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Aliases for ZNF451 Gene
Aliases for ZNF451 Gene
External Ids for ZNF451 Gene
- HGNC: 21091
- Entrez Gene: 26036
- Ensembl: ENSG00000112200
- OMIM: 615708
- UniProtKB: Q9Y4E5
Previous GeneCards Identifiers for ZNF451 Gene
- GC06P056957
- GC06P057001
- GC06P057062
- GC06P056788
- GC06P056951
Summaries for ZNF451 Gene
GeneCards Summary for ZNF451 Gene
ZNF451 (Zinc Finger Protein 451) is a Protein Coding gene. Diseases associated with ZNF451 include Motion Sickness and Brown-Sequard Syndrome. An important paralog of this gene is PRDM1.
UniProtKB/Swiss-Prot Summary for ZNF451 Gene
-
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
Additional gene information for ZNF451 Gene
- HGNC(21091)
- Entrez Gene(26036)
- Ensembl(ENSG00000112200)
- OMIM(615708)
- UniProtKB(Q9Y4E5)
- Open Targets Platform(ENSG00000112200)
- Search for ZNF451 at DataMed
- Search for ZNF451 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF451 Gene
Genomics for ZNF451 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF451 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF451 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF451
- Top Transcription factor binding sites by QIAGEN in the ZNF451 gene promoter:
-
- ATF-2
- CUTL1
- E4BP4
- FOXJ2
- FOXJ2 (long isoform)
- GATA-1
- Lmo2
- POU3F2 (N-Oct-5b)
Genomic Locations for ZNF451 Gene
Genomic Locations for ZNF451 Gene
- chr6:57,086,844-57,170,305
- (GRCh38/hg38)
- Size:
- 83,462 bases
- Orientation:
- Plus strand
- chr6:56,951,642-57,035,105
- (GRCh37/hg19)
- Size:
- 83,464 bases
- Orientation:
- Plus strand
Genomic View for ZNF451 Gene
Genes around ZNF451 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by HGNC
- 6p12.1 by Entrez Gene
- 6p12.1 by Ensembl
ZNF451 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF451 Gene
Proteins for ZNF451 Gene
-
Protein details for ZNF451 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4E5-ZN451_HUMAN
- Recommended name:
- E3 SUMO-protein ligase ZNF451
- Protein Accession:
- Q9Y4E5
- Q5VVE9
- Q5VVF1
- Q86YE4
- Q8N380
- Q8TD15
- Q9C0G1
- Q9NQM1
Protein attributes for ZNF451 Gene
- Size:
- 1061 amino acids
- Molecular mass:
- 121484 Da
- Quaternary structure:
-
- Homooligomer. Interacts (via N-terminal region) with SUMO1 (PubMed:18656483). Interacts (via N-terminal region) with SUMO2 (PubMed:18656483, PubMed:26524494). Interacts simultaneously with two SUMO2 chains (PubMed:26524493, PubMed:26524494). Identified in a complex with SUMO2 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule (PubMed:26524493, PubMed:26524494). Interacts (via C-terminus) with ubiquitin (PubMed:18656483). Interacts (via N-terminal zinc-finger domains) with SMAD4 (via MH2 domain). Interacts with SMAD2 and SMAD3. Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4. Interacts with EP300. Inhibits interaction between EP300 and the SMAD4 complex (PubMed:24324267).
- SequenceCaution:
-
- Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH42450.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=AAH58853.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAA25502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21793.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF451 Gene
Post-translational modifications for ZNF451 Gene
- Sumoylated. Predominantly sumoylated on the N-terminal region that is important for interaction with SUMO1 and SUMO2 (PubMed:18656483, PubMed:26524493, PubMed:26524494). Sumoylation is important for localization in nuclear granules; desumoylation leads to diffuse nucleoplasmic location (PubMed:18656483). Autosumoylated (in vitro) (PubMed:26524493, PubMed:26524494). Sumoylation enhances E3 SUMO-protein ligase activity (PubMed:26524494).
-
Ubiquitination at Lys106, Lys139, Lys144, Lys153, Lys316, Lys357, Lys387, Lys423, Lys434, Lys452, Lys454, Lys464, Lys585, Lys779, Lys790, Lys817, Lys827, Lys832, Lys845, and Lys852
- NX_Q9Y4E5 (NX_Q9Y4E5-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ZNF451 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ZNF451 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ZNF451
- Novus Biologicals Antibodies for ZNF451
-
Abcam antibodies for ZNF451
- Invitrogen Antibodies for ZNF451 (AFLGC-ZNF451)
-
Boster Bio Antibodies for ZNF451
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF451
Protein Products
-
OriGene Purified Proteins for ZNF451
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF451
- Origene Custom Protein Services for ZNF451
No data available for DME Specific Peptides for ZNF451 Gene
Domains & Families for ZNF451 Gene
Gene Families for ZNF451 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF451 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF451 Gene
- GenScript: Design optimal peptide antigens:
-
- ZNF451 protein (Q4KMR5_HUMAN)
- Zinc finger protein 451 (Q5VVE8_HUMAN)
- Zinc finger protein 451 (Q5VVF0_HUMAN)
- Coactivator for steroid receptors (ZN451_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y4E5UniProtKB/Swiss-Prot:
ZN451_HUMAN :- Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
- Belongs to the krueppel C2H2-type zinc-finger protein family.
- Domain:
-
- Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF451 Gene
Molecular function for ZNF451 Gene
- UniProtKB/Swiss-Prot Function:
- E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
Enzyme Numbers (IUBMB) for ZNF451 Gene
Phenotypes From GWAS Catalog for ZNF451 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | IMP | 24324267 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF451 Gene
- MGI mutant phenotypes for ZNF451:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZNF451:
Animal Models for ZNF451 Gene
- MGI Knock Outs for ZNF451:
-
- Zfp451 Zfp451<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF451 - Select products 50% OFF >
- * ZNF451 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF451
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF451
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF451
miRNA for ZNF451 Gene
- miRTarBase miRNAs that target ZNF451
-
- hsa-miR-335-5p (MIRT017501)
- hsa-miR-124-3p (MIRT022431)
- hsa-let-7e-5p (MIRT051672)
- hsa-miR-4452 (MIRT445859)
- hsa-miR-183-3p (MIRT445860)
- hsa-miR-526b-5p (MIRT445861)
- hsa-miR-624-3p (MIRT445862)
- hsa-miR-4790-3p (MIRT449664)
- hsa-miR-548ax (MIRT449665)
- hsa-miR-5582-3p (MIRT449666)
- hsa-miR-548ao-5p (MIRT449667)
- hsa-miR-548f-3p (MIRT449668)
- hsa-miR-548e-3p (MIRT449669)
- hsa-miR-548az-3p (MIRT449670)
- hsa-miR-548ar-3p (MIRT449671)
- hsa-miR-548a-3p (MIRT449672)
- hsa-miR-6516-5p (MIRT463120)
- hsa-miR-455-3p (MIRT463121)
- hsa-miR-7641 (MIRT463122)
- hsa-miR-650 (MIRT463123)
- hsa-miR-3612 (MIRT463124)
- hsa-miR-4327 (MIRT463125)
- hsa-miR-6499-3p (MIRT463126)
- hsa-miR-4695-3p (MIRT463127)
- hsa-miR-1827 (MIRT463128)
- hsa-miR-4537 (MIRT463129)
- hsa-miR-1247-3p (MIRT463130)
- hsa-miR-6511a-5p (MIRT463131)
- hsa-miR-1910-3p (MIRT463132)
- hsa-miR-1273e (MIRT463133)
- hsa-miR-6799-5p (MIRT463134)
- hsa-miR-6851-5p (MIRT463135)
- hsa-miR-3689d (MIRT463136)
- hsa-miR-6134 (MIRT463137)
- hsa-miR-4524a-3p (MIRT463138)
- hsa-miR-219b-3p (MIRT463139)
- hsa-miR-4329 (MIRT463140)
- hsa-miR-6865-5p (MIRT463141)
- hsa-miR-6815-5p (MIRT463142)
- hsa-miR-302f (MIRT463143)
- hsa-miR-4666a-5p (MIRT505036)
- hsa-miR-203a-3p (MIRT505037)
- hsa-miR-4277 (MIRT532882)
- hsa-miR-9-3p (MIRT532883)
- hsa-miR-584-3p (MIRT532884)
- hsa-miR-3622b-3p (MIRT532885)
- hsa-miR-3622a-3p (MIRT532886)
- hsa-miR-6854-5p (MIRT532887)
- hsa-miR-4429 (MIRT532888)
- hsa-miR-320d (MIRT532889)
- hsa-miR-320c (MIRT532890)
- hsa-miR-320b (MIRT532891)
- hsa-miR-320a (MIRT532892)
- hsa-miR-4465 (MIRT532893)
- hsa-miR-26b-5p (MIRT532894)
- hsa-miR-26a-5p (MIRT532895)
- hsa-miR-1297 (MIRT532896)
- hsa-miR-4756-3p (MIRT532897)
- hsa-miR-5697 (MIRT532898)
- hsa-miR-5692a (MIRT532899)
- hsa-miR-6830-5p (MIRT532900)
- hsa-miR-4293 (MIRT532901)
- hsa-miR-4423-3p (MIRT671728)
- hsa-miR-6787-5p (MIRT671729)
- hsa-miR-663a (MIRT671730)
- hsa-miR-1908-5p (MIRT671731)
- hsa-miR-566 (MIRT671732)
- hsa-miR-4767 (MIRT671733)
- hsa-miR-6720-3p (MIRT671734)
- hsa-miR-3188 (MIRT671735)
- hsa-miR-20b-3p (MIRT671736)
- hsa-miR-3664-3p (MIRT671737)
- hsa-miR-6499-5p (MIRT671738)
- hsa-miR-4433a-3p (MIRT671739)
- hsa-miR-4459 (MIRT671740)
- hsa-miR-4768-3p (MIRT671741)
- hsa-miR-5690 (MIRT671742)
- hsa-miR-2114-5p (MIRT671743)
- hsa-miR-5588-3p (MIRT671744)
- hsa-miR-449c-5p (MIRT671745)
- hsa-miR-34b-5p (MIRT671746)
- hsa-miR-2682-5p (MIRT671747)
- hsa-miR-940 (MIRT671748)
- hsa-miR-6893-5p (MIRT671749)
- hsa-miR-6808-5p (MIRT671750)
- hsa-miR-4695-5p (MIRT671751)
- hsa-miR-510-5p (MIRT671752)
- hsa-miR-512-5p (MIRT671753)
- hsa-miR-6513-5p (MIRT674717)
- hsa-miR-887-5p (MIRT674718)
- hsa-miR-6780a-5p (MIRT674719)
- hsa-miR-6779-5p (MIRT674720)
- hsa-miR-3689c (MIRT674721)
- hsa-miR-3689b-3p (MIRT674722)
- hsa-miR-3689a-3p (MIRT674723)
- hsa-miR-30b-3p (MIRT674724)
- hsa-miR-1273h-5p (MIRT674725)
- hsa-miR-6788-5p (MIRT674726)
- hsa-miR-30c-2-3p (MIRT674727)
- hsa-miR-30c-1-3p (MIRT674728)
- hsa-miR-7977 (MIRT674729)
- hsa-miR-6802-5p (MIRT674730)
- hsa-miR-6883-5p (MIRT674731)
- hsa-miR-6785-5p (MIRT674732)
- hsa-miR-4728-5p (MIRT674733)
- hsa-miR-149-3p (MIRT674734)
- hsa-miR-7106-5p (MIRT674735)
- hsa-miR-383-3p (MIRT674736)
- hsa-miR-3913-5p (MIRT676862)
- hsa-miR-3122 (MIRT676863)
- hsa-miR-450a-1-3p (MIRT676864)
- hsa-miR-4474-3p (MIRT676865)
- hsa-miR-24-3p (MIRT676866)
- hsa-miR-4284 (MIRT676867)
- hsa-miR-4318 (MIRT676868)
- hsa-miR-5195-3p (MIRT686199)
- hsa-miR-145-5p (MIRT686200)
- hsa-miR-770-5p (MIRT686201)
- hsa-miR-4712-5p (MIRT686202)
- hsa-miR-1285-5p (MIRT686203)
- hsa-miR-101-5p (MIRT686204)
- hsa-miR-513c-3p (MIRT686205)
- hsa-miR-513a-3p (MIRT686206)
- hsa-miR-3606-3p (MIRT686207)
- hsa-miR-6500-3p (MIRT697348)
- hsa-miR-3614-5p (MIRT697349)
- hsa-miR-1285-3p (MIRT762230)
- hsa-miR-196a-3p (MIRT763521)
- hsa-miR-3187-5p (MIRT765333)
- hsa-miR-3613-3p (MIRT766015)
- hsa-miR-371a-5p (MIRT767194)
- hsa-miR-371b-5p (MIRT767233)
- hsa-miR-372-5p (MIRT767276)
- hsa-miR-373-5p (MIRT767324)
- hsa-miR-4738-3p (MIRT771835)
- hsa-miR-5189-5p (MIRT773583)
- hsa-miR-548g-3p (MIRT774394)
- hsa-miR-612 (MIRT775874)
- hsa-miR-616-5p (MIRT776035)
- hsa-miR-6512-3p (MIRT776969)
- hsa-miR-661 (MIRT777484)
- hsa-miR-6720-5p (MIRT777815)
- hsa-miR-6860 (MIRT780582)
- hsa-miR-939-3p (MIRT782851)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF451
- Browse OriGene Inhibitory RNA Products For ZNF451
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF451
Clone Products
- Applied Biological Materials (abm): Clones for ZNF451 - Select products 50% OFF >
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-
OriGene ORF clones in human for ZNF451
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZNF451
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF451
Cell Line Products
-
Horizon Cell Lines for ZNF451
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF451 Gene
Localization for ZNF451 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF451 Gene
- Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. {ECO:0000269 PubMed:18656483}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 24324267 |
| GO:0005654 | nucleoplasm | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for ZNF451 Gene
UniProtKB/Swiss-Prot Q9Y4E5-ZN451_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for ZNF451 Gene
Selected Interacting proteins:
Q9Y4E5-ZN451_HUMAN
ENSP00000359740
for ZNF451 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZNF451
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010468 | regulation of gene expression | IBA | 21873635 |
| GO:0016925 | protein sumoylation | IEA | -- |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IMP | 24324267 |
| GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter | IMP | 24324267 |
| GO:2000616 | negative regulation of histone H3-K9 acetylation | IMP | 24324267 |
No data available for Pathways by source and SIGNOR curated interactions for ZNF451 Gene
Transcripts for ZNF451 Gene
mRNA/cDNA for ZNF451 Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000357489 4998 nts (view in UCSC)
- ENST00000370702 458 nts (view in UCSC)
- ENST00000370706 5088 nts (view in UCSC)
- ENST00000370708 9478 nts (view in UCSC)
- ENST00000370710 375 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF451 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF451
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF451
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF451
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF451
- Browse OriGene Inhibitory RNA Products For ZNF451
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF451
Clone Products
- Applied Biological Materials (abm): Clones for ZNF451 - Select products 50% OFF >
- * ZNF451 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene ORF clones in human for ZNF451
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ZNF451 Gene
- GeneLoc Exon Structure for
- ZNF451
Expression for ZNF451 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Cerebrospinal fluid (67.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF451 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF451
SOURCE GeneReport for Unigene cluster for ZNF451 Gene:
Hs.485628Evidence on tissue expression from TISSUES for ZNF451 Gene
- Nervous system(4.7)
- Heart(2.5)
- Skin(2.5)
- Liver(2.3)
- Muscle(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for ZNF451
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF451 Gene
Orthologs for ZNF451 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF451 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF451 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF451 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zfp451 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp451 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | ZNF451 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZNF451 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZNF451 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf451 30 |
|
||
| Str.3549 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | znf451 30 31 |
|
OneToOne |
- Species where no ortholog for ZNF451 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZNF451 Gene
- ENSEMBL:
- Gene Tree for ZNF451 (if available)
- TreeFam:
- Gene Tree for ZNF451 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF451: view image
Paralogs for ZNF451 Gene
Paralogs for ZNF451 Gene
- PRDM1 5
- PRDM14 5
- PRDM10 5
- ZBTB16 5
- HIC1 5
- ZBTB7C 5
- ZBTB1 5
- ZNF143 5
- ZNF281 5
- PATZ1 5
- MTF1 5
- ZNF76 5
- ZNF276 5
- HIC2 5
- MAZ 5
- ZNF410 5
- ZBTB20 5
- ZNF362 5
- ZNF653 5
- ZNF384 5
- ZNF148 5
- SNAI2 5
- ZNF296 5
- SCRT2 5
- ZBTB18 5
- VEZF1 5
- ZFP91-CNTF 5
- ZFP91 5
- ZNF692 5
- PRDM6 5
- SCRT1 5
- ZNF575 5
- ZBTB32 5
- ZBTB42 5
- SNAI1 5
- SNAI3 5
- ZBTB45 5
- ENSG00000267477 5
(2) SIMAP similar genes for ZNF451 Gene using alignment to 10 proteins:
- ZN451_HUMAN
- D6RAS1_HUMAN
- D6RAV4_HUMAN
- D6RB93_HUMAN
- D6REC5_HUMAN
- D6RIA1_HUMAN
- E9PH99_HUMAN
- Q4KMR5_HUMAN
- Q5VVE8_HUMAN
- Q5VVF0_HUMAN
Variants for ZNF451 Gene
Residual Variation Intolerance Score:
11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.56;
30.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF451 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF451 Gene
Disorders for ZNF451 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| motion sickness |
|
|
| brown-sequard syndrome |
|
|
| peroneal neuropathy |
|
|
Search ZNF451 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF451
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF451 Gene
Publications for ZNF451 Gene
- A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. (PMID: 26524493) Eisenhardt N … Pichler A (Nature structural & molecular biology 2015) 2 3 4
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. (PMID: 26524494) Cappadocia L … Lima CD (Nature structural & molecular biology 2015) 3 4
- Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling. (PMID: 24324267) Feng Y … Feng XH (The Journal of biological chemistry 2014) 3 4
- ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. (PMID: 18656483) Karvonen U … Palvimo JJ (Journal of molecular biology 2008) 3 4
ExternalLinks
Products for ZNF451 Gene
- Custom Antibody ServicesOriGene Antibodies for ZNF451
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- Sino Biological Human cDNA Clone for ZNF451
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- Invitrogen Antibodies for ZNF451 (AFLGC-ZNF451)
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- antibodies-online: Show 10 available ZNF451 Antibodies ranked by validation data
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- antibodies-online: Search results for available ZNF451 related products ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for ZNF451
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- Santa Cruz Biotechnology (SCBT) CRISPR for ZNF451
- Horizon Cell Lines for ZNF451
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF451
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF451
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF451
- Boster Bio Antibodies for ZNF451
- Browse Boster Bio ELISA Kits
Sources for ZNF451 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB