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Aliases for ZNF445 Gene

Aliases for ZNF445 Gene

  • Zinc Finger Protein 445 2 3 3 5
  • Zinc Finger Protein 168 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 15 3 4
  • ZKSCAN15 3 4
  • ZNF168 3 4
  • ZSCAN47 3

External Ids for ZNF445 Gene

Previous HGNC Symbols for ZNF445 Gene

  • ZNF168

Previous GeneCards Identifiers for ZNF445 Gene

  • GC03U900303
  • GC03M044448
  • GC03M044462
  • GC03M044481

Summaries for ZNF445 Gene

GeneCards Summary for ZNF445 Gene

ZNF445 (Zinc Finger Protein 445) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZNF445 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF445 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF445 Gene

Genomics for ZNF445 Gene

GeneHancer (GH) Regulatory Elements for ZNF445 Gene

Promoters and enhancers for ZNF445 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J044509 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.3 -33.0 -33029 2.6 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 YY1 TCF12 POLR2B ZNF852 ZNF445 ZNF660 ZNF197 ZNF35 ZDHHC3 ZNF502 EI24P3
GH03J044476 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.5 528 2.3 HDGF ARID4B ZNF48 ZNF143 ATF7 REST KAT8 MXD3 CTCF MEIS2 LOC101928529 ZNF445 ZNF502 ZNF35 GC03M044441
GH03J044337 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.5 +138.6 138601 3.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LOC105377055 TCAIM ZNF660 ZNF445 ZNF852 ZNF502 SNRK-AS1 ZNF197 ZNF35 ENSG00000271941
GH03J043689 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.1 +783.3 783251 10.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ABHD5 ANO10 ZNF445 ZNF660 ZNF35 ZNF197 ZNF852 ENSG00000261786 PIR40588 GC03M043165
GH03J044974 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 16.6 -498.2 -498153 3.6 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 SP3 SP5 ZHX2 EXOSC7 ZDHHC3 ZNF445 RN7SL145P CLEC3B ZNF502 ZKSCAN7 ZNF852 RNU5B-3P KIAA1143
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF445 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF445 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • c-Fos

Genomic Locations for ZNF445 Gene

Genomic Locations for ZNF445 Gene
45,951 bases
Minus strand
37,901 bases
Minus strand

Genomic View for ZNF445 Gene

Genes around ZNF445 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF445 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF445 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF445 Gene

Proteins for ZNF445 Gene

  • Protein details for ZNF445 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 445
    Protein Accession:
    Secondary Accessions:
    • Q3MJD1

    Protein attributes for ZNF445 Gene

    1031 amino acids
    Molecular mass:
    118963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF445 Gene

Post-translational modifications for ZNF445 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF445 Gene

Domains & Families for ZNF445 Gene

Gene Families for ZNF445 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF445 Gene

Suggested Antigen Peptide Sequences for ZNF445 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF445: view

Function for ZNF445 Gene

Molecular function for ZNF445 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF445 Gene

Gene Ontology (GO) - Molecular Function for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF445: view
genes like me logo Genes that share phenotypes with ZNF445: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF445

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF445 Gene

Localization for ZNF445 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF445 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF445 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with ZNF445: view

Pathways & Interactions for ZNF445 Gene

SuperPathways for ZNF445 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF445: view

Pathways by source for ZNF445 Gene

2 Reactome pathways for ZNF445 Gene

Gene Ontology (GO) - Biological Process for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF445: view

No data available for SIGNOR curated interactions for ZNF445 Gene

Drugs & Compounds for ZNF445 Gene

No Compound Related Data Available

Transcripts for ZNF445 Gene

mRNA/cDNA for ZNF445 Gene

(7) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF445 Gene

Zinc finger protein 445:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF445

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF445 Gene

No ASD Table

Relevant External Links for ZNF445 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF445 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF445 Gene

Protein differential expression in normal tissues from HIPED for ZNF445 Gene

This gene is overexpressed in Urine (24.9), Vitreous humor (23.4), and Heart (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF445 Gene

Protein tissue co-expression partners for ZNF445 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF445 Gene:


SOURCE GeneReport for Unigene cluster for ZNF445 Gene:


Evidence on tissue expression from TISSUES for ZNF445 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF445: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF445 Gene

Orthologs for ZNF445 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF445 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF445 34 33
  • 88.08 (n)
(Canis familiaris)
Mammalia ZNF445 34 33
  • 85.54 (n)
(Bos Taurus)
Mammalia ZNF445 34 33
  • 83.61 (n)
(Rattus norvegicus)
Mammalia Zfp445 33
  • 75.95 (n)
(Mus musculus)
Mammalia Zfp445 16 34 33
  • 75.37 (n)
(Monodelphis domestica)
Mammalia ZNF445 34
  • 37 (a)
Species where no ortholog for ZNF445 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF445 Gene

Gene Tree for ZNF445 (if available)
Gene Tree for ZNF445 (if available)
Evolutionary constrained regions (ECRs) for ZNF445: view image

Paralogs for ZNF445 Gene

genes like me logo Genes that share paralogs with ZNF445: view

No data available for Paralogs for ZNF445 Gene

Variants for ZNF445 Gene

Sequence variations from dbSNP and Humsavar for ZNF445 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000138890 -- 44,439,464(-) T/C downstream_transcript_variant
rs1000146830 -- 44,475,600(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000248826 -- 44,444,126(-) C/A 3_prime_UTR_variant
rs1000297945 -- 44,444,376(-) G/A 3_prime_UTR_variant
rs1000327244 -- 44,457,549(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF445 Gene

Variant ID Type Subtype PubMed ID
esv3568716 CNV loss 25503493

Variation tolerance for ZNF445 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF445 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF445 Gene

Disorders for ZNF445 Gene

Additional Disease Information for ZNF445

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF445 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF445 Gene

Publications for ZNF445 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PMID: 7814019) Calabrò V … Lania L (Human genetics 1995) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for ZNF445 Gene

Sources for ZNF445 Gene

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