Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF460 Gene

Aliases for ZNF460 Gene

  • Zinc Finger Protein 460 2 3 5
  • Zinc Finger Protein 272 2 3 4
  • Zinc Finger Protein HZF8 3 4
  • ZNF272 3 4
  • HZF8 3

External Ids for ZNF460 Gene

Previous HGNC Symbols for ZNF460 Gene

  • ZNF272

Previous GeneCards Identifiers for ZNF460 Gene

  • GC19P062484
  • GC19P057793
  • GC19P054104

Summaries for ZNF460 Gene

Entrez Gene Summary for ZNF460 Gene

  • Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

GeneCards Summary for ZNF460 Gene

ZNF460 (Zinc Finger Protein 460) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF543.

UniProtKB/Swiss-Prot for ZNF460 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF460 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF460 Gene

Genomics for ZNF460 Gene

GeneHancer (GH) Regulatory Elements for ZNF460 Gene

Promoters and enhancers for ZNF460 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057278 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 569.6 +2.1 2068 6.7 ZFP64 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF460 ZNF460-AS1 ZNF264 ZNF805 ZNF134 ZNF543 ZNF549 ZNF17 ZNF329 ZNF256
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28 +903.8 903828 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.2 -684.0 -683968 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I057809 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +533.8 533810 7.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF552 TRIM28 ZNF264 ZNF805 ZNF543 ENSG00000269867 ZNF134 ZNF587 ZNF324B ZNF586
GH19I057499 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.7 +220.8 220813 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF48 YY1 ETS1 ZNF773 ZNF419 ZNF264 ZNF805 ZNF543 ZNF548 ZNF550 ZNF134 VN1R1 ZNF417
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF460 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF460 Gene

Genomic Locations for ZNF460 Gene
chr19:57,279,408-57,294,075
(GRCh38/hg38)
Size:
14,668 bases
Orientation:
Plus strand
chr19:57,791,419-57,805,436
(GRCh37/hg19)

Genomic View for ZNF460 Gene

Genes around ZNF460 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF460 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF460 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF460 Gene

Proteins for ZNF460 Gene

  • Protein details for ZNF460 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14592-ZN460_HUMAN
    Recommended name:
    Zinc finger protein 460
    Protein Accession:
    Q14592
    Secondary Accessions:
    • A4FU64
    • B4DNX9
    • Q2VPC7
    • Q6VSF8

    Protein attributes for ZNF460 Gene

    Size:
    562 amino acids
    Molecular mass:
    63665 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF460 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF460 Gene

Post-translational modifications for ZNF460 Gene

  • Ubiquitination at isoforms=2194 and isoforms=2287
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF460 Gene

No data available for DME Specific Peptides for ZNF460 Gene

Domains & Families for ZNF460 Gene

Gene Families for ZNF460 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF460 Gene

Graphical View of Domain Structure for InterPro Entry

Q14592

UniProtKB/Swiss-Prot:

ZN460_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF460: view

Function for ZNF460 Gene

Molecular function for ZNF460 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF460 Gene

Gene Ontology (GO) - Molecular Function for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF460: view
genes like me logo Genes that share phenotypes with ZNF460: view

miRNA for ZNF460 Gene

miRTarBase miRNAs that target ZNF460

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF460 Gene

Localization for ZNF460 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF460 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF460 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF460: view

Pathways & Interactions for ZNF460 Gene

SuperPathways for ZNF460 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF460: view

Pathways by source for ZNF460 Gene

2 Reactome pathways for ZNF460 Gene

Gene Ontology (GO) - Biological Process for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF460: view

No data available for SIGNOR curated interactions for ZNF460 Gene

Drugs & Compounds for ZNF460 Gene

No Compound Related Data Available

Transcripts for ZNF460 Gene

Unigene Clusters for ZNF460 Gene

Zinc finger protein 460:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF460 Gene

No ASD Table

Relevant External Links for ZNF460 Gene

GeneLoc Exon Structure for
ZNF460
ECgene alternative splicing isoforms for
ZNF460

Expression for ZNF460 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF460 Gene

Protein differential expression in normal tissues from HIPED for ZNF460 Gene

This gene is overexpressed in Lymph node (35.6), Placenta (26.3), and Ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF460 Gene



Protein tissue co-expression partners for ZNF460 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF460 Gene:

ZNF460

SOURCE GeneReport for Unigene cluster for ZNF460 Gene:

Hs.99971

mRNA Expression by UniProt/SwissProt for ZNF460 Gene:

Q14592-ZN460_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.

Evidence on tissue expression from TISSUES for ZNF460 Gene

  • Nervous system(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with ZNF460: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF460 Gene

Orthologs for ZNF460 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF460 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF460 33 34
  • 99.53 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 34
  • 46 (a)
ManyToMany
CU138542.3 34
  • 39 (a)
ManyToMany
Species where no ortholog for ZNF460 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF460 Gene

ENSEMBL:
Gene Tree for ZNF460 (if available)
TreeFam:
Gene Tree for ZNF460 (if available)

Paralogs for ZNF460 Gene

Paralogs for ZNF460 Gene

(516) SIMAP similar genes for ZNF460 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF460: view

Variants for ZNF460 Gene

Sequence variations from dbSNP and Humsavar for ZNF460 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000115705 -- 57,283,261(+) C/T intron_variant
rs1000184005 -- 57,287,956(+) T/C intron_variant
rs1000336512 -- 57,281,029(+) G/C intron_variant
rs1001224352 -- 57,284,107(+) A/G intron_variant
rs1001275933 -- 57,277,575(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF460 Gene

Variant ID Type Subtype PubMed ID
nsv580400 CNV gain 21841781

Variation tolerance for ZNF460 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF460 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF460

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF460 Gene

Disorders for ZNF460 Gene

Additional Disease Information for ZNF460

No disorders were found for ZNF460 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF460 Gene

Publications for ZNF460 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4. (PMID: 15004467) Dai J … Mao Y (Cytogenetic and genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF460 Gene

Sources for ZNF460 Gene