Aliases for ZNF451 Gene

Aliases for ZNF451 Gene

  • Zinc Finger Protein 451 2 3 4 5
  • COASTER 2 3 4
  • E3 SUMO-Protein Transferase ZNF451 3 4
  • Coactivator For Steroid Receptors 3 4
  • E3 SUMO-Protein Ligase ZNF451 3 4
  • DJ417I1.1 2 3
  • KIAA0576 2 4
  • KIAA1702 2 4
  • EC 2.3.2.- 4
  • ZNF451 5

External Ids for ZNF451 Gene

Previous GeneCards Identifiers for ZNF451 Gene

  • GC06P056957
  • GC06P057001
  • GC06P057062
  • GC06P056788
  • GC06P056951

Summaries for ZNF451 Gene

GeneCards Summary for ZNF451 Gene

ZNF451 (Zinc Finger Protein 451) is a Protein Coding gene. Diseases associated with ZNF451 include Motion Sickness and Brown-Sequard Syndrome. An important paralog of this gene is PRDM1.

UniProtKB/Swiss-Prot Summary for ZNF451 Gene

  • E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).

Gene Wiki entry for ZNF451 Gene

Additional gene information for ZNF451 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF451 Gene

Genomics for ZNF451 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF451 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF451 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF451

Top Transcription factor binding sites by QIAGEN in the ZNF451 gene promoter:
  • ATF-2
  • CUTL1
  • E4BP4
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • Lmo2
  • POU3F2 (N-Oct-5b)

Genomic Locations for ZNF451 Gene

Genomic Locations for ZNF451 Gene
chr6:57,086,844-57,170,305
(GRCh38/hg38)
Size:
83,462 bases
Orientation:
Plus strand
chr6:56,951,642-57,035,105
(GRCh37/hg19)
Size:
83,464 bases
Orientation:
Plus strand

Genomic View for ZNF451 Gene

Genes around ZNF451 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF451 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF451 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF451 Gene

Proteins for ZNF451 Gene

  • Protein details for ZNF451 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E5-ZN451_HUMAN
    Recommended name:
    E3 SUMO-protein ligase ZNF451
    Protein Accession:
    Q9Y4E5
    Secondary Accessions:
    • Q5VVE9
    • Q5VVF1
    • Q86YE4
    • Q8N380
    • Q8TD15
    • Q9C0G1
    • Q9NQM1

    Protein attributes for ZNF451 Gene

    Size:
    1061 amino acids
    Molecular mass:
    121484 Da
    Quaternary structure:
    • Homooligomer. Interacts (via N-terminal region) with SUMO1 (PubMed:18656483). Interacts (via N-terminal region) with SUMO2 (PubMed:18656483, PubMed:26524494). Interacts simultaneously with two SUMO2 chains (PubMed:26524493, PubMed:26524494). Identified in a complex with SUMO2 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule (PubMed:26524493, PubMed:26524494). Interacts (via C-terminus) with ubiquitin (PubMed:18656483). Interacts (via N-terminal zinc-finger domains) with SMAD4 (via MH2 domain). Interacts with SMAD2 and SMAD3. Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4. Interacts with EP300. Inhibits interaction between EP300 and the SMAD4 complex (PubMed:24324267).
    SequenceCaution:
    • Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH42450.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=AAH58853.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAA25502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21793.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF451 Gene

    Alternative splice isoforms for ZNF451 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF451 Gene

Post-translational modifications for ZNF451 Gene

  • Sumoylated. Predominantly sumoylated on the N-terminal region that is important for interaction with SUMO1 and SUMO2 (PubMed:18656483, PubMed:26524493, PubMed:26524494). Sumoylation is important for localization in nuclear granules; desumoylation leads to diffuse nucleoplasmic location (PubMed:18656483). Autosumoylated (in vitro) (PubMed:26524493, PubMed:26524494). Sumoylation enhances E3 SUMO-protein ligase activity (PubMed:26524494).
  • Ubiquitination at Lys106, Lys139, Lys144, Lys153, Lys316, Lys357, Lys387, Lys423, Lys434, Lys452, Lys454, Lys464, Lys585, Lys779, Lys790, Lys817, Lys827, Lys832, Lys845, and Lys852
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF451 Gene

Domains & Families for ZNF451 Gene

Gene Families for ZNF451 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF451 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF451 Gene

GenScript: Design optimal peptide antigens:
  • ZNF451 protein (Q4KMR5_HUMAN)
  • Zinc finger protein 451 (Q5VVE8_HUMAN)
  • Zinc finger protein 451 (Q5VVF0_HUMAN)
  • Coactivator for steroid receptors (ZN451_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4E5

UniProtKB/Swiss-Prot:

ZN451_HUMAN :
  • Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF451: view

Function for ZNF451 Gene

Molecular function for ZNF451 Gene

UniProtKB/Swiss-Prot Function:
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).

Enzyme Numbers (IUBMB) for ZNF451 Gene

Phenotypes From GWAS Catalog for ZNF451 Gene

Gene Ontology (GO) - Molecular Function for ZNF451 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IMP 24324267
GO:0005515 protein binding IPI 16189514
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF451: view
genes like me logo Genes that share phenotypes with ZNF451: view

Animal Models for ZNF451 Gene

MGI Knock Outs for ZNF451:
  • Zfp451 Zfp451<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ZNF451 Gene

miRTarBase miRNAs that target ZNF451

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF451

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF451 Gene

Localization for ZNF451 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF451 Gene

Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. {ECO:0000269 PubMed:18656483}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF451 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF451 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 24324267
GO:0005654 nucleoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with ZNF451: view

Pathways & Interactions for ZNF451 Gene

PathCards logo

SuperPathways for ZNF451 Gene

No Data Available

UniProtKB/Swiss-Prot Q9Y4E5-ZN451_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Gene Ontology (GO) - Biological Process for ZNF451 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
GO:0016925 protein sumoylation IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 24324267
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter IMP 24324267
GO:2000616 negative regulation of histone H3-K9 acetylation IMP 24324267
genes like me logo Genes that share ontologies with ZNF451: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF451 Gene

Drugs & Compounds for ZNF451 Gene

No Compound Related Data Available

Transcripts for ZNF451 Gene

mRNA/cDNA for ZNF451 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF451

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF451 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for ZNF451 Gene

GeneLoc Exon Structure for
ZNF451

Expression for ZNF451 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF451 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF451 Gene

This gene is overexpressed in Cerebrospinal fluid (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF451 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF451

SOURCE GeneReport for Unigene cluster for ZNF451 Gene:

Hs.485628

Evidence on tissue expression from TISSUES for ZNF451 Gene

  • Nervous system(4.7)
  • Heart(2.5)
  • Skin(2.5)
  • Liver(2.3)
  • Muscle(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ZNF451: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF451 Gene

Orthologs for ZNF451 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF451 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF451 30 31
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF451 30 31
  • 91.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF451 30 31
  • 84.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp451 30 17 31
  • 82.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp451 30
  • 82.64 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 71 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ZNF451 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF451 30 31
  • 67.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF451 31
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf451 30
  • 59.56 (n)
Str.3549 30
Zebrafish
(Danio rerio)
Actinopterygii znf451 30 31
  • 50.78 (n)
OneToOne
Species where no ortholog for ZNF451 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF451 Gene

ENSEMBL:
Gene Tree for ZNF451 (if available)
TreeFam:
Gene Tree for ZNF451 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF451: view image

Paralogs for ZNF451 Gene

(2) SIMAP similar genes for ZNF451 Gene using alignment to 10 proteins:

  • ZN451_HUMAN
  • D6RAS1_HUMAN
  • D6RAV4_HUMAN
  • D6RB93_HUMAN
  • D6REC5_HUMAN
  • D6RIA1_HUMAN
  • E9PH99_HUMAN
  • Q4KMR5_HUMAN
  • Q5VVE8_HUMAN
  • Q5VVF0_HUMAN
genes like me logo Genes that share paralogs with ZNF451: view

Variants for ZNF451 Gene

Additional dbSNP identifiers (rs#s) for ZNF451 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF451 Gene

Variant ID Type Subtype PubMed ID
dgv1781e212 CNV gain 25503493
esv2732127 CNV deletion 23290073
nsv350038 CNV deletion 16902084
nsv462949 CNV loss 19166990
nsv5316 CNV insertion 18451855
nsv603190 CNV loss 21841781
nsv970717 CNV duplication 23825009

Variation tolerance for ZNF451 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF451 Gene

Human Gene Mutation Database (HGMD)
ZNF451
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF451

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF451 Gene

Disorders for ZNF451 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF451 Gene - From: DISEASES

Disorder Aliases PubMed IDs
motion sickness
  • travel sickness
brown-sequard syndrome
  • brown-squard syndrome
peroneal neuropathy
  • peroneal neuropathies
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF451: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF451 Gene

Publications for ZNF451 Gene

  1. A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. (PMID: 26524493) Eisenhardt N … Pichler A (Nature structural & molecular biology 2015) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  3. Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. (PMID: 26524494) Cappadocia L … Lima CD (Nature structural & molecular biology 2015) 3 4
  4. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling. (PMID: 24324267) Feng Y … Feng XH (The Journal of biological chemistry 2014) 3 4
  5. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. (PMID: 18656483) Karvonen U … Palvimo JJ (Journal of molecular biology 2008) 3 4

Products for ZNF451 Gene

Sources for ZNF451 Gene