Aliases for ZNF446 Gene

Aliases for ZNF446 Gene

  • Zinc Finger Protein 446 2 3 4 5
  • Zinc Finger Protein With KRAB And SCAN Domains 20 3 4
  • ZKSCAN20 3 4
  • ZSCAN30 3
  • ZSCAN52 3

External Ids for ZNF446 Gene

Previous GeneCards Identifiers for ZNF446 Gene

  • GC00U911635
  • GC19P063680
  • GC19P059044
  • GC19P059050
  • GC19P055296
  • GC19P059067
  • GC19P059082
  • GC19P059099
  • GC19P059136
  • GC19P059192
  • GC19P059232
  • GC19P059283

Summaries for ZNF446 Gene

GeneCards Summary for ZNF446 Gene

ZNF446 (Zinc Finger Protein 446) is a Protein Coding gene. Diseases associated with ZNF446 include Nephrolithiasis, Uric Acid and Cystinuria. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot Summary for ZNF446 Gene

Additional gene information for ZNF446 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF446 Gene

Genomics for ZNF446 Gene

GeneHancer (GH) Regulatory Elements for ZNF446 Gene

Promoters and enhancers for ZNF446 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF446 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF446

Top Transcription factor binding sites by QIAGEN in the ZNF446 gene promoter:
  • AP-1
  • ATF-2
  • Bach2
  • c-Jun
  • E47
  • NF-1
  • NF-1/L
  • STAT5A

Genomic Locations for ZNF446 Gene

Genomic Locations for ZNF446 Gene
chr19:58,474,017-58,489,533
(GRCh38/hg38)
Size:
15,517 bases
Orientation:
Plus strand
chr19:58,985,384-58,992,597
(GRCh37/hg19)
Size:
7,214 bases
Orientation:
Plus strand

Genomic View for ZNF446 Gene

Genes around ZNF446 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF446 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF446 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF446 Gene

Proteins for ZNF446 Gene

  • Protein details for ZNF446 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS9-ZN446_HUMAN
    Recommended name:
    Zinc finger protein 446
    Protein Accession:
    Q9NWS9
    Secondary Accessions:
    • Q96AF5

    Protein attributes for ZNF446 Gene

    Size:
    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF446 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF446 Gene

Post-translational modifications for ZNF446 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF446 Gene

No data available for DME Specific Peptides for ZNF446 Gene

Domains & Families for ZNF446 Gene

Gene Families for ZNF446 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF446 Gene

Blocks:
  • KRAB box
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF446 Gene

GenScript: Design optimal peptide antigens:
  • ZNF446 protein (Q96AF5_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 20 (ZN446_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NWS9

UniProtKB/Swiss-Prot:

ZN446_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF446: view

Function for ZNF446 Gene

Molecular function for ZNF446 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF446 Gene

Gene Ontology (GO) - Molecular Function for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with ZNF446: view
genes like me logo Genes that share phenotypes with ZNF446: view

Animal Model Products

CRISPR Products

miRNA for ZNF446 Gene

miRTarBase miRNAs that target ZNF446

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF446 Gene

Localization for ZNF446 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF446 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF446 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005615 extracellular space HDA 22664934
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF446: view

Pathways & Interactions for ZNF446 Gene

PathCards logo

SuperPathways for ZNF446 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF446: view

Pathways by source for ZNF446 Gene

2 Reactome pathways for ZNF446 Gene

Gene Ontology (GO) - Biological Process for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF446: view

No data available for SIGNOR curated interactions for ZNF446 Gene

Drugs & Compounds for ZNF446 Gene

No Compound Related Data Available

Transcripts for ZNF446 Gene

mRNA/cDNA for ZNF446 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for ZNF446 Gene

GeneLoc Exon Structure for
ZNF446

Expression for ZNF446 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF446 Gene

Protein differential expression in normal tissues from HIPED for ZNF446 Gene

This gene is overexpressed in Fetal ovary (33.7), Blymphocyte (24.3), and Testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF446 Gene



Protein tissue co-expression partners for ZNF446 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF446

SOURCE GeneReport for Unigene cluster for ZNF446 Gene:

Hs.710284

Evidence on tissue expression from TISSUES for ZNF446 Gene

  • Liver(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZNF446: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF446 Gene

Orthologs for ZNF446 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF446 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF446 31 30
  • 98.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF446 31 30
  • 80.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF446 31 30
  • 75.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp446 17 31 30
  • 69.49 (n)
rat
(Rattus norvegicus)
Mammalia LOC102552463 30
  • 69.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF446 31
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF446 31
  • 24 (a)
OneToOne
Species where no ortholog for ZNF446 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF446 Gene

ENSEMBL:
Gene Tree for ZNF446 (if available)
TreeFam:
Gene Tree for ZNF446 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF446: view image

Paralogs for ZNF446 Gene

Pseudogenes.org Pseudogenes for ZNF446 Gene

genes like me logo Genes that share paralogs with ZNF446: view

Variants for ZNF446 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF446 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1266909771 Uncertain Significance: Short stature 58,480,226(+) G/T MISSENSE_VARIANT,INTRON_VARIANT
rs1568616613 Uncertain Significance: Severe Myopia 58,477,439(+) T/G MISSENSE_VARIANT
rs201395980 Uncertain Significance: Short stature 58,480,613(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
rs776780438 Pathogenic: Short stature 58,480,401(+) G/A NONSENSE,INTRON_VARIANT
rs36095067 - p.Pro300Ser

Additional dbSNP identifiers (rs#s) for ZNF446 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF446 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1116353 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833888 CNV loss 17160897
nsv952156 CNV deletion 24416366

Variation tolerance for ZNF446 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF446 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF446

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF446 Gene

Disorders for ZNF446 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF446 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nephrolithiasis, uric acid
  • nephrolithiasis, uric acid, susceptibility to
cystinuria
  • csnu
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF446

genes like me logo Genes that share disorders with ZNF446: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF446 Gene

Publications for ZNF446 Gene

No publications were found for ZNF446 Gene.

Products for ZNF446 Gene

Sources for ZNF446 Gene