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Aliases for ZNF45 Gene

Aliases for ZNF45 Gene

  • Zinc Finger Protein 45 2 3 5
  • Zinc Finger Protein 13 2 3 4
  • Zinc Finger Protein 45 (A Kruppel-Associated Box (KRAB) Domain Polypeptide) 2 3
  • Zinc Finger Protein KOX5 3 4
  • BRC1744 3 4
  • ZNF13 3 4
  • KOX5 3 4

External Ids for ZNF45 Gene

Previous HGNC Symbols for ZNF45 Gene

  • ZNF13

Previous GeneCards Identifiers for ZNF45 Gene

  • GC19M045062
  • GC19M044808
  • GC19M049092
  • GC19M049108
  • GC19M044416
  • GC19M040849

Summaries for ZNF45 Gene

GeneCards Summary for ZNF45 Gene

ZNF45 (Zinc Finger Protein 45) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF112.

UniProtKB/Swiss-Prot for ZNF45 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF45 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF45 Gene

Genomics for ZNF45 Gene

GeneHancer (GH) Regulatory Elements for ZNF45 Gene

Promoters and enhancers for ZNF45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043933 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 647.1 +0.3 250 2.1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 ZNF45 ZNF180 ZNF155 ZNF224 ZNF225 ZNF234 ZNF283 XRCC1 ZNF112 MRPS15P2
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 238.7 +155.4 155378 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 208.6 -230.0 -229970 1.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF226 ZNF45 ZNF180 ZNF225 ZNF155 ZNF224 ZNF227 ZNF284 ZNF234 ZNF112
GH19I044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 153.7 -177.7 -177721 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF112 ZNF224 ZNF226
GH19I043901 Promoter/Enhancer 1.5 Ensembl ENCODE 238.8 +33.5 33479 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF143 ZNF548 KLF13 SP3 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284 ZNF234
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF45 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF45 Gene

Genomic Locations for ZNF45 Gene
chr19:43,912,624-43,935,280
(GRCh38/hg38)
Size:
22,657 bases
Orientation:
Minus strand
chr19:44,416,776-44,439,430
(GRCh37/hg19)

Genomic View for ZNF45 Gene

Genes around ZNF45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF45 Gene

Proteins for ZNF45 Gene

  • Protein details for ZNF45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02386-ZNF45_HUMAN
    Recommended name:
    Zinc finger protein 45
    Protein Accession:
    Q02386
    Secondary Accessions:
    • P17016
    • P78472
    • Q9P1U9

    Protein attributes for ZNF45 Gene

    Size:
    682 amino acids
    Molecular mass:
    78242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF45 Gene

Post-translational modifications for ZNF45 Gene

  • Ubiquitination at isoforms=117
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF45 Gene

Domains & Families for ZNF45 Gene

Gene Families for ZNF45 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF45 Gene

Suggested Antigen Peptide Sequences for ZNF45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02386

UniProtKB/Swiss-Prot:

ZNF45_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF45: view

Function for ZNF45 Gene

Molecular function for ZNF45 Gene

GENATLAS Biochemistry:
zinc finger 45 with a Kruppel associated box A (KRAB) domain containing,widely expressed,involved in transcription repression
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF45 Gene

Gene Ontology (GO) - Molecular Function for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 9570955
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF45: view
genes like me logo Genes that share phenotypes with ZNF45: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF45 Gene

Localization for ZNF45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF45 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF45: view

Pathways & Interactions for ZNF45 Gene

SuperPathways for ZNF45 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF45: view

Pathways by source for ZNF45 Gene

2 Reactome pathways for ZNF45 Gene

Gene Ontology (GO) - Biological Process for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007275 multicellular organism development TAS 1559709
genes like me logo Genes that share ontologies with ZNF45: view

No data available for SIGNOR curated interactions for ZNF45 Gene

Drugs & Compounds for ZNF45 Gene

No Compound Related Data Available

Transcripts for ZNF45 Gene

Unigene Clusters for ZNF45 Gene

Zinc finger protein 45:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for ZNF45 Gene

GeneLoc Exon Structure for
ZNF45
ECgene alternative splicing isoforms for
ZNF45

Expression for ZNF45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF45 Gene

Protein differential expression in normal tissues from HIPED for ZNF45 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF45 Gene



Protein tissue co-expression partners for ZNF45 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF45 Gene:

ZNF45

SOURCE GeneReport for Unigene cluster for ZNF45 Gene:

Hs.381285

Evidence on tissue expression from TISSUES for ZNF45 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZNF45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF45 Gene

Orthologs for ZNF45 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF45 34 33
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF45 33 34
  • 87.09 (n)
cow
(Bos Taurus)
Mammalia ZNF45 33 34
  • 85.03 (n)
rat
(Rattus norvegicus)
Mammalia LOC102548695 33
  • 77.28 (n)
mouse
(Mus musculus)
Mammalia Zfp94 34
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS02740.8 35
  • 38 (a)
rgr 35
  • 37 (a)
Species where no ortholog for ZNF45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF45 Gene

ENSEMBL:
Gene Tree for ZNF45 (if available)
TreeFam:
Gene Tree for ZNF45 (if available)

Paralogs for ZNF45 Gene

(429) SIMAP similar genes for ZNF45 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF45: view

Variants for ZNF45 Gene

Sequence variations from dbSNP and Humsavar for ZNF45 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000043360 -- 43,935,756(-) G/A upstream_transcript_variant
rs1000151727 -- 43,926,366(-) C/T intron_variant
rs1000200746 -- 43,929,315(-) G/T intron_variant
rs1000261936 -- 43,935,985(-) A/G upstream_transcript_variant
rs1000445114 -- 43,921,519(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF45 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV gain 16826518
nsv510476 OTHER sequence alteration 20534489
nsv579854 CNV loss 21841781

Variation tolerance for ZNF45 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.59; 95.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF45 Gene

Human Gene Mutation Database (HGMD)
ZNF45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF45

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF45 Gene

Disorders for ZNF45 Gene

Additional Disease Information for ZNF45

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF45 Gene

Publications for ZNF45 Gene

  1. Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene. (PMID: 9067431) Constantinou Deltas C … Lee JE (Cytogenetics and cell genetics 1996) 2 3 4 58
  2. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A … Tienari PJ (Journal of neuroimmunology 2009) 3 44 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The identification and characterization of KRAB-domain-containing zinc finger proteins. (PMID: 1559709) Constantinou-Deltas CD … Lee JE (Genomics 1992) 3 4 58

Products for ZNF45 Gene

Sources for ZNF45 Gene

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