Aliases for ZNF438 Gene

Aliases for ZNF438 Gene

  • Zinc Finger Protein 438 2 3 4 5
  • BA330O11.1 3

External Ids for ZNF438 Gene

Previous GeneCards Identifiers for ZNF438 Gene

  • GC10M031174
  • GC10M030852
  • GC10M031133
  • GC10M031111

Summaries for ZNF438 Gene

GeneCards Summary for ZNF438 Gene

ZNF438 (Zinc Finger Protein 438) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot Summary for ZNF438 Gene

Additional gene information for ZNF438 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF438 Gene

Genomics for ZNF438 Gene

GeneHancer (GH) Regulatory Elements for ZNF438 Gene

Promoters and enhancers for ZNF438 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J031030 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 757 -0.3 -290 5.2 CTCF POLR2A USF2 ATF1 CREB1 HCFC1 ZNF362 MYC ETV6 L3MBTL2 ZNF438 ENSG00000287564 LOC105376481 lnc-ZEB1-11 LINC02664 DDX10P1 MTPAP
GH10J030955 Promoter 0.3 EPDnew 750.2 +76.8 76774 0.1 ZNF438 piR-37026-051 piR-57133-052
GH10J030995 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 43.4 +34.3 34306 6.2 MYC MAX ZFX SP1 MLLT1 PRDM1 TRIM24 IKZF1 ZNF143 ATF7 ZNF438 ENSG00000259994 LINC02664 DDX10P1 piR-57133-052
GH10J031132 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 18 -103.1 -103109 5.8 SMARCE1 L3MBTL2 MAX TEAD4 ZNF148 POLR2A ZFX CBFA2T2 MLLT1 ZNF687 LOC105376482 LOC105376483 HSALNG0077081 lnc-ZEB1-2 ZNF438 LINC02664 DDX10P1 HSALNG0077080 ENSG00000287564 lnc-ZEB1-11
GH10J031003 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 27.3 +27.7 27677 2.1 ETV6 ZNF148 MAFK BACH1 IKZF1 IKZF2 NFE2L2 ZNF316 NFE2 DPF2 ZNF438 DDX10P1 piR-57133-052
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF438 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF438 gene promoter:
  • aMEF-2
  • E2F
  • E2F-1
  • Egr-1
  • FOXO4
  • Lhx3a
  • LHX3b
  • MEF-2A
  • POU6F1 (c2)
  • S8

Genomic Locations for ZNF438 Gene

Genomic Locations for ZNF438 Gene
chr10:30,820,207-31,032,407
(GRCh38/hg38)
Size:
212,201 bases
Orientation:
Minus strand
chr10:31,109,136-31,320,866
(GRCh37/hg19)
Size:
211,731 bases
Orientation:
Minus strand

Genomic View for ZNF438 Gene

Genes around ZNF438 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF438 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF438 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF438 Gene

Proteins for ZNF438 Gene

  • Protein details for ZNF438 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4V0-ZN438_HUMAN
    Recommended name:
    Zinc finger protein 438
    Protein Accession:
    Q7Z4V0
    Secondary Accessions:
    • A2A3J4
    • A8K9L5
    • Q5T426
    • Q658Q4
    • Q6ZN65

    Protein attributes for ZNF438 Gene

    Size:
    828 amino acids
    Molecular mass:
    91836 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF438 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF438 Gene

Post-translational modifications for ZNF438 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF438 Gene

Domains & Families for ZNF438 Gene

Gene Families for ZNF438 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF438 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF438 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57968, highly similar to Zinc finger protein 438 (B4DFT8_HUMAN)
  • Zinc finger protein 438, isoform CRA_b (Q5T427_HUMAN)
  • Zinc finger protein 438 (ZN438_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4V0

UniProtKB/Swiss-Prot:

ZN438_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF438: view

Function for ZNF438 Gene

Molecular function for ZNF438 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 acts as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF438 Gene

Gene Ontology (GO) - Molecular Function for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF438: view

Phenotypes for ZNF438 Gene

genes like me logo Genes that share phenotypes with ZNF438: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF438 Gene

Localization for ZNF438 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF438 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF438 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 17669267
GO:0005654 nucleoplasm IDA,IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF438: view

Pathways & Interactions for ZNF438 Gene

PathCards logo

SuperPathways for ZNF438 Gene

No Data Available

Interacting Proteins for ZNF438 Gene

Gene Ontology (GO) - Biological Process for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
GO:0045893 positive regulation of transcription, DNA-templated IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF438: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF438 Gene

Drugs & Compounds for ZNF438 Gene

No Compound Related Data Available

Transcripts for ZNF438 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF438 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for ZNF438 Gene

GeneLoc Exon Structure for
ZNF438
ECgene alternative splicing isoforms for
ZNF438

Expression for ZNF438 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF438 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF438 Gene

This gene is overexpressed in Whole Blood (x7.8).

Protein differential expression in normal tissues from HIPED for ZNF438 Gene

This gene is overexpressed in Plasma (32.3), Peripheral blood mononuclear cells (10.8), Testis (8.4), and CD4 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF438 Gene



Protein tissue co-expression partners for ZNF438 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF438 Gene:

ZNF438

SOURCE GeneReport for Unigene cluster for ZNF438 Gene:

Hs.660642

mRNA Expression by UniProt/SwissProt for ZNF438 Gene:

Q7Z4V0-ZN438_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF438 Gene

  • Heart(4.2)
  • Kidney(4.2)
  • Lung(4.2)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with ZNF438: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF438 Gene

Orthologs for ZNF438 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF438 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF438 33 32
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF438 33 32
  • 76.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp438 32
  • 74.92 (n)
mouse
(Mus musculus)
Mammalia Zfp438 17 33 32
  • 74.61 (n)
cow
(Bos Taurus)
Mammalia ZNF438 33 32
  • 69.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF438 33
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF438 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF438 33 32
  • 57.76 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf438 32
  • 51.81 (n)
zebrafish
(Danio rerio)
Actinopterygii znf438 33 32
  • 49.71 (n)
OneToOne
Species where no ortholog for ZNF438 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF438 Gene

ENSEMBL:
Gene Tree for ZNF438 (if available)
TreeFam:
Gene Tree for ZNF438 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF438: view image

Paralogs for ZNF438 Gene

Paralogs for ZNF438 Gene

(2) SIMAP similar genes for ZNF438 Gene using alignment to 4 proteins:

  • ZN438_HUMAN
  • L8EAU2_HUMAN
  • Q5T427_HUMAN
  • V9GYJ1_HUMAN
genes like me logo Genes that share paralogs with ZNF438: view

Variants for ZNF438 Gene

Sequence variations from dbSNP and Humsavar for ZNF438 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
VAR_035580 A breast cancer sample p.Lys381Asn
rs1000016380 -- 30,957,567(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000027223 -- 30,913,939(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000029425 -- 30,935,713(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000058684 -- 31,001,425(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF438 Gene

Variant ID Type Subtype PubMed ID
dgv1023n54 CNV loss 21841781
dgv1024n54 CNV loss 21841781
dgv1025n54 CNV loss 21841781
dgv1026n54 CNV loss 21841781
dgv126e199 CNV deletion 23128226
dgv200e212 CNV loss 25503493
dgv23n17 CNV loss 16327808
dgv388n106 CNV deletion 24896259
esv21784 CNV gain 19812545
esv2325923 CNV deletion 18987734
esv2421350 CNV deletion 20811451
esv2556462 CNV deletion 19546169
esv2669719 CNV deletion 23128226
esv2762851 CNV loss 21179565
esv2764080 CNV loss 21179565
esv3546109 CNV deletion 23714750
esv3622798 CNV loss 21293372
esv3622800 CNV loss 21293372
nsv1036810 CNV loss 25217958
nsv1043196 CNV gain 25217958
nsv1053490 CNV gain 25217958
nsv1069037 CNV deletion 25765185
nsv1122502 CNV deletion 24896259
nsv1148191 CNV deletion 26484159
nsv1161936 CNV duplication 26073780
nsv474301 CNV novel sequence insertion 20440878
nsv498724 CNV loss 21111241
nsv508575 CNV deletion 20534489
nsv510215 OTHER sequence alteration 20534489
nsv514551 CNV loss 21397061
nsv550327 CNV gain 21841781
nsv550331 CNV loss 21841781
nsv550357 CNV loss 21841781
nsv6243 CNV deletion 18451855
nsv819044 CNV gain 19587683
nsv819898 CNV loss 19587683
nsv821086 CNV deletion 20802225
nsv825333 CNV loss 20364138
nsv831823 CNV gain 17160897
nsv951533 CNV duplication 24416366

Variation tolerance for ZNF438 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF438 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF438

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF438 Gene

Disorders for ZNF438 Gene

Additional Disease Information for ZNF438

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF438 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF438 Gene

Publications for ZNF438 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  2. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity. (PMID: 17669267) Zhong Z … Yu L (Journal of biochemistry and molecular biology 2007) 3 4 56
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 43 56
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for ZNF438 Gene

Sources for ZNF438 Gene