This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different iso... See more...

Aliases for ZNF444 Gene

Aliases for ZNF444 Gene

  • Zinc Finger Protein 444 2 3 4 5
  • ZSCAN17 2 3 4
  • EZF2 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 17 3 4
  • Endothelial Zinc Finger Protein 2 3 4
  • EZF-2 3 4
  • FLJ11137 2
  • ZNF444 5

External Ids for ZNF444 Gene

Previous GeneCards Identifiers for ZNF444 Gene

  • GC19P061328
  • GC19P061344
  • GC19P056652
  • GC19P052962

Summaries for ZNF444 Gene

Entrez Gene Summary for ZNF444 Gene

  • This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF444 Gene

ZNF444 (Zinc Finger Protein 444) is a Protein Coding gene. Diseases associated with ZNF444 include Myoepithelial Carcinoma and Vulvar Sarcoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot Summary for ZNF444 Gene

  • Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.

Additional gene information for ZNF444 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF444 Gene

Genomics for ZNF444 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF444 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J056139 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.4 +9.8 9814 5.2 CEBPG SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 RFX1 SIX5 ZNF444 ISOC2 HSALNG0127727 GALP
GH19J056131 Enhancer 0.8 ENCODE CraniofacialAtlas dbSUPER 600.7 -0.1 -120 1.3 CEBPA CEBPB TEAD1 TEAD3 CEBPG ZNF444 ENSG00000279959 ZNF787
GH19J056133 Enhancer 0.7 ENCODE dbSUPER 600.7 +1.5 1548 0.2 PKNOX1 TCF12 HDGF TCF7L2 EBF1 SMARCA4 TARDBP BHLHE40 SP7 ZNF444 HSALNG0127727 GALP
GH19J056136 Enhancer 0.6 dbSUPER 600.7 +2.0 1980 0.5 FOXA1 PKNOX1 HDGF BCOR GATA3 STAT1 TCF7L2 TARDBP BHLHE40 ZMYM3 ZNF444 HSALNG0127727 GALP
GH19J056134 Enhancer 0.2 dbSUPER 600.7 +0.9 928 0.4 ZNF444 HSALNG0127727 GALP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF444 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF444

Top Transcription factor binding sites by QIAGEN in the ZNF444 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • STAT1
  • STAT1alpha
  • Tal-1beta

Genomic Locations for ZNF444 Gene

Genomic Locations for ZNF444 Gene
chr19:56,132,509-56,160,893
(GRCh38/hg38)
Size:
28,385 bases
Orientation:
Plus strand
chr19:56,643,968-56,672,262
(GRCh37/hg19)
Size:
28,295 bases
Orientation:
Plus strand

Genomic View for ZNF444 Gene

Genes around ZNF444 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF444 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF444 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF444 Gene

Proteins for ZNF444 Gene

  • Protein details for ZNF444 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y2-ZN444_HUMAN
    Recommended name:
    Zinc finger protein 444
    Protein Accession:
    Q8N0Y2
    Secondary Accessions:
    • Q8TEQ9
    • Q8WU35
    • Q9NUU1

    Protein attributes for ZNF444 Gene

    Size:
    327 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84889.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF444 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF444 Gene

Post-translational modifications for ZNF444 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF444 Gene

Domains & Families for ZNF444 Gene

Gene Families for ZNF444 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF444 Gene

InterPro:
Blocks:
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF444 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and SCAN domain-containing protein 17 (ZN444_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N0Y2

UniProtKB/Swiss-Prot:

ZN444_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF444: view

Function for ZNF444 Gene

Molecular function for ZNF444 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.

Phenotypes From GWAS Catalog for ZNF444 Gene

Gene Ontology (GO) - Molecular Function for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF444: view
genes like me logo Genes that share phenotypes with ZNF444: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF444

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF444 Gene

Localization for ZNF444 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF444 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF444 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF444: view

Pathways & Interactions for ZNF444 Gene

PathCards logo

SuperPathways for ZNF444 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF444: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF444 Gene

Drugs & Compounds for ZNF444 Gene

No Compound Related Data Available

Transcripts for ZNF444 Gene

mRNA/cDNA for ZNF444 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF444

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - -
SP13: -
SP14:
SP15:

ExUns: 11b · 11c · 11d ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZNF444 Gene

GeneLoc Exon Structure for
ZNF444

Expression for ZNF444 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF444 Gene

Protein differential expression in normal tissues from HIPED for ZNF444 Gene

This gene is overexpressed in Fetal ovary (45.0), CD8 Tcells (13.7), and Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF444 Gene



Protein tissue co-expression partners for ZNF444 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF444

SOURCE GeneReport for Unigene cluster for ZNF444 Gene:

Hs.24545

Evidence on tissue expression from TISSUES for ZNF444 Gene

  • Lung(4.3)
  • Liver(4.2)
  • Spleen(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZNF444: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF444 Gene

Orthologs for ZNF444 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF444 30 31
  • 99.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF444 30 31
  • 84.86 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp444 30 17 31
  • 84.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF444 30 31
  • 84.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp444 30
  • 83.67 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 43 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
-- 31
  • 33 (a)
OneToMany
-- 31
  • 31 (a)
OneToMany
-- 31
  • 29 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 13 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
-- 31
  • 34 (a)
OneToMany
-- 31
  • 33 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
-- 31
  • 28 (a)
OneToMany
-- 31
  • 28 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
-- 31
  • 24 (a)
OneToMany
-- 31
  • 24 (a)
OneToMany
-- 31
  • 24 (a)
OneToMany
-- 31
  • 24 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
-- 31
  • 21 (a)
OneToMany
-- 31
  • 21 (a)
OneToMany
-- 31
  • 21 (a)
OneToMany
-- 31
  • 20 (a)
OneToMany
-- 31
  • 19 (a)
OneToMany
-- 31
  • 19 (a)
OneToMany
-- 31
  • 19 (a)
OneToMany
-- 31
  • 18 (a)
OneToMany
-- 31
  • 18 (a)
OneToMany
-- 31
  • 17 (a)
OneToMany
-- 31
  • 14 (a)
OneToMany
-- 31
  • 14 (a)
OneToMany
-- 31
  • 13 (a)
OneToMany
-- 31
  • 12 (a)
OneToMany
-- 31
  • 9 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta l(3)neo38 31
  • 11 (a)
ManyToMany
CG7368 31
  • 8 (a)
ManyToMany
Species where no ortholog for ZNF444 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF444 Gene

ENSEMBL:
Gene Tree for ZNF444 (if available)
TreeFam:
Gene Tree for ZNF444 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF444: view image

Paralogs for ZNF444 Gene

(37) SIMAP similar genes for ZNF444 Gene using alignment to 7 proteins:

  • ZN444_HUMAN
  • K7EJ91_HUMAN
  • K7EJH4_HUMAN
  • K7EK55_HUMAN
  • K7ELZ3_HUMAN
  • K7EMV5_HUMAN
  • K7ESL2_HUMAN

Pseudogenes.org Pseudogenes for ZNF444 Gene

genes like me logo Genes that share paralogs with ZNF444: view

Variants for ZNF444 Gene

Additional dbSNP identifiers (rs#s) for ZNF444 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF444 Gene

Variant ID Type Subtype PubMed ID
dgv206n21 CNV loss 19592680
dgv207n21 CNV loss 19592680
dgv3681n100 CNV gain 25217958
dgv545e201 CNV deletion 23290073
esv2719020 CNV deletion 23290073
esv2719021 CNV deletion 23290073
esv2719024 CNV deletion 23290073
esv3583591 CNV loss 25503493
nsv1057820 CNV gain 25217958
nsv1143928 CNV deletion 24896259
nsv528361 CNV loss 19592680
nsv580354 CNV gain 21841781

Variation tolerance for ZNF444 Gene

Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF444 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF444

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF444 Gene

Disorders for ZNF444 Gene

MalaCards: The human disease database

(13) MalaCards diseases for ZNF444 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myoepithelial carcinoma
  • malignant myoepithelioma
vulvar sarcoma
  • sarcoma of vulva
sweat gland benign neoplasm
  • neoplasm of sweat gland
extraosseous chondrosarcoma
  • extraskeletal myxoid chondrosarcoma
parachordoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF444: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF444 Gene

Publications for ZNF444 Gene

  1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PMID: 11978792) Adachi H … Tsujimoto M (The Journal of biological chemistry 2002) 2 3 4
  2. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PMID: 19760602) Brandal P … Heim S (Genes, chromosomes & cancer 2009) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF444 Gene

Sources for ZNF444 Gene