Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF444 Gene

Aliases for ZNF444 Gene

  • Zinc Finger Protein 444 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 17 3 4
  • Endothelial Zinc Finger Protein 2 3 4
  • ZSCAN17 3 4
  • EZF-2 3 4
  • EZF2 3 4

External Ids for ZNF444 Gene

Previous GeneCards Identifiers for ZNF444 Gene

  • GC19P061328
  • GC19P061344
  • GC19P056652
  • GC19P052962

Summaries for ZNF444 Gene

Entrez Gene Summary for ZNF444 Gene

  • This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF444 Gene

ZNF444 (Zinc Finger Protein 444) is a Protein Coding gene. Diseases associated with ZNF444 include Chondrosarcoma, Extraskeletal Myxoid. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot for ZNF444 Gene

  • Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

Additional gene information for ZNF444 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF444 Gene

Genomics for ZNF444 Gene

GeneHancer (GH) Regulatory Elements for ZNF444 Gene

Promoters and enhancers for ZNF444 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I056139 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.4 +9.7 9724 5.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 ZNF444 ISOC2 ENSG00000279794 GC19M056096 GC19P056014
GH19I056133 Enhancer 1 Ensembl ENCODE dbSUPER 550.8 +1.7 1677 0.6 HDGF BCOR STAT1 PKNOX1 ZMYM3 EBF1 GATA3 TARDBP ZFP36 TCF7L2 ZNF444 ENSG00000279794 GC19M056096 GC19P056014
GH19I056131 Enhancer 0.9 Ensembl ENCODE dbSUPER 550.8 -0.2 -210 1.3 TEAD1 CEBPA CEBPB CEBPG TEAD3 ZNF444 ENSG00000279959 GC19M056096 GC19P056014
GH19I056134 Enhancer 0.2 dbSUPER 550.8 +0.8 838 0.4 ZNF444 ENSG00000279794 GC19M056096 GC19P056014
GH19I055579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 -551.4 -551399 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF579 FIZ1 ZNF471 ZNF582 ZNF542P ZNF470 ENSG00000269696 ZFP28 ZNF583 ZNF582-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF444 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF444 gene promoter:

Genomic Locations for ZNF444 Gene

Genomic Locations for ZNF444 Gene
chr19:56,132,599-56,160,893
(GRCh38/hg38)
Size:
28,295 bases
Orientation:
Plus strand
chr19:56,643,968-56,672,262
(GRCh37/hg19)

Genomic View for ZNF444 Gene

Genes around ZNF444 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF444 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF444 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF444 Gene

Proteins for ZNF444 Gene

  • Protein details for ZNF444 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y2-ZN444_HUMAN
    Recommended name:
    Zinc finger protein 444
    Protein Accession:
    Q8N0Y2
    Secondary Accessions:
    • Q8TEQ9
    • Q8WU35
    • Q9NUU1

    Protein attributes for ZNF444 Gene

    Size:
    327 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84889.1; Type=Frameshift; Positions=99; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF444 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF444 Gene

Post-translational modifications for ZNF444 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF444 Gene

Domains & Families for ZNF444 Gene

Gene Families for ZNF444 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF444 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y2

UniProtKB/Swiss-Prot:

ZN444_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF444: view

Function for ZNF444 Gene

Molecular function for ZNF444 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

Phenotypes From GWAS Catalog for ZNF444 Gene

Gene Ontology (GO) - Molecular Function for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF444: view
genes like me logo Genes that share phenotypes with ZNF444: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF444 Gene

Localization for ZNF444 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF444 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF444 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with ZNF444: view

Pathways & Interactions for ZNF444 Gene

SuperPathways for ZNF444 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF444: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF444 Gene

Drugs & Compounds for ZNF444 Gene

No Compound Related Data Available

Transcripts for ZNF444 Gene

Unigene Clusters for ZNF444 Gene

Zinc finger protein 444:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - -
SP13: -
SP14:
SP15:

ExUns: 11b · 11c · 11d ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZNF444 Gene

GeneLoc Exon Structure for
ZNF444
ECgene alternative splicing isoforms for
ZNF444

Expression for ZNF444 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF444 Gene

Protein differential expression in normal tissues from HIPED for ZNF444 Gene

This gene is overexpressed in Fetal ovary (45.0), CD8 Tcells (13.7), and Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF444 Gene



Protein tissue co-expression partners for ZNF444 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF444 Gene:

ZNF444

SOURCE GeneReport for Unigene cluster for ZNF444 Gene:

Hs.24545

Evidence on tissue expression from TISSUES for ZNF444 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with ZNF444: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF444 Gene

Orthologs for ZNF444 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF444 33 34
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia ZNF444 33 34
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Zfp444 33 16 34
  • 84.3 (n)
dog
(Canis familiaris)
Mammalia ZNF444 33 34
  • 84.29 (n)
rat
(Rattus norvegicus)
Mammalia Zfp444 33
  • 83.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 13 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 34 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
-- 34
  • 17 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
-- 34
  • 13 (a)
OneToMany
-- 34
  • 12 (a)
OneToMany
-- 34
  • 9 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo38 34
  • 11 (a)
ManyToMany
CG7368 34
  • 8 (a)
ManyToMany
Species where no ortholog for ZNF444 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF444 Gene

ENSEMBL:
Gene Tree for ZNF444 (if available)
TreeFam:
Gene Tree for ZNF444 (if available)

Paralogs for ZNF444 Gene

Variants for ZNF444 Gene

Sequence variations from dbSNP and Humsavar for ZNF444 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000018935 -- 56,160,709(+) GGGGG/GGGG 3_prime_UTR_variant
rs1000155870 -- 56,160,488(+) C/G 3_prime_UTR_variant
rs1000228577 -- 56,152,622(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000307036 -- 56,159,380(+) C/T intron_variant
rs1000317050 -- 56,156,689(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF444 Gene

Variant ID Type Subtype PubMed ID
nsv580354 CNV gain 21841781
nsv528361 CNV loss 19592680
nsv1143928 CNV deletion 24896259
nsv1057820 CNV gain 25217958
esv3583591 CNV loss 25503493
esv2719024 CNV deletion 23290073
esv2719021 CNV deletion 23290073
esv2719020 CNV deletion 23290073
dgv545e201 CNV deletion 23290073
dgv3681n100 CNV gain 25217958
dgv207n21 CNV loss 19592680
dgv206n21 CNV loss 19592680

Variation tolerance for ZNF444 Gene

Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF444 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF444

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF444 Gene

Disorders for ZNF444 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF444 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • emc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF444

genes like me logo Genes that share disorders with ZNF444: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF444 Gene

Publications for ZNF444 Gene

  1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PMID: 11978792) Adachi H … Tsujimoto M (The Journal of biological chemistry 2002) 2 3 4 58
  2. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PMID: 19760602) Brandal P … Heim S (Genes, chromosomes & cancer 2009) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF444 Gene

Sources for ZNF444 Gene

Content
Loading form....