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Aliases for ZNF44 Gene

Aliases for ZNF44 Gene

  • Zinc Finger Protein 44 2 3 3 5
  • Zinc Finger Protein 55 2 3 4
  • Zinc Finger Protein 58 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 2 3 4
  • Zinc Finger Protein KOX7 3 4
  • GIOT-2 3 4
  • ZNF55 3 4
  • ZNF58 3 4
  • KOX7 3 4
  • Gonadotropin Inducible Transcription Repressor-2 3
  • Zinc Finger Protein 44 (KOX 7) 2
  • Zinc Finger Protein ZnFP12 3
  • ZNF504 3
  • GIOT2 4
  • ZNF 3

External Ids for ZNF44 Gene

Previous HGNC Symbols for ZNF44 Gene

  • ZNF58
  • ZNF55

Previous GeneCards Identifiers for ZNF44 Gene

  • GC16U990063
  • GC19M012190
  • GC19M012214
  • GC19M012118
  • GC19M012196
  • GC19M012243
  • GC19M012354
  • GC19M011957
  • GC19M012336

Summaries for ZNF44 Gene

GeneCards Summary for ZNF44 Gene

ZNF44 (Zinc Finger Protein 44) is a Protein Coding gene. Diseases associated with ZNF44 include Split-Hand/Foot Malformation 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF442.

UniProtKB/Swiss-Prot for ZNF44 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF44 Gene

Additional gene information for ZNF44 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF44 Gene

Genomics for ZNF44 Gene

GeneHancer (GH) Regulatory Elements for ZNF44 Gene

Promoters and enhancers for ZNF44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012293 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 712.3 +0.4 382 2.9 PKNOX1 MLX ARID4B SIN3A YY1 POLR2B ZNF766 CBX5 ZNF143 FOS ZNF44 ZNF136 ZNF20 ZNF700 ZNF763 ZNF564 ZNF878 TRMT1 TRIR ZNF627
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 95 -494.4 -494399 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 IER2 ZNF136 CCDC130 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 ZNF700
GH19J013148 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 85.8 -858.8 -858796 10.2 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX10 ENSG00000267598 IER2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS ZNF791
GH19J012609 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 60.9 -317.5 -317462 4.8 ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 ZNF490 ZNF791 PIR37932 ZNF136 ZNF44 ZNF442 ZNF20 ZNF844 ZNF700 ZNF564
GH19J012936 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 51.9 -644.2 -644233 5.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 CALR MIR6515 ZNF136 TRMT1 CCDC130 ZNF625 ZNF763 ZNF44 ZNF799 RPS6P25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF44 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF44 gene promoter:
  • Pax-5
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • XBP-1
  • AP-4
  • RP58
  • Lmo2

Genomic Locations for ZNF44 Gene

Genomic Locations for ZNF44 Gene
chr19:12,224,686-12,294,899
(GRCh38/hg38)
Size:
70,214 bases
Orientation:
Minus strand
chr19:12,335,501-12,405,714
(GRCh37/hg19)
Size:
70,214 bases
Orientation:
Minus strand

Genomic View for ZNF44 Gene

Genes around ZNF44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF44 Gene

Proteins for ZNF44 Gene

  • Protein details for ZNF44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15621-ZNF44_HUMAN
    Recommended name:
    Zinc finger protein 44
    Protein Accession:
    P15621
    Secondary Accessions:
    • B4DML9
    • B9EGJ5
    • B9ZVM2
    • P17018
    • Q9ULZ7

    Protein attributes for ZNF44 Gene

    Size:
    663 amino acids
    Molecular mass:
    76524 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA34357.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF44 Gene

Post-translational modifications for ZNF44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF44 Gene

Domains & Families for ZNF44 Gene

Gene Families for ZNF44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF44 Gene

Suggested Antigen Peptide Sequences for ZNF44 Gene

Graphical View of Domain Structure for InterPro Entry

P15621

UniProtKB/Swiss-Prot:

ZNF44_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF44: view

Function for ZNF44 Gene

Molecular function for ZNF44 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 44 (KOX7) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF44 Gene

Gene Ontology (GO) - Molecular Function for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF44: view
genes like me logo Genes that share phenotypes with ZNF44: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF44 Gene

Localization for ZNF44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF44 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF44 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF44: view

Pathways & Interactions for ZNF44 Gene

SuperPathways for ZNF44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF44: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF44 Gene

Drugs & Compounds for ZNF44 Gene

(1) Drugs for ZNF44 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF44: view

Transcripts for ZNF44 Gene

Unigene Clusters for ZNF44 Gene

Zinc finger protein 44:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF44 Gene

No ASD Table

Relevant External Links for ZNF44 Gene

GeneLoc Exon Structure for
ZNF44
ECgene alternative splicing isoforms for
ZNF44

Expression for ZNF44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF44 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF44 Gene:

ZNF44

SOURCE GeneReport for Unigene cluster for ZNF44 Gene:

Hs.296731

Evidence on tissue expression from TISSUES for ZNF44 Gene

  • Nervous system(4.8)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with ZNF44: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF44 Gene

Orthologs for ZNF44 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF44 34 33
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
ManyToMany
Species where no ortholog for ZNF44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF44 Gene

ENSEMBL:
Gene Tree for ZNF44 (if available)
TreeFam:
Gene Tree for ZNF44 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF44: view image

Paralogs for ZNF44 Gene

(497) SIMAP similar genes for ZNF44 Gene using alignment to 5 proteins:

  • ZNF44_HUMAN
  • E2QRP2_HUMAN
  • F8W7T7_HUMAN
  • I6L4V1_HUMAN
  • M0R160_HUMAN

Pseudogenes.org Pseudogenes for ZNF44 Gene

genes like me logo Genes that share paralogs with ZNF44: view

Variants for ZNF44 Gene

Sequence variations from dbSNP and Humsavar for ZNF44 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000001927 -- 12,269,818(-) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000043932 -- 12,260,917(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000050051 -- 12,227,951(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000083734 -- 12,289,415(-) CCCC/CCC genic_upstream_transcript_variant, intron_variant
rs1000096087 -- 12,290,465(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF44 Gene

Variant ID Type Subtype PubMed ID
esv2667434 CNV deletion 23128226
esv2718192 CNV deletion 23290073
esv3396662 CNV insertion 20981092
esv3643696 CNV loss 21293372
nsv1064034 CNV gain 25217958
nsv833753 CNV loss 17160897
nsv978773 CNV duplication 23825009

Variation tolerance for ZNF44 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.06; 80.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF44 Gene

Human Gene Mutation Database (HGMD)
ZNF44
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF44

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF44 Gene

Disorders for ZNF44 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF44 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
- elite association - COSMIC cancer census association via MalaCards
Search ZNF44 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF44

genes like me logo Genes that share disorders with ZNF44: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF44 Gene

Publications for ZNF44 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 58
  2. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 58
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. (PMID: 19887448) Frietze S … Farnham PJ (The Journal of biological chemistry 2010) 22 58

Products for ZNF44 Gene