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Aliases for ZNF442 Gene

Aliases for ZNF442 Gene

  • Zinc Finger Protein 442 2 3 5

External Ids for ZNF442 Gene

Previous GeneCards Identifiers for ZNF442 Gene

  • GC19M012305
  • GC19M012321
  • GC19M012119
  • GC19M012460
  • GC19M012035

Summaries for ZNF442 Gene

GeneCards Summary for ZNF442 Gene

ZNF442 (Zinc Finger Protein 442) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF799.

UniProtKB/Swiss-Prot for ZNF442 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF442 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF442 Gene

Genomics for ZNF442 Gene

GeneHancer (GH) Regulatory Elements for ZNF442 Gene

Promoters and enhancers for ZNF442 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012364 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 449 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B GLIS2 ZNF143 ZNF442 ZNF44 ZNF625-ZNF20 ZNF788 PIR44087
GH19I011531 Enhancer 1.4 FANTOM5 Ensembl ENCODE 121.5 +833.5 833547 1.6 PKNOX1 ATF1 ZNF493 ZFP64 ZNF213 FOS ZNF202 ZC3H11A REST ZNF623 ZNF627 ILF3 ZNF136 ZNF442 ZNF844 ZNF625 KRI1 ZNF44 ZNF441 ZNF709
GH19I012983 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 94.1 -618.8 -618817 3.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF136 ZNF625 ZNF442 ZNF844 CCDC130 ZNF564 ZNF799 WDR83OS ZNF788 ZNF709
GH19I012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 58.4 -423.3 -423313 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 JUNB CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 WDR83OS TRMT1 ZNF700 TRIR
GH19I013115 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 56.7 -753.0 -752951 7.7 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 TRMT1 NACC1 ZNF791 ZNF136 ZNF442 CCDC130 MRI1 ZNF564 WDR83OS ZNF44
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF442 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF442 gene promoter:

Genomic Locations for ZNF442 Gene

Genomic Locations for ZNF442 Gene
20,037 bases
Minus strand

Genomic View for ZNF442 Gene

Genes around ZNF442 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF442 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF442 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF442 Gene

Proteins for ZNF442 Gene

  • Protein details for ZNF442 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 442
    Protein Accession:
    Secondary Accessions:
    • B4DJ48

    Protein attributes for ZNF442 Gene

    627 amino acids
    Molecular mass:
    72863 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF442 Gene


neXtProt entry for ZNF442 Gene

Post-translational modifications for ZNF442 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF442 Gene

No data available for DME Specific Peptides for ZNF442 Gene

Domains & Families for ZNF442 Gene

Gene Families for ZNF442 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF442 Gene

Suggested Antigen Peptide Sequences for ZNF442 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF442: view

Function for ZNF442 Gene

Molecular function for ZNF442 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF442 Gene

Gene Ontology (GO) - Molecular Function for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF442: view
genes like me logo Genes that share phenotypes with ZNF442: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF442 Gene

Localization for ZNF442 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF442 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF442 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF442: view

Pathways & Interactions for ZNF442 Gene

SuperPathways for ZNF442 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF442: view

Pathways by source for ZNF442 Gene

2 Reactome pathways for ZNF442 Gene

Interacting Proteins for ZNF442 Gene

Gene Ontology (GO) - Biological Process for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF442: view

No data available for SIGNOR curated interactions for ZNF442 Gene

Drugs & Compounds for ZNF442 Gene

No Compound Related Data Available

Transcripts for ZNF442 Gene

mRNA/cDNA for ZNF442 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF442 Gene

Zinc finger protein 442:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF442 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - - -
SP2: - -

Relevant External Links for ZNF442 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF442 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF442 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF442 Gene:


SOURCE GeneReport for Unigene cluster for ZNF442 Gene:


Evidence on tissue expression from TISSUES for ZNF442 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF442: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF442 Gene

Orthologs for ZNF442 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF442 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF442 33 34
  • 98.94 (n)
(Rattus norvegicus)
Mammalia LOC100909622 33
  • 64.24 (n)
(Mus musculus)
Mammalia Gm14325 33
  • 63.1 (n)
Zfp971 16
(Bos Taurus)
Mammalia -- 34
  • 50 (a)
Species where no ortholog for ZNF442 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF442 Gene

Gene Tree for ZNF442 (if available)
Gene Tree for ZNF442 (if available)

Paralogs for ZNF442 Gene

(507) SIMAP similar genes for ZNF442 Gene using alignment to 3 proteins: Pseudogenes for ZNF442 Gene

genes like me logo Genes that share paralogs with ZNF442: view

Variants for ZNF442 Gene

Sequence variations from dbSNP and Humsavar for ZNF442 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs10414971 A colorectal cancer sample 12,351,131(-) G/A coding_sequence_variant, missense_variant
rs757755988 A colorectal cancer sample 12,350,857(-) C/G/T coding_sequence_variant, missense_variant
rs1000029896 -- 12,361,843(-) C/T intron_variant
rs1000045622 -- 12,373,533(-) C/T upstream_transcript_variant
rs1000443347 -- 12,361,244(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF442 Gene

Variant ID Type Subtype PubMed ID
esv1086965 CNV deletion 17803354
esv2718192 CNV deletion 23290073
nsv961181 CNV duplication 23825009

Variation tolerance for ZNF442 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF442 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF442 Gene

Disorders for ZNF442 Gene

Additional Disease Information for ZNF442

No disorders were found for ZNF442 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF442 Gene

Publications for ZNF442 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF442 Gene

Sources for ZNF442 Gene

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