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Aliases for ZNF442 Gene

Aliases for ZNF442 Gene

  • Zinc Finger Protein 442 2 3 4 5

External Ids for ZNF442 Gene

Previous GeneCards Identifiers for ZNF442 Gene

  • GC19M012305
  • GC19M012321
  • GC19M012119
  • GC19M012460
  • GC19M012035
  • GC19M012349

Summaries for ZNF442 Gene

GeneCards Summary for ZNF442 Gene

ZNF442 (Zinc Finger Protein 442) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF443.

UniProtKB/Swiss-Prot for ZNF442 Gene

Additional gene information for ZNF442 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF442 Gene

Genomics for ZNF442 Gene

GeneHancer (GH) Regulatory Elements for ZNF442 Gene

Promoters and enhancers for ZNF442 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012364 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.5 549 2.5 SP1 ZFX CTCF ELF3 NKRF POLR2A AHR TRIM24 HNF1A ZNF644 ZNF442 ZNF563 ZNF491 ZNF441 ZNF625 ZNF44 ZNF625-ZNF20 RPS6P25 DHPS ZNF788P
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.8 -423.3 -423313 16 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 IER2 CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 MRI1
GH19J013148 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 54.8 -787.4 -787407 10.8 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 MNT SIX5 ZNF148 NKRF STX10 ENSG00000267598 IER2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS RFX1
GH19J012609 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 51.8 -246.2 -246190 5.2 SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A MLLT1 CEBPG RERE ZNF490 ZNF791 PIR37932 ZNF136 ZNF44 ZNF442 ZNF844 ZNF20 ZNF564 ZNF700
GH19J013115 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.9 -753.0 -752951 7.7 MTA3 ZFX SP1 CC2D1A ELF3 ZKSCAN8 MNT SIX5 CBFA2T2 ZNF148 TRMT1 NACC1 ZNF791 ZNF136 CCDC130 MRI1 WDR83OS ZNF44 ZNF442 ZNF564
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF442 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF442 gene promoter:
  • HTF
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for ZNF442 Gene

Genomic Locations for ZNF442 Gene
chr19:12,345,944-12,365,985
(GRCh38/hg38)
Size:
20,042 bases
Orientation:
Minus strand
chr19:12,460,185-12,476,719
(GRCh37/hg19)
Size:
16,535 bases
Orientation:
Minus strand

Genomic View for ZNF442 Gene

Genes around ZNF442 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF442 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF442 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF442 Gene

Proteins for ZNF442 Gene

  • Protein details for ZNF442 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7R0-ZN442_HUMAN
    Recommended name:
    Zinc finger protein 442
    Protein Accession:
    Q9H7R0
    Secondary Accessions:
    • B4DJ48

    Protein attributes for ZNF442 Gene

    Size:
    627 amino acids
    Molecular mass:
    72863 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF442 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF442 Gene

Post-translational modifications for ZNF442 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF442 Gene

Domains & Families for ZNF442 Gene

Gene Families for ZNF442 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF442 Gene

Suggested Antigen Peptide Sequences for ZNF442 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58386, highly similar to Zinc finger protein 442 (B4DJ48_HUMAN)
  • Zinc finger protein 442 (ZN442_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H7R0

UniProtKB/Swiss-Prot:

ZN442_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF442: view

Function for ZNF442 Gene

Molecular function for ZNF442 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF442 Gene

Gene Ontology (GO) - Molecular Function for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF442: view
genes like me logo Genes that share phenotypes with ZNF442: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF442 - Now 50% OFF >
  • * ZNF442 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF442 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF442 Gene

Localization for ZNF442 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF442 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF442 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF442: view

Pathways & Interactions for ZNF442 Gene

genes like me logo Genes that share pathways with ZNF442: view

Pathways by source for ZNF442 Gene

2 Reactome pathways for ZNF442 Gene
1 KEGG pathway for ZNF442 Gene

Interacting Proteins for ZNF442 Gene

Gene Ontology (GO) - Biological Process for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF442: view

No data available for SIGNOR curated interactions for ZNF442 Gene

Drugs & Compounds for ZNF442 Gene

No Compound Related Data Available

Transcripts for ZNF442 Gene

mRNA/cDNA for ZNF442 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF442 Gene

Zinc finger protein 442:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF442 - Now 50% OFF >
  • * ZNF442 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF442 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF442 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for ZNF442 Gene

GeneLoc Exon Structure for
ZNF442
ECgene alternative splicing isoforms for
ZNF442

Expression for ZNF442 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF442 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF442 Gene:

ZNF442

SOURCE GeneReport for Unigene cluster for ZNF442 Gene:

Hs.253193

Evidence on tissue expression from TISSUES for ZNF442 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF442: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF442 Gene

Orthologs for ZNF442 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF442 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF442 35 34
  • 98.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909622 34
  • 64.24 (n)
mouse
(Mus musculus)
Mammalia Gm14325 34
  • 63.1 (n)
Zfp971 17
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF442 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF442 Gene

ENSEMBL:
Gene Tree for ZNF442 (if available)
TreeFam:
Gene Tree for ZNF442 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF442: view image

Paralogs for ZNF442 Gene

(507) SIMAP similar genes for ZNF442 Gene using alignment to 3 proteins:

  • ZN442_HUMAN
  • B4DJ48_HUMAN
  • C9JC15_HUMAN

Pseudogenes.org Pseudogenes for ZNF442 Gene

genes like me logo Genes that share paralogs with ZNF442: view

Variants for ZNF442 Gene

Sequence variations from dbSNP and Humsavar for ZNF442 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs10414971 A colorectal cancer sample 12,351,131(-) G/A coding_sequence_variant, missense_variant
rs757755988 A colorectal cancer sample 12,350,857(-) C/G/T coding_sequence_variant, missense_variant
rs1000029896 -- 12,361,843(-) C/A/T intron_variant
rs1000045622 -- 12,373,533(-) C/T upstream_transcript_variant
rs1000443347 -- 12,361,244(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF442 Gene

Variant ID Type Subtype PubMed ID
esv1086965 CNV deletion 17803354
esv2718192 CNV deletion 23290073
nsv961181 CNV duplication 23825009

Variation tolerance for ZNF442 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF442 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF442

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF442 Gene

Disorders for ZNF442 Gene

Additional Disease Information for ZNF442

No disorders were found for ZNF442 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF442 Gene

Publications for ZNF442 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF442 Gene

Sources for ZNF442 Gene

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