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Developmental Biology. An important paralog of this gene is ZNF572.

UniProtKB/Swiss-Prot Summary for ZNF467 Gene

  • Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).

Additional gene information for ZNF467 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF467 Gene

Genomics for ZNF467 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF467 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF467 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF467

Top Transcription factor binding sites by QIAGEN in the ZNF467 gene promoter:
  • c-Ets-1
  • c-Myc
  • C/EBPalpha
  • FAC1
  • HEN1
  • Max
  • Nkx2-5
  • STAT3
  • Zic3

Genomic Locations for ZNF467 Gene

Genomic Locations for ZNF467 Gene
chr7:149,764,182-149,776,323
(GRCh38/hg38)
Size:
12,142 bases
Orientation:
Minus strand
chr7:149,461,271-149,470,568
(GRCh37/hg19)
Size:
9,298 bases
Orientation:
Minus strand

Genomic View for ZNF467 Gene

Genes around ZNF467 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF467 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF467 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF467 Gene

Proteins for ZNF467 Gene

  • Protein details for ZNF467 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7K2-ZN467_HUMAN
    Recommended name:
    Zinc finger protein 467
    Protein Accession:
    Q7Z7K2

    Protein attributes for ZNF467 Gene

    Size:
    595 amino acids
    Molecular mass:
    65124 Da
    Quaternary structure:
    • Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).

neXtProt entry for ZNF467 Gene

Post-translational modifications for ZNF467 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF467 Gene

Domains & Families for ZNF467 Gene

Gene Families for ZNF467 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF467 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF467 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 467 (ZN467_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7K2

UniProtKB/Swiss-Prot:

ZN467_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF467: view

Function for ZNF467 Gene

Molecular function for ZNF467 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).

Phenotypes From GWAS Catalog for ZNF467 Gene

Gene Ontology (GO) - Molecular Function for ZNF467 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF467: view
genes like me logo Genes that share phenotypes with ZNF467: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF467 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF467
  • Consensus sequence: TGGGGAAGGGCM Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF467

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF467 Gene

Localization for ZNF467 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF467 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF467 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF467 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF467: view

Pathways & Interactions for ZNF467 Gene

genes like me logo Genes that share pathways with ZNF467: view

Pathways by source for ZNF467 Gene

Gene Ontology (GO) - Biological Process for ZNF467 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF467: view

No data available for SIGNOR curated interactions for ZNF467 Gene

Drugs & Compounds for ZNF467 Gene

No Compound Related Data Available

Transcripts for ZNF467 Gene

mRNA/cDNA for ZNF467 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF467

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF467 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for ZNF467 Gene

GeneLoc Exon Structure for
ZNF467

Expression for ZNF467 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF467 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF467 Gene

This gene is overexpressed in Whole Blood (x16.9).

Protein differential expression in normal tissues from HIPED for ZNF467 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF467 Gene



Protein tissue co-expression partners for ZNF467 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF467

SOURCE GeneReport for Unigene cluster for ZNF467 Gene:

Hs.726477

Evidence on tissue expression from TISSUES for ZNF467 Gene

  • Lung(3.7)
genes like me logo Genes that share expression patterns with ZNF467: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF467 Gene

Orthologs for ZNF467 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF467 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF467 30 31
  • 99.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF467 30 31
  • 86.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF467 30 31
  • 85.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp467 30 17 31
  • 82.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp467 30
  • 82.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF467 31
  • 65 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
Species where no ortholog for ZNF467 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF467 Gene

ENSEMBL:
Gene Tree for ZNF467 (if available)
TreeFam:
Gene Tree for ZNF467 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF467: view image

Paralogs for ZNF467 Gene

(249) SIMAP similar genes for ZNF467 Gene using alignment to 2 proteins:

  • ZN467_HUMAN
  • C9JAX3_HUMAN
genes like me logo Genes that share paralogs with ZNF467: view

Variants for ZNF467 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF467 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs6965332 - p.Thr324Ala

Additional dbSNP identifiers (rs#s) for ZNF467 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF467 Gene

Variant ID Type Subtype PubMed ID
dgv11714n54 CNV loss 21841781
dgv11715n54 CNV loss 21841781
dgv11716n54 CNV loss 21841781
dgv3694n106 CNV deletion 24896259
dgv844n27 CNV loss 19166990
esv2759571 CNV gain 17122850
esv3576480 CNV gain 25503493
nsv469576 CNV loss 16826518
nsv517242 CNV loss 19592680
nsv521861 CNV loss 19592680
nsv608979 CNV loss 21841781
nsv831184 CNV gain 17160897
nsv951643 CNV deletion 24416366

Variation tolerance for ZNF467 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF467 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF467

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF467 Gene

Disorders for ZNF467 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF467 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pericoronitis
mixed malaria
  • malaria by more than one parasite
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF467: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF467 Gene

Publications for ZNF467 Gene

  1. A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. (PMID: 12426389) Nakayama K … Miyajima A (The EMBO journal 2002) 2 3 23
  2. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. (PMID: 17848547) Saijou E … Miyajima A (The Journal of biological chemistry 2007) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells. (PMID: 32032745) Gluscevic M … Deyle DR (Gene 2020) 3

Products for ZNF467 Gene

Sources for ZNF467 Gene