Aliases for ZNF44 Gene

Aliases for ZNF44 Gene

  • Zinc Finger Protein 44 2 3 4 5
  • Zinc Finger Protein 58 2 3 4
  • Zinc Finger Protein 55 2 3 4
  • KOX7 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 2 3 4
  • Zinc Finger Protein KOX7 3 4
  • GIOT-2 3 4
  • ZNF504 2 3
  • ZNF55 3 4
  • ZNF58 3 4
  • Gonadotropin Inducible Transcription Repressor-2 3
  • Zinc Finger Protein 44 (KOX 7) 2
  • Zinc Finger Protein ZnFP12 3
  • ZNF44 5
  • GIOT2 4
  • ZNF 3

External Ids for ZNF44 Gene

Previous HGNC Symbols for ZNF44 Gene

  • ZNF58
  • ZNF55

Previous GeneCards Identifiers for ZNF44 Gene

  • GC16U990063
  • GC19M012190
  • GC19M012214
  • GC19M012118
  • GC19M012196
  • GC19M012243
  • GC19M012354
  • GC19M011957
  • GC19M012336

Summaries for ZNF44 Gene

GeneCards Summary for ZNF44 Gene

ZNF44 (Zinc Finger Protein 44) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF823.

UniProtKB/Swiss-Prot Summary for ZNF44 Gene

Gene Wiki entry for ZNF44 Gene

Additional gene information for ZNF44 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF44 Gene

Genomics for ZNF44 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF44 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF44 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF44

Top Transcription factor binding sites by QIAGEN in the ZNF44 gene promoter:
  • AP-4
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Lmo2
  • Pax-5
  • RP58
  • XBP-1

Genomic Locations for ZNF44 Gene

Genomic Locations for ZNF44 Gene
chr19:12,224,686-12,294,899
(GRCh38/hg38)
Size:
70,214 bases
Orientation:
Minus strand
chr19:12,335,501-12,405,714
(GRCh37/hg19)
Size:
70,214 bases
Orientation:
Minus strand

Genomic View for ZNF44 Gene

Genes around ZNF44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF44 Gene

Proteins for ZNF44 Gene

  • Protein details for ZNF44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15621-ZNF44_HUMAN
    Recommended name:
    Zinc finger protein 44
    Protein Accession:
    P15621
    Secondary Accessions:
    • B4DML9
    • B9EGJ5
    • B9ZVM2
    • P17018
    • Q9ULZ7

    Protein attributes for ZNF44 Gene

    Size:
    663 amino acids
    Molecular mass:
    76524 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA34357.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF44 Gene

Post-translational modifications for ZNF44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF44 Gene

Domains & Families for ZNF44 Gene

Gene Families for ZNF44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF44 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF44 Gene

GenScript: Design optimal peptide antigens:
  • DNA-binding protein (Q15927_HUMAN)
  • Zinc finger protein KOX7 (ZNF44_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15621

UniProtKB/Swiss-Prot:

ZNF44_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF44: view

Function for ZNF44 Gene

Molecular function for ZNF44 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 44 (KOX7) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF44 Gene

Gene Ontology (GO) - Molecular Function for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF44: view
genes like me logo Genes that share phenotypes with ZNF44: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF44

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF44 Gene

Localization for ZNF44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF44 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF44 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF44: view

Pathways & Interactions for ZNF44 Gene

PathCards logo

SuperPathways for ZNF44 Gene

genes like me logo Genes that share pathways with ZNF44: view

Pathways by source for ZNF44 Gene

1 KEGG pathway for ZNF44 Gene

Gene Ontology (GO) - Biological Process for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF44: view

No data available for SIGNOR curated interactions for ZNF44 Gene

Drugs & Compounds for ZNF44 Gene

(1) Drugs for ZNF44 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF44: view

Transcripts for ZNF44 Gene

mRNA/cDNA for ZNF44 Gene

7 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF44

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF44 Gene

No ASD Table

Relevant External Links for ZNF44 Gene

GeneLoc Exon Structure for
ZNF44

Expression for ZNF44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF44 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF44

SOURCE GeneReport for Unigene cluster for ZNF44 Gene:

Hs.296731

Evidence on tissue expression from TISSUES for ZNF44 Gene

  • Nervous system(4.9)
  • Lung(3.3)
  • Skin(2.8)
  • Kidney(2.7)
  • Muscle(2.4)
  • Liver(2.3)
  • Blood(2.3)
  • Heart(2.2)
  • Intestine(2.2)
  • Spleen(2.2)
  • Pancreas(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ZNF44: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF44 Gene

Orthologs for ZNF44 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF44 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF44 30 31
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 49 (a)
ManyToMany
Species where no ortholog for ZNF44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF44 Gene

ENSEMBL:
Gene Tree for ZNF44 (if available)
TreeFam:
Gene Tree for ZNF44 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF44: view image

Paralogs for ZNF44 Gene

(497) SIMAP similar genes for ZNF44 Gene using alignment to 5 proteins:

  • ZNF44_HUMAN
  • E2QRP2_HUMAN
  • F8W7T7_HUMAN
  • I6L4V1_HUMAN
  • M0R160_HUMAN

Pseudogenes.org Pseudogenes for ZNF44 Gene

genes like me logo Genes that share paralogs with ZNF44: view

Variants for ZNF44 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF44 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
718725 Benign: not provided 12,272,743(-) A/G SYNONYMOUS_VARIANT
777291 Benign: not provided 12,272,928(-) G/A MISSENSE_VARIANT
787480 Benign: not provided 12,273,454(-) T/C SYNONYMOUS_VARIANT
789241 Likely Benign: not provided 12,273,596(-) G/A MISSENSE_VARIANT
789242 Likely Benign: not provided 12,275,985(-) C/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF44 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF44 Gene

Variant ID Type Subtype PubMed ID
esv2667434 CNV deletion 23128226
esv2718192 CNV deletion 23290073
esv3396662 CNV insertion 20981092
esv3643696 CNV loss 21293372
nsv1064034 CNV gain 25217958
nsv833753 CNV loss 17160897
nsv978773 CNV duplication 23825009

Variation tolerance for ZNF44 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.06; 80.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF44 Gene

Human Gene Mutation Database (HGMD)
ZNF44
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF44

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF44 Gene

Disorders for ZNF44 Gene

No disorders were found for ZNF44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF44 Gene

Publications for ZNF44 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3
  2. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1. (PMID: 29871923) Chen S … Xu G (The Journal of biological chemistry 2018) 3

Products for ZNF44 Gene

Sources for ZNF44 Gene