Aliases for ZNF461 Gene

Aliases for ZNF461 Gene

  • Zinc Finger Protein 461 2 3 4 5
  • GIOT-1 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 1 3 4
  • GIOT1 3 4
  • Zinc Finger Protein 28 3
  • MGC33911 2
  • ZNF461 5
  • HZF28 3

External Ids for ZNF461 Gene

Previous GeneCards Identifiers for ZNF461 Gene

  • GC19M041822
  • GC19M037128
  • GC19M033596
  • GC19M036678
  • GC19M036705
  • GC19M039004
  • GC19M039145
  • GC19M039209
  • GC19M041422
  • GC19M036897
  • GC19M036914
  • GC19M037416
  • GC19M037745
  • GC19M038044
  • GC19M038338
  • GC19M038633
  • GC19M038875

Summaries for ZNF461 Gene

GeneCards Summary for ZNF461 Gene

ZNF461 (Zinc Finger Protein 461) is a Protein Coding gene. Diseases associated with ZNF461 include Lung Cancer. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZFP30.

UniProtKB/Swiss-Prot Summary for ZNF461 Gene

Additional gene information for ZNF461 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF461 Gene

Genomics for ZNF461 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF461 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF461 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF461

Top Transcription factor binding sites by QIAGEN in the ZNF461 gene promoter:
  • C/EBPbeta
  • Ik-1
  • Ik-3
  • RP58

Genomic Locations for ZNF461 Gene

Genomic Locations for ZNF461 Gene
chr19:36,636,618-36,666,853
(GRCh38/hg38)
Size:
30,236 bases
Orientation:
Minus strand
chr19:37,128,094-37,157,755
(GRCh37/hg19)
Size:
29,662 bases
Orientation:
Minus strand

Genomic View for ZNF461 Gene

Genes around ZNF461 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF461 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF461 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF461 Gene

Proteins for ZNF461 Gene

  • Protein details for ZNF461 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAF7-ZN461_HUMAN
    Recommended name:
    Zinc finger protein 461
    Protein Accession:
    Q8TAF7
    Secondary Accessions:
    • A8K9W9
    • Q6VSF7
    • Q9ULZ8

    Protein attributes for ZNF461 Gene

    Size:
    563 amino acids
    Molecular mass:
    66214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF461 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF461 Gene

Post-translational modifications for ZNF461 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF461 Gene

Domains & Families for ZNF461 Gene

Gene Families for ZNF461 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF461 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF461 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 28 (Q6RFR8_HUMAN)
  • Gonadotropin-inducible ovary transcription repressor 1 (ZN461_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAF7

UniProtKB/Swiss-Prot:

ZN461_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF461: view

Function for ZNF461 Gene

Molecular function for ZNF461 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF461 Gene

Gene Ontology (GO) - Molecular Function for ZNF461 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF461: view
genes like me logo Genes that share phenotypes with ZNF461: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF461

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF461 Gene

Localization for ZNF461 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF461 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF461 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF461 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF461: view

Pathways & Interactions for ZNF461 Gene

genes like me logo Genes that share pathways with ZNF461: view

Pathways by source for ZNF461 Gene

2 Reactome pathways for ZNF461 Gene
1 KEGG pathway for ZNF461 Gene

Gene Ontology (GO) - Biological Process for ZNF461 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF461: view

No data available for SIGNOR curated interactions for ZNF461 Gene

Drugs & Compounds for ZNF461 Gene

No Compound Related Data Available

Transcripts for ZNF461 Gene

mRNA/cDNA for ZNF461 Gene

8 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF461

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF461 Gene

No ASD Table

Relevant External Links for ZNF461 Gene

GeneLoc Exon Structure for
ZNF461

Expression for ZNF461 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF461 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF461 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF461

SOURCE GeneReport for Unigene cluster for ZNF461 Gene:

Hs.590972

mRNA Expression by UniProt/SwissProt for ZNF461 Gene:

Q8TAF7-ZN461_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.

Evidence on tissue expression from TISSUES for ZNF461 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF461: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF461 Gene

Orthologs for ZNF461 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF461 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF461 30
  • 99.75 (n)
-- 31
  • 54 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia ZNF461 30 31
  • 81.79 (n)
OneToOne
Species where no ortholog for ZNF461 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF461 Gene

ENSEMBL:
Gene Tree for ZNF461 (if available)
TreeFam:
Gene Tree for ZNF461 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF461: view image

Paralogs for ZNF461 Gene

Paralogs for ZNF461 Gene

(550) SIMAP similar genes for ZNF461 Gene using alignment to 6 proteins:

  • ZN461_HUMAN
  • B4DRP8_HUMAN
  • K7EIW1_HUMAN
  • K7EJM1_HUMAN
  • K7EKL0_HUMAN
  • K7ESQ5_HUMAN
genes like me logo Genes that share paralogs with ZNF461: view

Variants for ZNF461 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF461 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10419469 - p.Asn87Ser

Additional dbSNP identifiers (rs#s) for ZNF461 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF461 Gene

Variant ID Type Subtype PubMed ID
dgv660e214 CNV loss 21293372
esv34384 CNV loss 17911159
nsv1061250 CNV gain 25217958
nsv1064851 CNV loss 25217958
nsv2475 CNV insertion 18451855
nsv469794 CNV loss 16826518
nsv817833 CNV loss 17921354
nsv833817 CNV loss 17160897

Variation tolerance for ZNF461 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF461 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF461

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF461 Gene

Disorders for ZNF461 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF461 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF461

genes like me logo Genes that share disorders with ZNF461: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF461 Gene

Publications for ZNF461 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4. (PMID: 15004467) Dai J … Mao Y (Cytogenetic and genome research 2003) 2 3 4 23
  2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. (PMID: 11579202) Mizutani T … Miyamoto K (Molecular endocrinology (Baltimore, Md.) 2001) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for ZNF461 Gene

Sources for ZNF461 Gene