Aliases for ZNF454 Gene

Aliases for ZNF454 Gene

  • Zinc Finger Protein 454 2 3 4 5

External Ids for ZNF454 Gene

Previous GeneCards Identifiers for ZNF454 Gene

  • GC05P178436
  • GC05P178481
  • GC05P178300
  • GC05P178368
  • GC05P173094

Summaries for ZNF454 Gene

GeneCards Summary for ZNF454 Gene

ZNF454 (Zinc Finger Protein 454) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF568.

UniProtKB/Swiss-Prot Summary for ZNF454 Gene

Additional gene information for ZNF454 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF454 Gene

Genomics for ZNF454 Gene

GeneHancer (GH) Regulatory Elements for ZNF454 Gene

Promoters and enhancers for ZNF454 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF454 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF454 gene promoter:
  • AML1a
  • E47
  • Hand1
  • Pax-2
  • Pax-2a
  • Pax-4a
  • STAT5A
  • USF2

Genomic Locations for ZNF454 Gene

Genomic Locations for ZNF454 Gene
25,243 bases
Plus strand
25,243 bases
Plus strand

Genomic View for ZNF454 Gene

Genes around ZNF454 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF454 Gene

Proteins for ZNF454 Gene

  • Protein details for ZNF454 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 454
    Protein Accession:
    Secondary Accessions:
    • Q2M1P2
    • Q2M323

    Protein attributes for ZNF454 Gene

    522 amino acids
    Molecular mass:
    60008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF454 Gene

Post-translational modifications for ZNF454 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF454 Gene

Domains & Families for ZNF454 Gene

Gene Families for ZNF454 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF454 Gene

Suggested Antigen Peptide Sequences for ZNF454 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77767, highly similar to Homo sapiens zinc finger protein 454 (ZNF454), mRNA (Q2M1P2_HUMAN)
  • Zinc finger protein 454 (ZN454_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF454: view

Function for ZNF454 Gene

Molecular function for ZNF454 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF454 Gene

Gene Ontology (GO) - Molecular Function for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF454: view
genes like me logo Genes that share phenotypes with ZNF454: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF454 Gene

Localization for ZNF454 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF454 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF454 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF454: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF454 Gene

Pathways & Interactions for ZNF454 Gene

genes like me logo Genes that share pathways with ZNF454: view

Pathways by source for ZNF454 Gene

2 Reactome pathways for ZNF454 Gene
1 KEGG pathway for ZNF454 Gene

Gene Ontology (GO) - Biological Process for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF454: view

No data available for SIGNOR curated interactions for ZNF454 Gene

Drugs & Compounds for ZNF454 Gene

No Compound Related Data Available

Transcripts for ZNF454 Gene

mRNA/cDNA for ZNF454 Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF454 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -

Relevant External Links for ZNF454 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF454 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF454 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF454 Gene:


SOURCE GeneReport for Unigene cluster for ZNF454 Gene:


Evidence on tissue expression from TISSUES for ZNF454 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF454: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF454 Gene

Orthologs for ZNF454 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF454 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF454 33 32
  • 98.85 (n)
(Bos Taurus)
Mammalia ZNF454 33 32
  • 90 (n)
(Canis familiaris)
Mammalia ZNF454 33 32
  • 88.29 (n)
(Mus musculus)
Mammalia Zfp454 17 33 32
  • 81.35 (n)
(Rattus norvegicus)
Mammalia LOC102555919 32
  • 80.03 (n)
(Monodelphis domestica)
Mammalia -- 33
  • 47 (a)
Species where no ortholog for ZNF454 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF454 Gene

Gene Tree for ZNF454 (if available)
Gene Tree for ZNF454 (if available)
Evolutionary constrained regions (ECRs) for ZNF454: view image

Paralogs for ZNF454 Gene

Paralogs for ZNF454 Gene

(509) SIMAP similar genes for ZNF454 Gene using alignment to 1 proteins:

  • ZN454_HUMAN Pseudogenes for ZNF454 Gene

genes like me logo Genes that share paralogs with ZNF454: view

Variants for ZNF454 Gene

Sequence variations from dbSNP and Humsavar for ZNF454 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000110331 -- 178,961,476(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000130760 -- 178,943,240(+) C/T intron_variant
rs1000142881 -- 178,961,661(+) AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000356748 -- 178,966,210(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000453003 -- 178,955,148(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF454 Gene

Variant ID Type Subtype PubMed ID
dgv1065e199 CNV deletion 23128226
esv2731267 CNV deletion 23290073
esv3607732 CNV loss 21293372
esv3890769 CNV gain 25118596
nsv1120062 OTHER inversion 24896259
nsv328942 CNV deletion 16902084
nsv525129 CNV loss 19592680
nsv600489 CNV loss 21841781
nsv823356 CNV loss 20364138
nsv980769 CNV duplication 23825009

Variation tolerance for ZNF454 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF454 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF454 Gene

Disorders for ZNF454 Gene

Additional Disease Information for ZNF454

No disorders were found for ZNF454 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF454 Gene

Publications for ZNF454 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 56
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 56

Products for ZNF454 Gene

Sources for ZNF454 Gene