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Aliases for ZNF443 Gene

Aliases for ZNF443 Gene

  • Zinc Finger Protein 443 2 3 4 5
  • Krueppel-Type Zinc Finger Protein ZK1 3 4
  • Kruppel-Type Zinc Finger (C2H2) 3
  • ZK1 3

External Ids for ZNF443 Gene

Previous GeneCards Identifiers for ZNF443 Gene

  • GC19M012385
  • GC19M012290
  • GC19M012120
  • GC19M012540

Summaries for ZNF443 Gene

Entrez Gene Summary for ZNF443 Gene

  • Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF443 Gene

ZNF443 (Zinc Finger Protein 443) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF799.

UniProtKB/Swiss-Prot for ZNF443 Gene

Additional gene information for ZNF443 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF443 Gene

Genomics for ZNF443 Gene

GeneHancer (GH) Regulatory Elements for ZNF443 Gene

Promoters and enhancers for ZNF443 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012439 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 625.3 +16.7 16721 2.8 ZFX SP1 ELF3 ZNF148 NKRF ZSCAN21 FOS AHR SP7 POLR2A ZNF443 ENSG00000268870 ZNF44 ZNF136 ZNF20 ZNF627 ZNF709 ZNF564 ZNF763 ENSG00000242615
GH19J012430 Promoter 0.5 EPDnew 600.3 +27.2 27195 0.1 ZNF443 ENSG00000268870 ZNF799
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -331.8 -331777 16 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 IER2 CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 MRI1
GH19J012609 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.8 -154.7 -154654 5.2 SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A MLLT1 CEBPG RERE ZNF490 ZNF791 PIR37932 ZNF136 ZNF44 ZNF442 ZNF844 ZNF20 ZNF564 ZNF700
GH19J012918 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.8 -462.3 -462349 2.2 ZFX SP1 NKRF MLLT1 ZNF121 POLR2A ZNF384 ZNF687 ZSCAN21 ZBTB7A MIR5695 SYCE2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF20 ZNF763 ZNF564 ZNF700
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF443 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF443 Gene

Genomic Locations for ZNF443 Gene
27,816 bases
Minus strand
11,407 bases
Minus strand

Genomic View for ZNF443 Gene

Genes around ZNF443 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF443 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF443 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF443 Gene

Proteins for ZNF443 Gene

  • Protein details for ZNF443 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 443
    Protein Accession:

    Protein attributes for ZNF443 Gene

    671 amino acids
    Molecular mass:
    77516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF443 Gene

Post-translational modifications for ZNF443 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF443 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF443 Gene

Domains & Families for ZNF443 Gene

Gene Families for ZNF443 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF443 Gene

Suggested Antigen Peptide Sequences for ZNF443 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59243, highly similar to Zinc finger protein 443 (B4DS18_HUMAN)
  • Krueppel-type zinc finger protein ZK1 (ZN443_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF443: view

Function for ZNF443 Gene

Molecular function for ZNF443 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Induced following exposure to ionizing radiation.

Phenotypes From GWAS Catalog for ZNF443 Gene

Gene Ontology (GO) - Molecular Function for ZNF443 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF443: view
genes like me logo Genes that share phenotypes with ZNF443: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF443

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF443 Gene

Localization for ZNF443 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF443 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF443 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF443 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF443: view

Pathways & Interactions for ZNF443 Gene

genes like me logo Genes that share pathways with ZNF443: view

Pathways by source for ZNF443 Gene

2 Reactome pathways for ZNF443 Gene
1 KEGG pathway for ZNF443 Gene

Interacting Proteins for ZNF443 Gene

Gene Ontology (GO) - Biological Process for ZNF443 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006915 apoptotic process TAS 9731181
genes like me logo Genes that share ontologies with ZNF443: view

No data available for SIGNOR curated interactions for ZNF443 Gene

Drugs & Compounds for ZNF443 Gene

No Compound Related Data Available

Transcripts for ZNF443 Gene

mRNA/cDNA for ZNF443 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF443 Gene

Zinc finger protein 443:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF443

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF443 Gene

ExUns: 1 ^ 2 ^ 3a · 3b

Relevant External Links for ZNF443 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF443 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF443 Gene

Protein differential expression in normal tissues from HIPED for ZNF443 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF443 Gene

Protein tissue co-expression partners for ZNF443 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF443 Gene:


SOURCE GeneReport for Unigene cluster for ZNF443 Gene:

genes like me logo Genes that share expression patterns with ZNF443: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF443 Gene

Orthologs for ZNF443 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF443 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF443 35 34
  • 98.96 (n)
(Mus musculus)
Mammalia Zfp709 17 34
  • 66.12 (n)
(Rattus norvegicus)
Mammalia Zfp709 34
  • 65.27 (n)
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
Species where no ortholog for ZNF443 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF443 Gene

Gene Tree for ZNF443 (if available)
Gene Tree for ZNF443 (if available)
Evolutionary constrained regions (ECRs) for ZNF443: view image

Paralogs for ZNF443 Gene

(495) SIMAP similar genes for ZNF443 Gene using alignment to 2 proteins:

  • ZN443_HUMAN
genes like me logo Genes that share paralogs with ZNF443: view

Variants for ZNF443 Gene

Sequence variations from dbSNP and Humsavar for ZNF443 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000182615 -- 12,429,840(-) A/T 3_prime_UTR_variant
rs1000230849 -- 12,430,087(-) C/T 3_prime_UTR_variant
rs1000243704 -- 12,435,673(-) G/A intron_variant
rs1000358992 -- 12,435,445(-) G/C intron_variant
rs1000424547 -- 12,440,764(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF443 Gene

Variant ID Type Subtype PubMed ID
dgv3431n100 CNV loss 25217958
dgv3432n100 CNV gain 25217958
dgv3433n100 CNV gain 25217958
dgv3434n100 CNV gain 25217958
dgv3435n100 CNV gain 25217958
esv21983 CNV gain 19812545
esv2718192 CNV deletion 23290073
esv2718194 CNV deletion 23290073
esv2758745 CNV gain 17122850
esv2760528 CNV gain 21179565
esv2762025 CNV loss 21179565
esv3574319 CNV gain 25503493
esv3643700 CNV loss 21293372
esv3643701 CNV gain 21293372
esv3893165 CNV loss 25118596
nsv1063081 CNV gain 25217958
nsv1063391 CNV gain 25217958
nsv1071911 CNV deletion 25765185
nsv1140383 CNV deletion 24896259
nsv442453 CNV gain 18776908
nsv578625 CNV gain 21841781
nsv960793 CNV duplication 23825009

Variation tolerance for ZNF443 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.27; 96.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF443 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF443 Gene

Disorders for ZNF443 Gene

Additional Disease Information for ZNF443

No disorders were found for ZNF443 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF443 Gene

Publications for ZNF443 Gene

  1. ZK1, a novel Krüppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. (PMID: 9731181) Katoh O … Watanabe H (Biochemical and biophysical research communications 1998) 2 3 4 23 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PMID: 16147992) Miles RR … Elenitoba-Johnson KS (Molecular & cellular proteomics : MCP 2005) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for ZNF443 Gene

Sources for ZNF443 Gene

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