Aliases for ZNF441 Gene

Aliases for ZNF441 Gene

  • Zinc Finger Protein 441 2 3 4 5

External Ids for ZNF441 Gene

Previous GeneCards Identifiers for ZNF441 Gene

  • GC19P011723
  • GC19P011738
  • GC19P011659
  • GC19P011878
  • GC19P011452

Summaries for ZNF441 Gene

GeneCards Summary for ZNF441 Gene

ZNF441 (Zinc Finger Protein 441) is a Protein Coding gene. Diseases associated with ZNF441 include Endocervical Carcinoma and Endocervical Adenocarcinoma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF799.

UniProtKB/Swiss-Prot Summary for ZNF441 Gene

Additional gene information for ZNF441 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF441 Gene

Genomics for ZNF441 Gene

GeneHancer (GH) Regulatory Elements for ZNF441 Gene

Promoters and enhancers for ZNF441 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011766 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 508.3 +0.5 501 2.6 ZBTB40 SIN3A NRF1 POLR2G SP1 NCOR1 GTF2E2 ZIC2 POLR2A ZBTB11 ZNF441 ZNF136 ZNF763 ZNF20 ZNF44 ZNF627 ZNF439 ZNF799 TRIR ZNF564
GH19J011343 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 32.5 -421.3 -421254 5 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 POLR2G USF1 SP1 NCOR1 CCDC159 RAB3D lnc-EPOR-1 TMEM205 piR-44752 piR-50073 piR-50437-336 ZNF136 ILF3 KRI1
GH19J010975 Enhancer 0.8 ENCODE 85.8 -790.4 -790361 3.1 ZNF300 ZNF662 TEAD1 ZEB1 OSR2 ZNF491 ZNF585B SALL2 KLF9 WT1 ZNF441 ZNF627 ILF3 ZNF439 QTRT1 ILF3-DT ENSG00000213304 HNRNPA1P10 ZNF823 ZNF763
GH19J010834 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 29.8 -930.9 -930891 2.6 RXRA ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC TCF12 POLR2G C19orf38 TMED1 ILF3 KRI1 ZNF627 DNMT1 ZNF491 ZNF441 RAVER1 PPAN
GH19J011478 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 36.2 -285.8 -285799 4 HNRNPK ZNF217 EP300 CTCF NRF1 TCF12 MYC POLR2G USF1 SP1 ELAVL3 lnc-ELAVL3-1 ZNF441 ZNF491 TIMM29 ZNF625 ILF3 ENSG00000242615 ZNF844 ZNF433
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF441 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF441

Genomic Locations for ZNF441 Gene

Genomic Locations for ZNF441 Gene
chr19:11,767,000-11,784,078
(GRCh38/hg38)
Size:
17,079 bases
Orientation:
Plus strand
chr19:11,877,815-11,894,893
(GRCh37/hg19)
Size:
17,079 bases
Orientation:
Plus strand

Genomic View for ZNF441 Gene

Genes around ZNF441 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF441 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF441 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF441 Gene

Proteins for ZNF441 Gene

  • Protein details for ZNF441 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Z8-ZN441_HUMAN
    Recommended name:
    Zinc finger protein 441
    Protein Accession:
    Q8N8Z8

    Protein attributes for ZNF441 Gene

    Size:
    693 amino acids
    Molecular mass:
    80136 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04661.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF441 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF441 Gene

Post-translational modifications for ZNF441 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF441 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF441 Gene

Domains & Families for ZNF441 Gene

Gene Families for ZNF441 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF441 Gene

Suggested Antigen Peptide Sequences for ZNF441 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 441 (ZN441_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8Z8

UniProtKB/Swiss-Prot:

ZN441_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF441: view

Function for ZNF441 Gene

Molecular function for ZNF441 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF441 Gene

Gene Ontology (GO) - Molecular Function for ZNF441 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF441: view
genes like me logo Genes that share phenotypes with ZNF441: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF441 Gene

Localization for ZNF441 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF441 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF441 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF441 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF441: view

Pathways & Interactions for ZNF441 Gene

PathCards logo

SuperPathways for ZNF441 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF441: view

Pathways by source for ZNF441 Gene

2 Reactome pathways for ZNF441 Gene

Interacting Proteins for ZNF441 Gene

;

Gene Ontology (GO) - Biological Process for ZNF441 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF441: view

No data available for SIGNOR curated interactions for ZNF441 Gene

Drugs & Compounds for ZNF441 Gene

No Compound Related Data Available

Transcripts for ZNF441 Gene

mRNA/cDNA for ZNF441 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF441 Gene

No ASD Table

Relevant External Links for ZNF441 Gene

GeneLoc Exon Structure for
ZNF441

Expression for ZNF441 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF441 Gene

Protein differential expression in normal tissues from HIPED for ZNF441 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF441 Gene



Protein tissue co-expression partners for ZNF441 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF441

SOURCE GeneReport for Unigene cluster for ZNF441 Gene:

Hs.675132
genes like me logo Genes that share expression patterns with ZNF441: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF441 Gene

Orthologs for ZNF441 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF441 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF441 31 30
  • 99.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 47 (a)
ManyToMany
Species where no ortholog for ZNF441 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF441 Gene

ENSEMBL:
Gene Tree for ZNF441 (if available)
TreeFam:
Gene Tree for ZNF441 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF441: view image

Paralogs for ZNF441 Gene

(496) SIMAP similar genes for ZNF441 Gene using alignment to 2 proteins:

  • ZN441_HUMAN
  • J3KQM6_HUMAN
genes like me logo Genes that share paralogs with ZNF441: view

Variants for ZNF441 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF441 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
709377 Benign: not provided 11,781,738(+) T/A SYNONYMOUS_VARIANT
781457 Benign: not provided 11,777,703(+) G/C SYNONYMOUS_VARIANT
784386 Benign: not provided 11,780,091(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF441 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF441 Gene

Variant ID Type Subtype PubMed ID
esv33306 CNV gain 17666407
nsv525966 CNV gain 19592680

Variation tolerance for ZNF441 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF441 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF441

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF441 Gene

Disorders for ZNF441 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF441 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocervical carcinoma
  • carcinoma of endocervix
endocervical adenocarcinoma
  • endocervical carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF441

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF441: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF441 Gene

Publications for ZNF441 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 54

Products for ZNF441 Gene

Sources for ZNF441 Gene