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Aliases for ZNF449 Gene

Aliases for ZNF449 Gene

  • Zinc Finger Protein 449 2 3 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 19 3 4
  • ZSCAN19 3 4

External Ids for ZNF449 Gene

Previous GeneCards Identifiers for ZNF449 Gene

  • GC00U911638
  • GC0XP134204
  • GC0XP134306
  • GC0XP134478
  • GC0XP123837

Summaries for ZNF449 Gene

Entrez Gene Summary for ZNF449 Gene

  • This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF449 Gene

ZNF449 (Zinc Finger Protein 449) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF394.

UniProtKB/Swiss-Prot for ZNF449 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF449 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF449 Gene

Genomics for ZNF449 Gene

GeneHancer (GH) Regulatory Elements for ZNF449 Gene

Promoters and enhancers for ZNF449 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ135340 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -1.3 -1288 5.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 PIR55917 ZNF75D ZNF449 RTL8B LOC105373342
GH0XJ135421 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.1 +77.3 77344 1.4 PKNOX1 RB1 SIN3A KLF14 ZNF335 EGR1 SCRT2 KLF7 EGR2 SP3 SMIM10L2A ZNF75D ZNF449 RNA5SP515 GC0XM135429
GH0XJ135097 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11 -246.4 -246357 2 PKNOX1 ATF1 KLF14 ZNF335 EGR1 SCRT2 CREM KLF13 EGR2 SP3 SMIM10L2B GC0XM135098 ZNF75D ZNF449 RTL8A NCLP2 SMIM10L2B-AS1
GH0XJ135307 Promoter 0.5 EPDnew 12.7 -37.0 -36996 0.1 ZNF75D ETDC ZNF449 LOC100421043
GH0XJ135351 Enhancer 0.3 FANTOM5 2 +6.9 6921 0 CT45A6 ZNF449 PIR39715
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF449 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF449 gene promoter:
  • HEN1
  • AREB6
  • Gfi-1
  • ZID
  • Nkx2-2
  • STAT1beta
  • STAT1alpha
  • STAT1
  • Arnt
  • AhR

Genomic Locations for ZNF449 Gene

Genomic Locations for ZNF449 Gene
18,657 bases
Plus strand
18,643 bases
Plus strand

Genomic View for ZNF449 Gene

Genes around ZNF449 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF449 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF449 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF449 Gene

Proteins for ZNF449 Gene

  • Protein details for ZNF449 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 449
    Protein Accession:
    Secondary Accessions:
    • Q5JRZ7
    • Q5JRZ8
    • Q6NZX2
    • Q8N3Q1
    • Q8TED7

    Protein attributes for ZNF449 Gene

    518 amino acids
    Molecular mass:
    59932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF449 Gene


neXtProt entry for ZNF449 Gene

Post-translational modifications for ZNF449 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF449 Gene

No data available for DME Specific Peptides for ZNF449 Gene

Domains & Families for ZNF449 Gene

Gene Families for ZNF449 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF449 Gene

Suggested Antigen Peptide Sequences for ZNF449 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF449: view

Function for ZNF449 Gene

Molecular function for ZNF449 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF449: view
genes like me logo Genes that share phenotypes with ZNF449: view

Animal Models for ZNF449 Gene

MGI Knock Outs for ZNF449:

Animal Model Products

miRNA for ZNF449 Gene

miRTarBase miRNAs that target ZNF449

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF449 Gene

Localization for ZNF449 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF449 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF449 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF449: view

Pathways & Interactions for ZNF449 Gene

SuperPathways for ZNF449 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007284 spermatogonial cell division IEA --
genes like me logo Genes that share ontologies with ZNF449: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF449 Gene

Drugs & Compounds for ZNF449 Gene

No Compound Related Data Available

Transcripts for ZNF449 Gene

mRNA/cDNA for ZNF449 Gene

Unigene Clusters for ZNF449 Gene

Zinc finger protein 449:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF449 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP4: -
SP6: -

Relevant External Links for ZNF449 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF449 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF449 Gene

Protein differential expression in normal tissues from HIPED for ZNF449 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF449 Gene

Protein tissue co-expression partners for ZNF449 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF449 Gene:


SOURCE GeneReport for Unigene cluster for ZNF449 Gene:

genes like me logo Genes that share expression patterns with ZNF449: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF449 Gene

Orthologs for ZNF449 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF449 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF449 34 33
  • 99.74 (n)
(Bos Taurus)
Mammalia ZNF449 34 33
  • 91.44 (n)
(Rattus norvegicus)
Mammalia Zfp449 33
  • 89.25 (n)
(Canis familiaris)
Mammalia ZNF449 34 33
  • 89.19 (n)
(Mus musculus)
Mammalia Zfp449 16 34 33
  • 88.55 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
-- 34
  • 34 (a)
-- 34
  • 33 (a)
-- 34
  • 30 (a)
Species where no ortholog for ZNF449 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF449 Gene

Gene Tree for ZNF449 (if available)
Gene Tree for ZNF449 (if available)
Evolutionary constrained regions (ECRs) for ZNF449: view image

Paralogs for ZNF449 Gene

Paralogs for ZNF449 Gene

(468) SIMAP similar genes for ZNF449 Gene using alignment to 2 proteins:

  • ZN449_HUMAN
  • Q7Z3P1_HUMAN Pseudogenes for ZNF449 Gene

genes like me logo Genes that share paralogs with ZNF449: view

Variants for ZNF449 Gene

Sequence variations from dbSNP and Humsavar for ZNF449 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000067138 -- 135,356,472(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000125013 -- 135,345,515(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001105754 -- 135,347,916(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1001304964 -- 135,344,850(+) G/T genic_upstream_transcript_variant, intron_variant
rs1001437664 -- 135,355,207(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF449 Gene

Variant ID Type Subtype PubMed ID
nsv528014 CNV gain 19592680
nsv469871 CNV loss 16826518
esv2758894 CNV gain 17122850

Variation tolerance for ZNF449 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF449 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF449 Gene

Disorders for ZNF449 Gene

Additional Disease Information for ZNF449

No disorders were found for ZNF449 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF449 Gene

Publications for ZNF449 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF449 Gene

Sources for ZNF449 Gene

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