Aliases for ZNF440 Gene

Aliases for ZNF440 Gene

  • Zinc Finger Protein 440 2 3 4 5

External Ids for ZNF440 Gene

Previous GeneCards Identifiers for ZNF440 Gene

  • GC19P011770
  • GC19P011786
  • GC19P011658
  • GC19P011925
  • GC19P011499

Summaries for ZNF440 Gene

GeneCards Summary for ZNF440 Gene

ZNF440 (Zinc Finger Protein 440) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF439.

UniProtKB/Swiss-Prot Summary for ZNF440 Gene

Additional gene information for ZNF440 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF440 Gene

Genomics for ZNF440 Gene

GeneHancer (GH) Regulatory Elements for ZNF440 Gene

Promoters and enhancers for ZNF440 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF440 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF440

Genomic Locations for ZNF440 Gene

Genomic Locations for ZNF440 Gene
chr19:11,814,273-11,835,617
(GRCh38/hg38)
Size:
21,345 bases
Orientation:
Plus strand
chr19:11,925,099-11,946,016
(GRCh37/hg19)
Size:
20,918 bases
Orientation:
Plus strand

Genomic View for ZNF440 Gene

Genes around ZNF440 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF440 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF440 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF440 Gene

Proteins for ZNF440 Gene

  • Protein details for ZNF440 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYI8-ZN440_HUMAN
    Recommended name:
    Zinc finger protein 440
    Protein Accession:
    Q8IYI8
    Secondary Accessions:
    • Q8N1R9

    Protein attributes for ZNF440 Gene

    Size:
    595 amino acids
    Molecular mass:
    69106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF440 Gene

Post-translational modifications for ZNF440 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF440 Gene

No data available for DME Specific Peptides for ZNF440 Gene

Domains & Families for ZNF440 Gene

Gene Families for ZNF440 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF440 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF440 Gene

GenScript: Design optimal peptide antigens:
  • ZNF440 protein (Q05DD3_HUMAN)
  • Zinc finger protein 440 (ZN440_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYI8

UniProtKB/Swiss-Prot:

ZN440_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF440: view

Function for ZNF440 Gene

Molecular function for ZNF440 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF440 Gene

Gene Ontology (GO) - Molecular Function for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 16189514
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF440: view
genes like me logo Genes that share phenotypes with ZNF440: view

Animal Model Products

CRISPR Products

miRNA for ZNF440 Gene

miRTarBase miRNAs that target ZNF440

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF440

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF440 Gene

Localization for ZNF440 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF440 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF440 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF440: view

Pathways & Interactions for ZNF440 Gene

genes like me logo Genes that share pathways with ZNF440: view

Pathways by source for ZNF440 Gene

2 Reactome pathways for ZNF440 Gene
1 KEGG pathway for ZNF440 Gene

Gene Ontology (GO) - Biological Process for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF440: view

No data available for SIGNOR curated interactions for ZNF440 Gene

Drugs & Compounds for ZNF440 Gene

No Compound Related Data Available

Transcripts for ZNF440 Gene

mRNA/cDNA for ZNF440 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF440

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF440 Gene

No ASD Table

Relevant External Links for ZNF440 Gene

GeneLoc Exon Structure for
ZNF440

Expression for ZNF440 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF440 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF440 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF440

SOURCE GeneReport for Unigene cluster for ZNF440 Gene:

Hs.418192
genes like me logo Genes that share expression patterns with ZNF440: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF440 Gene

Orthologs for ZNF440 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF440 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF440 31 30
  • 98.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 46 (a)
ManyToMany
Species where no ortholog for ZNF440 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF440 Gene

ENSEMBL:
Gene Tree for ZNF440 (if available)
TreeFam:
Gene Tree for ZNF440 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF440: view image

Paralogs for ZNF440 Gene

(443) SIMAP similar genes for ZNF440 Gene using alignment to 6 proteins:

  • ZN440_HUMAN
  • C9J3D9_HUMAN
  • C9JG89_HUMAN
  • C9JV94_HUMAN
  • K7EJ55_HUMAN
  • Q05DD3_HUMAN
genes like me logo Genes that share paralogs with ZNF440: view

Variants for ZNF440 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF440 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769959 Benign: not provided 11,830,406(+) T/A MISSENSE_VARIANT
780069 Likely Benign: not provided 11,832,410(+) C/T NONSENSE
rs400106 - p.Ser569Asn
rs424132 - p.Leu43Ile
rs427880 - p.Asn124Ser

Additional dbSNP identifiers (rs#s) for ZNF440 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF440 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv2718185 CNV deletion 23290073
esv3643677 CNV gain 21293372
esv3643678 CNV gain 21293372
nsv458356 CNV gain 19166990
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF440 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF440 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF440

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF440 Gene

Disorders for ZNF440 Gene

Additional Disease Information for ZNF440

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF440 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF440 Gene

Publications for ZNF440 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 54

Products for ZNF440 Gene

Sources for ZNF440 Gene