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Aliases for ZNF436 Gene

Aliases for ZNF436 Gene

  • Zinc Finger Protein 436 2 3 5
  • DNA-Binding Protein 3
  • KIAA1710 4
  • Zfp46 3
  • ZNF 3

External Ids for ZNF436 Gene

Previous GeneCards Identifiers for ZNF436 Gene

  • GC01M022746
  • GC01M023155
  • GC01M023431
  • GC01M023558
  • GC01M023685
  • GC01M021937

Summaries for ZNF436 Gene

GeneCards Summary for ZNF436 Gene

ZNF436 (Zinc Finger Protein 436) is a Protein Coding gene. Diseases associated with ZNF436 include Split-Hand/Foot Malformation 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZSCAN2.

UniProtKB/Swiss-Prot for ZNF436 Gene

  • May be a transcriptional repressor.

Gene Wiki entry for ZNF436 Gene

Additional gene information for ZNF436 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF436 Gene

Genomics for ZNF436 Gene

GeneHancer (GH) Regulatory Elements for ZNF436 Gene

Promoters and enhancers for ZNF436 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023366 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 588.2 +0.4 394 6.6 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 ZNF436 ZNF436-AS1 GC01P023371 ENSG00000201405 KDM1A SRSF10 LINC01355 ELOA ZBTB40 RPL11
GH01I023339 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.5 +26.9 26861 6.3 HDGF PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B HNRNPR ZNF436-AS1 ZNF436 ZBTB40 KDM1A ENSG00000201405 SRSF10 ELOA ZBTB40-IT1 TCEA3
GH01I023521 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 -158.8 -158820 13.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 GC01P023526 E2F2 SRSF10 LINC01355 ASAP3 ID3 ZNF436 KDM1A ELOA TCEA3
GH01I023380 Enhancer 0.8 ENCODE dbSUPER 30.4 -11.7 -11701 1.1 BHLHE40 CBFA2T3 ZNF148 ZNF664 ZNF316 IKZF1 CBFA2T2 ZNF600 EMSY SPI1 ZNF436 ENSG00000271420 GC01M023400 TCEA3
GH01I023420 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.8 -53.3 -53334 5.1 HDGF ATF1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 POLR2B PAF1 TCEA3 ASAP3 ZNF436-AS1 ZNF436 ENSG00000201405 LINC01355 ENSG00000232482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF436 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF436 gene promoter:

Genomic Locations for ZNF436 Gene

Genomic Locations for ZNF436 Gene
10,417 bases
Minus strand

Genomic View for ZNF436 Gene

Genes around ZNF436 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF436 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF436 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF436 Gene

Proteins for ZNF436 Gene

  • Protein details for ZNF436 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 436
    Protein Accession:
    Secondary Accessions:
    • Q658I9

    Protein attributes for ZNF436 Gene

    470 amino acids
    Molecular mass:
    54277 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21801.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF436 Gene

Post-translational modifications for ZNF436 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF436 Gene

No data available for DME Specific Peptides for ZNF436 Gene

Domains & Families for ZNF436 Gene

Gene Families for ZNF436 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF436 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF436: view

Function for ZNF436 Gene

Molecular function for ZNF436 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF436 Gene

Gene Ontology (GO) - Molecular Function for ZNF436 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 23455924
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF436: view
genes like me logo Genes that share phenotypes with ZNF436: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF436 Gene

Localization for ZNF436 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF436 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF436 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF436 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF436: view

Pathways & Interactions for ZNF436 Gene

SuperPathways for ZNF436 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF436: view

Pathways by source for ZNF436 Gene

2 Reactome pathways for ZNF436 Gene

Gene Ontology (GO) - Biological Process for ZNF436 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF436: view

No data available for SIGNOR curated interactions for ZNF436 Gene

Drugs & Compounds for ZNF436 Gene

No Compound Related Data Available

Transcripts for ZNF436 Gene

mRNA/cDNA for ZNF436 Gene

Unigene Clusters for ZNF436 Gene

Zinc finger protein 436:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF436 Gene

No ASD Table

Relevant External Links for ZNF436 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF436 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF436 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF436 Gene

This gene is overexpressed in Heart (46.1) and Stomach (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF436 Gene

Protein tissue co-expression partners for ZNF436 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF436 Gene:


SOURCE GeneReport for Unigene cluster for ZNF436 Gene:


mRNA Expression by UniProt/SwissProt for ZNF436 Gene:

Tissue specificity: Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.

Evidence on tissue expression from TISSUES for ZNF436 Gene

  • Nervous system(4.6)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with ZNF436: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF436 Gene

Orthologs for ZNF436 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF436 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF436 33 34
  • 99.36 (n)
(Bos Taurus)
Mammalia ZNF436 33 34
  • 92.41 (n)
(Canis familiaris)
Mammalia ZNF436 33 34
  • 92.2 (n)
(Rattus norvegicus)
Mammalia Zfp46 33
  • 84.95 (n)
(Mus musculus)
Mammalia Zfp46 33 16 34
  • 82.3 (n)
(Monodelphis domestica)
Mammalia ZNF436 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
(Gallus gallus)
Aves -- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 44 (a)
ZNF302 34
  • 44 (a)
-- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 38 (a)
-- 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
Species where no ortholog for ZNF436 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF436 Gene

Gene Tree for ZNF436 (if available)
Gene Tree for ZNF436 (if available)

Paralogs for ZNF436 Gene

Paralogs for ZNF436 Gene

(494) SIMAP similar genes for ZNF436 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF436: view

Variants for ZNF436 Gene

Sequence variations from dbSNP and Humsavar for ZNF436 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035579 A breast cancer sample p.Cys196Gly
rs1000373698 -- 23,362,143(-) T/C coding_sequence_variant, synonymous_variant
rs1000489867 -- 23,361,763(-) A/G 3_prime_UTR_variant
rs1000557919 -- 23,368,497(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000669000 -- 23,360,327(-) T/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF436 Gene

Variant ID Type Subtype PubMed ID
nsv525446 CNV gain 19592680

Variation tolerance for ZNF436 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF436 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF436 Gene

Disorders for ZNF436 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF436 Gene - From: DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF436

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF436: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF436 Gene

Publications for ZNF436 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE. (PMID: 17089209) Li Y … Wu X (Molecular biology reports 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF436 Gene

Sources for ZNF436 Gene

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