Aliases for ZNF439 Gene

Aliases for ZNF439 Gene

  • Zinc Finger Protein 439 2 3 4 5

External Ids for ZNF439 Gene

Previous GeneCards Identifiers for ZNF439 Gene

  • GC19P011804
  • GC19P011960
  • GC19P011552

Summaries for ZNF439 Gene

GeneCards Summary for ZNF439 Gene

ZNF439 (Zinc Finger Protein 439) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF440.

UniProtKB/Swiss-Prot Summary for ZNF439 Gene

Additional gene information for ZNF439 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF439 Gene

Genomics for ZNF439 Gene

GeneHancer (GH) Regulatory Elements for ZNF439 Gene

Promoters and enhancers for ZNF439 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF439 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF439

Genomic Locations for ZNF439 Gene

Genomic Locations for ZNF439 Gene
chr19:11,848,530-11,883,750
(GRCh38/hg38)
Size:
35,221 bases
Orientation:
Plus strand
chr19:11,959,541-11,994,565
(GRCh37/hg19)
Size:
35,025 bases
Orientation:
Plus strand

Genomic View for ZNF439 Gene

Genes around ZNF439 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF439 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF439 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF439 Gene

Proteins for ZNF439 Gene

  • Protein details for ZNF439 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDP4-ZN439_HUMAN
    Recommended name:
    Zinc finger protein 439
    Protein Accession:
    Q8NDP4
    Secondary Accessions:
    • Q8IYZ7
    • Q96SU1

    Protein attributes for ZNF439 Gene

    Size:
    499 amino acids
    Molecular mass:
    58395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55187.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF439 Gene

Post-translational modifications for ZNF439 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF439 Gene

Domains & Families for ZNF439 Gene

Gene Families for ZNF439 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF439 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF439 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 439 (ZN439_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NDP4

UniProtKB/Swiss-Prot:

ZN439_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF439: view

Function for ZNF439 Gene

Molecular function for ZNF439 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF439 Gene

Gene Ontology (GO) - Molecular Function for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 16189514
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF439: view
genes like me logo Genes that share phenotypes with ZNF439: view

miRNA for ZNF439 Gene

miRTarBase miRNAs that target ZNF439

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF439 Gene

Localization for ZNF439 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF439 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF439 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF439: view

Pathways & Interactions for ZNF439 Gene

genes like me logo Genes that share pathways with ZNF439: view

Pathways by source for ZNF439 Gene

2 Reactome pathways for ZNF439 Gene
1 KEGG pathway for ZNF439 Gene

Gene Ontology (GO) - Biological Process for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF439: view

No data available for SIGNOR curated interactions for ZNF439 Gene

Drugs & Compounds for ZNF439 Gene

No Compound Related Data Available

Transcripts for ZNF439 Gene

mRNA/cDNA for ZNF439 Gene

9 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF439 Gene

No ASD Table

Relevant External Links for ZNF439 Gene

GeneLoc Exon Structure for
ZNF439

Expression for ZNF439 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF439 Gene

Protein differential expression in normal tissues from HIPED for ZNF439 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF439 Gene



Protein tissue co-expression partners for ZNF439 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF439

SOURCE GeneReport for Unigene cluster for ZNF439 Gene:

Hs.528731

Evidence on tissue expression from TISSUES for ZNF439 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF439: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF439 Gene

Orthologs for ZNF439 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF439 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF439 31 30
  • 93.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 33
Species where no ortholog for ZNF439 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF439 Gene

ENSEMBL:
Gene Tree for ZNF439 (if available)
TreeFam:
Gene Tree for ZNF439 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF439: view image

Paralogs for ZNF439 Gene

(447) SIMAP similar genes for ZNF439 Gene using alignment to 2 proteins:

  • ZN439_HUMAN
  • C9JMA7_HUMAN
genes like me logo Genes that share paralogs with ZNF439: view

Variants for ZNF439 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF439 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10421552 - p.Pro6Ser
rs10500209 - p.Leu427Ser

Additional dbSNP identifiers (rs#s) for ZNF439 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF439 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv2718185 CNV deletion 23290073
esv3643677 CNV gain 21293372
nsv458356 CNV gain 19166990
nsv482214 CNV gain 20164927
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF439 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF439 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF439

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF439 Gene

Disorders for ZNF439 Gene

Additional Disease Information for ZNF439

No disorders were found for ZNF439 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF439 Gene

Publications for ZNF439 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for ZNF439 Gene

Sources for ZNF439 Gene