Aliases for ZNF462 Gene
External Ids for ZNF462 Gene
Previous GeneCards Identifiers for ZNF462 Gene
The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
GeneCards Summary for ZNF462 Gene
ZNF462 (Zinc Finger Protein 462) is a Protein Coding gene. Diseases associated with ZNF462 include Metopic Ridging-Ptosis-Facial Dysmorphism Syndrome and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF521.
UniProtKB/Swiss-Prot for ZNF462 Gene
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965).