Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on z... See more...

Aliases for ZNF460 Gene

Aliases for ZNF460 Gene

  • Zinc Finger Protein 460 2 3 4 5
  • Zinc Finger Protein 272 2 3 4
  • Zinc Finger Protein HZF8 3 4
  • ZNF272 3 4
  • HZF8 3

External Ids for ZNF460 Gene

Previous HGNC Symbols for ZNF460 Gene

  • ZNF272

Previous GeneCards Identifiers for ZNF460 Gene

  • GC19P062484
  • GC19P057793
  • GC19P054104

Summaries for ZNF460 Gene

Entrez Gene Summary for ZNF460 Gene

  • Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

GeneCards Summary for ZNF460 Gene

ZNF460 (Zinc Finger Protein 460) is a Protein Coding gene. Diseases associated with ZNF460 include Colon Lymphoma and Cystathioninuria. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF543.

UniProtKB/Swiss-Prot Summary for ZNF460 Gene

Additional gene information for ZNF460 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF460 Gene

Genomics for ZNF460 Gene

GeneHancer (GH) Regulatory Elements for ZNF460 Gene

Promoters and enhancers for ZNF460 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF460 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF460

Genomic Locations for ZNF460 Gene

Genomic Locations for ZNF460 Gene
chr19:57,279,408-57,294,075
(GRCh38/hg38)
Size:
14,668 bases
Orientation:
Plus strand
chr19:57,791,419-57,805,436
(GRCh37/hg19)
Size:
14,018 bases
Orientation:
Plus strand

Genomic View for ZNF460 Gene

Genes around ZNF460 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF460 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF460 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF460 Gene

Proteins for ZNF460 Gene

  • Protein details for ZNF460 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14592-ZN460_HUMAN
    Recommended name:
    Zinc finger protein 460
    Protein Accession:
    Q14592
    Secondary Accessions:
    • A4FU64
    • B4DNX9
    • Q2VPC7
    • Q6VSF8

    Protein attributes for ZNF460 Gene

    Size:
    562 amino acids
    Molecular mass:
    63665 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF460 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF460 Gene

Post-translational modifications for ZNF460 Gene

  • Ubiquitination at Lys194 and Lys287
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF460 Gene

No data available for DME Specific Peptides for ZNF460 Gene

Domains & Families for ZNF460 Gene

Gene Families for ZNF460 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF460 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF460 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56994, highly similar to Zinc finger protein 460 (B4DNX9_HUMAN)
  • Zinc finger protein HZF8 (ZN460_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14592

UniProtKB/Swiss-Prot:

ZN460_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF460: view

Function for ZNF460 Gene

Molecular function for ZNF460 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF460 Gene

Gene Ontology (GO) - Molecular Function for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF460: view
genes like me logo Genes that share phenotypes with ZNF460: view

miRNA for ZNF460 Gene

miRTarBase miRNAs that target ZNF460

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF460 Gene

Localization for ZNF460 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF460 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF460 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF460: view

Pathways & Interactions for ZNF460 Gene

genes like me logo Genes that share pathways with ZNF460: view

Pathways by source for ZNF460 Gene

2 Reactome pathways for ZNF460 Gene
1 KEGG pathway for ZNF460 Gene

Gene Ontology (GO) - Biological Process for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF460: view

No data available for SIGNOR curated interactions for ZNF460 Gene

Drugs & Compounds for ZNF460 Gene

No Compound Related Data Available

Transcripts for ZNF460 Gene

mRNA/cDNA for ZNF460 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF460 Gene

No ASD Table

Relevant External Links for ZNF460 Gene

GeneLoc Exon Structure for
ZNF460

Expression for ZNF460 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF460 Gene

Protein differential expression in normal tissues from HIPED for ZNF460 Gene

This gene is overexpressed in Lymph node (35.6), Placenta (26.3), and Ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF460 Gene



Protein tissue co-expression partners for ZNF460 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF460

SOURCE GeneReport for Unigene cluster for ZNF460 Gene:

Hs.99971

mRNA Expression by UniProt/SwissProt for ZNF460 Gene:

Q14592-ZN460_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.

Evidence on tissue expression from TISSUES for ZNF460 Gene

  • Nervous system(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with ZNF460: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF460 Gene

Orthologs for ZNF460 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF460 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF460 31 30
  • 99.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 31
  • 46 (a)
ManyToMany
CU138542.3 31
  • 39 (a)
ManyToMany
Species where no ortholog for ZNF460 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF460 Gene

ENSEMBL:
Gene Tree for ZNF460 (if available)
TreeFam:
Gene Tree for ZNF460 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF460: view image

Paralogs for ZNF460 Gene

Paralogs for ZNF460 Gene

(516) SIMAP similar genes for ZNF460 Gene using alignment to 3 proteins:

  • ZN460_HUMAN
  • B4DNX9_HUMAN
  • M0R0J6_HUMAN
genes like me logo Genes that share paralogs with ZNF460: view

Variants for ZNF460 Gene

Additional dbSNP identifiers (rs#s) for ZNF460 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF460 Gene

Variant ID Type Subtype PubMed ID
nsv580400 CNV gain 21841781

Variation tolerance for ZNF460 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF460 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF460

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF460 Gene

Disorders for ZNF460 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF460 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colon lymphoma
  • colonic lymphoma
cystathioninuria
  • cystathionase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF460

genes like me logo Genes that share disorders with ZNF460: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF460 Gene

Publications for ZNF460 Gene

No publications were found for ZNF460 Gene.

Products for ZNF460 Gene