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Aliases for ZNF440 Gene

Aliases for ZNF440 Gene

  • Zinc Finger Protein 440 2 3 4 5

External Ids for ZNF440 Gene

Previous GeneCards Identifiers for ZNF440 Gene

  • GC19P011770
  • GC19P011786
  • GC19P011658
  • GC19P011925
  • GC19P011499

Summaries for ZNF440 Gene

GeneCards Summary for ZNF440 Gene

ZNF440 (Zinc Finger Protein 440) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF439.

UniProtKB/Swiss-Prot for ZNF440 Gene

Additional gene information for ZNF440 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF440 Gene

Genomics for ZNF440 Gene

GeneHancer (GH) Regulatory Elements for ZNF440 Gene

Promoters and enhancers for ZNF440 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011813 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 609.5 +0.6 617 3.4 SP1 ZFX ZNF148 POLR2A MLLT1 GTF2F1 ZSCAN21 TFE3 SP7 TRIM24 ZNF440 GC19P011816 ZNF44 ZNF564 WDR83OS ZNF791 ZNF700 ZNF799 ZNF136 TRIR
GH19J011797 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 600.4 -15.6 -15583 2.6 SP1 ELF3 CTCF CBFA2T2 NKRF CEBPG AHR PPARG SP5 RAD21 ZNF491 ENSG00000267646 GC19P011801 PIR49375 ZNF440 ZNF441 ZNF625-ZNF20 ZNF439 ZNF433-AS1 RNA5SP464
GH19J011812 Enhancer 0.6 Ensembl 600.7 -2.0 -1983 0.6 CTCF RAD21 ZNF512 GATAD2A REST TRIM22 RUNX3 SAP130 SMC3 PTBP1 ZNF440 ZNF433-AS1 RNA5SP464 ZNF433 ZNF625-ZNF20 ZNF44 ZNF491 PIR49375 GC19P011801
GH19J011343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.5 -468.5 -468538 5 MTA3 CC2D1A SP1 ELF3 CBFA2T2 NKRF ZNF121 CEBPG ZNF687 NFIB CCDC159 PIR44072 RAB3D PIR37751 TMEM205 ILF3 KRI1 ZNF136 ZNF627 ZNF44
GH19J011534 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.7 -278.2 -278151 2.5 CC2D1A SP1 ZFX CTCF ELF3 ZNF148 NKRF CEBPG GTF2F1 ZNF687 CNN1 GC19P011537 ILF3 KRI1 ZNF136 ZNF627 ZNF700 ZNF763 ZNF44 ZNF799
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF440 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF440 Gene

Genomic Locations for ZNF440 Gene
21,334 bases
Plus strand
20,918 bases
Plus strand

Genomic View for ZNF440 Gene

Genes around ZNF440 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF440 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF440 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF440 Gene

Proteins for ZNF440 Gene

  • Protein details for ZNF440 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 440
    Protein Accession:
    Secondary Accessions:
    • Q8N1R9

    Protein attributes for ZNF440 Gene

    595 amino acids
    Molecular mass:
    69106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF440 Gene

Post-translational modifications for ZNF440 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF440 Gene

No data available for DME Specific Peptides for ZNF440 Gene

Domains & Families for ZNF440 Gene

Gene Families for ZNF440 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF440 Gene

Suggested Antigen Peptide Sequences for ZNF440 Gene

GenScript: Design optimal peptide antigens:
  • ZNF440 protein (Q05DD3_HUMAN)
  • Zinc finger protein 440 (ZN440_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF440: view

Function for ZNF440 Gene

Molecular function for ZNF440 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF440 Gene

Gene Ontology (GO) - Molecular Function for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF440: view
genes like me logo Genes that share phenotypes with ZNF440: view

Animal Model Products

CRISPR Products

miRNA for ZNF440 Gene

miRTarBase miRNAs that target ZNF440

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF440

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF440 Gene

Localization for ZNF440 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF440 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF440 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF440: view

Pathways & Interactions for ZNF440 Gene

genes like me logo Genes that share pathways with ZNF440: view

Pathways by source for ZNF440 Gene

2 Reactome pathways for ZNF440 Gene
1 KEGG pathway for ZNF440 Gene

Gene Ontology (GO) - Biological Process for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF440: view

No data available for SIGNOR curated interactions for ZNF440 Gene

Drugs & Compounds for ZNF440 Gene

No Compound Related Data Available

Transcripts for ZNF440 Gene

mRNA/cDNA for ZNF440 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF440 Gene

Zinc finger protein 440:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF440

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF440 Gene

No ASD Table

Relevant External Links for ZNF440 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF440 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF440 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF440 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF440 Gene:


SOURCE GeneReport for Unigene cluster for ZNF440 Gene:

genes like me logo Genes that share expression patterns with ZNF440: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF440 Gene

Orthologs for ZNF440 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF440 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF440 35 34
  • 98.99 (n)
(Bos Taurus)
Mammalia -- 35
  • 46 (a)
Species where no ortholog for ZNF440 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF440 Gene

Gene Tree for ZNF440 (if available)
Gene Tree for ZNF440 (if available)
Evolutionary constrained regions (ECRs) for ZNF440: view image

Paralogs for ZNF440 Gene

(443) SIMAP similar genes for ZNF440 Gene using alignment to 6 proteins:

  • ZN440_HUMAN
  • C9J3D9_HUMAN
  • C9JG89_HUMAN
  • C9JV94_HUMAN
  • K7EJ55_HUMAN
  • Q05DD3_HUMAN
genes like me logo Genes that share paralogs with ZNF440: view

Variants for ZNF440 Gene

Sequence variations from dbSNP and Humsavar for ZNF440 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000153301 -- 11,821,230(+) G/A intron_variant
rs1000821042 -- 11,831,708(+) G/A coding_sequence_variant, missense_variant
rs1000863354 -- 11,820,608(+) GGG/GG intron_variant
rs1000926537 -- 11,816,483(+) G/A intron_variant
rs1000983691 -- 11,815,434(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF440 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv2718185 CNV deletion 23290073
esv3643677 CNV gain 21293372
esv3643678 CNV gain 21293372
nsv458356 CNV gain 19166990
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF440 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF440 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF440 Gene

Disorders for ZNF440 Gene

Additional Disease Information for ZNF440

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF440 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF440 Gene

Publications for ZNF440 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58

Products for ZNF440 Gene

Sources for ZNF440 Gene

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