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Aliases for ZNF446 Gene

Aliases for ZNF446 Gene

  • Zinc Finger Protein 446 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 20 3 4
  • ZKSCAN20 3 4
  • ZSCAN30 3
  • ZSCAN52 3

External Ids for ZNF446 Gene

Previous GeneCards Identifiers for ZNF446 Gene

  • GC00U911635
  • GC19P063680
  • GC19P059044
  • GC19P059050
  • GC19P055296
  • GC19P059067
  • GC19P059082
  • GC19P059099
  • GC19P059136
  • GC19P059192
  • GC19P059232
  • GC19P059283

Summaries for ZNF446 Gene

GeneCards Summary for ZNF446 Gene

ZNF446 (Zinc Finger Protein 446) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF18.

UniProtKB/Swiss-Prot for ZNF446 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF446 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF446 Gene

Genomics for ZNF446 Gene

GeneHancer (GH) Regulatory Elements for ZNF446 Gene

Promoters and enhancers for ZNF446 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058474 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +2.1 2140 3.8 HNRNPUL1 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLR2B ZNF766 ENSG00000269106 GC19P058540 GC19P058541 ZNF446 ZNF584 TRIM28 ZNF274 ZNF586 ZNF134 RPS5
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 72.1 -147.1 -147146 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.9 +45.7 45691 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZSCAN22 ZNF549 ZNF274
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.2 -92.9 -92932 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 51.4 -874.0 -873980 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF446 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF446 gene promoter:

Genomic Locations for ZNF446 Gene

Genomic Locations for ZNF446 Gene
15,517 bases
Plus strand

Genomic View for ZNF446 Gene

Genes around ZNF446 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF446 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF446 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF446 Gene

Proteins for ZNF446 Gene

  • Protein details for ZNF446 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 446
    Protein Accession:
    Secondary Accessions:
    • Q96AF5

    Protein attributes for ZNF446 Gene

    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF446 Gene


neXtProt entry for ZNF446 Gene

Post-translational modifications for ZNF446 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF446 Gene

Domains & Families for ZNF446 Gene

Gene Families for ZNF446 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF446 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF446: view

Function for ZNF446 Gene

Molecular function for ZNF446 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF446 Gene

Gene Ontology (GO) - Molecular Function for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with ZNF446: view
genes like me logo Genes that share phenotypes with ZNF446: view

miRNA for ZNF446 Gene

miRTarBase miRNAs that target ZNF446

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF446 Gene

Localization for ZNF446 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF446 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF446 gene
Compartment Confidence
extracellular 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,HDA 22664934
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with ZNF446: view

Pathways & Interactions for ZNF446 Gene

SuperPathways for ZNF446 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF446: view

Pathways by source for ZNF446 Gene

2 Reactome pathways for ZNF446 Gene

Gene Ontology (GO) - Biological Process for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF446: view

No data available for SIGNOR curated interactions for ZNF446 Gene

Drugs & Compounds for ZNF446 Gene

No Compound Related Data Available

Transcripts for ZNF446 Gene

Unigene Clusters for ZNF446 Gene

Zinc finger protein 446:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for ZNF446 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF446 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF446 Gene

Protein differential expression in normal tissues from HIPED for ZNF446 Gene

This gene is overexpressed in Fetal ovary (33.7), Blymphocyte (24.3), and Testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF446 Gene

Protein tissue co-expression partners for ZNF446 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF446 Gene:


SOURCE GeneReport for Unigene cluster for ZNF446 Gene:


Evidence on tissue expression from TISSUES for ZNF446 Gene

  • Liver(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZNF446: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF446 Gene

Orthologs for ZNF446 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF446 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF446 33 34
  • 98.81 (n)
(Canis familiaris)
Mammalia ZNF446 33 34
  • 80.29 (n)
(Bos Taurus)
Mammalia ZNF446 33 34
  • 75.51 (n)
(Mus musculus)
Mammalia Zfp446 33 16 34
  • 69.49 (n)
(Rattus norvegicus)
Mammalia LOC102552463 33
  • 69.45 (n)
(Monodelphis domestica)
Mammalia ZNF446 34
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF446 34
  • 24 (a)
Species where no ortholog for ZNF446 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF446 Gene

Gene Tree for ZNF446 (if available)
Gene Tree for ZNF446 (if available)

Paralogs for ZNF446 Gene Pseudogenes for ZNF446 Gene

genes like me logo Genes that share paralogs with ZNF446: view

Variants for ZNF446 Gene

Sequence variations from dbSNP and Humsavar for ZNF446 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000230786 -- 58,484,643(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000430399 -- 58,475,937(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000538068 -- 58,489,220(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000583549 -- 58,484,984(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000760193 -- 58,476,534(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF446 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1116353 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833888 CNV loss 17160897
nsv952156 CNV deletion 24416366

Variation tolerance for ZNF446 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF446 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF446 Gene

Disorders for ZNF446 Gene

Additional Disease Information for ZNF446

No disorders were found for ZNF446 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF446 Gene

Publications for ZNF446 Gene

  1. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PMID: 15936718) Liu F … Liu M (Biochemical and biophysical research communications 2005) 3 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF446 Gene

Sources for ZNF446 Gene

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